Patents by Inventor Shu-Hua Jan

Shu-Hua Jan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biodegradable hyaluronic acid derivative
    Patent number: 8425931
    Abstract: The description provides a biodegradable hyaluronic acid derivative including at least one modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C?O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group, and p is an integer of 1 to 4.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: April 23, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Jui-Hsiang Chen, Bin-Hong Tsai, Hsuen-Tseng Chang, Muh-Lan Chen, Yu-Hua Chen, Shu-Hua Jan, Mei-Jung Liu
  • Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
    Patent number: 8313765
    Abstract: The invention provides a biodegradable hyaluronic acid derivative including at least one modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C?O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group, and p is an integer of 1 to 4.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: November 20, 2012
    Assignee: Industrial Technology Research Institute
    Inventors: Jui-Hsiang Chen, Bin-Hong Tsai, Hsuen-Tseng Chang, Muh-Lan Chen, Yu-Hua Chen, Shu-Hua Jan, Mei-Jung Liu
  • Biodegradable Hyaluronic Acid Derivative
    Publication number: 20120283429
    Abstract: The description provides a biodegradable hyaluronic acid derivative including at least one modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C?O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group, and p is an integer of 1 to 4.
    Type: Application
    Filed: July 13, 2012
    Publication date: November 8, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jui-Hsiang Chen, Bin-Hong Tsai, Hsuen-Tseng Chang, Muh-Lan Chen, Yu-Hua Chen, Shu-Hua Jan, Mei-Jung Liu
  • Biodegradable Hyaluronic Acid Derivative, Biodegradable Polymeric Micelle Composition and Pharmaceutical or Bioactive Composition
    Publication number: 20100316682
    Abstract: The invention provides a biodegradable hyaluronic acid derivative including at least one modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C?O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group, and p is an integer of 1 to 4.
    Type: Application
    Filed: August 20, 2010
    Publication date: December 16, 2010
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jui-Hsiang Chen, Bin-Hong Tsai, Hsuen-Tseng Chang, Muh-Lan Chen, Yu-Hua Chen, Shu-Hua Jan, Mei-Jung Liu
  • Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition
    Patent number: 7780982
    Abstract: A biodegradable hyaluronic acid derivative comprising a modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C?O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group or a prepolymer, and p is an integer of 1 to 4. The biodegradable hyaluronic acid derivative when dissolved in a hydrophilic medium can form micelles and can be used to entrap a pharmaceutically active or bioactive molecule.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: August 24, 2010
    Assignee: Industrial Technology Research Instittute
    Inventors: Jui-Hsiang Chen, Bin-Hong Tsai, Hsuen-Tseng Chang, Muh-Lan Chen, Yu-Hua Chen, Shu-Hua Jan, Mei-Jung Liu
  • Method for producing double-crosslinked hyaluronate material
    Publication number: 20070066816
    Abstract: Disclosed is a method for producing a double-crosslinked hyaluronate material. A hyaluronic acid or a salt thereof is sequentially reacted with an epoxide compound and a carbodiimide compound to produce a more biodegradation-resistant hyaluronate material. The HA acid is preferably reacted with the carbodiimide first, and more preferably in a mixed solvent including water and an organic solvent, such as ketone.
    Type: Application
    Filed: September 13, 2006
    Publication date: March 22, 2007
    Applicant: Industrial Technology Research Institute
    Inventors: Shiao-Wen Tsai, Chiung-Lin Yang, Jui-Hsiang Chen, Pei-ching Chang, Li-Ting Su, Shu-Hua Jan
  • Thermosensitive biodegradable copolymer
    Patent number: 7179867
    Abstract: A thermo-sensitve copolymer of following formula; is disclosed; wherein R1 is hydrogen, or —C(?O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection. The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: February 20, 2007
    Assignee: Industrial Technology Research Institute
    Inventors: Ken-Yuan Chang, Ming-Hsi Yeh, Ming-Fa Hsieh, Pei Kan, Yu-Yan Jan, Shu-Hua Jan, Xi-Zhang Lin
  • Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition
    Publication number: 20050123505
    Abstract: A biodegradable hyaluronic acid derivative comprising a modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C?O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group or a prepolymer, and p is an integer of 1 to 4. The biodegradable hyaluronic acid derivative when dissolved in a hydrophilic medium can form micelles and can be used to entrap a pharmaceutically active or bioactive molecule.
    Type: Application
    Filed: November 18, 2004
    Publication date: June 9, 2005
    Inventors: Jui-Hsiang Chen, Bin-Hong Tsai, Hsuen-Tseng Chang, Muh-Lan Chen, Yu-Hua Chen, Shu-Hua Jan, Mei-Jung Liu
  • Thermosensitive biodegradable copolymer
    Publication number: 20050113531
    Abstract: A thermo-sensitve copolymer of following formula; is disclosed; wherein R1 is hydrogen, or —C(?O)—R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection. The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.
    Type: Application
    Filed: November 26, 2003
    Publication date: May 26, 2005
    Applicant: Industrial Technology Research Institute
    Inventors: Ken-Yuan Chang, Ming-Hsi Yeh, Ming-Fa Hsieh, Pei Kan, Yu-Yan Jan, Shu-Hua Jan, Xi-Zhang Lin
  • Method for producing double-crosslinked hyaluronate material
    Publication number: 20040127698
    Abstract: A method for producing a double-crosslinked hyaluronate material. A hyaluronic acid or a salt thereof is sequentially reacted with an epoxide compound and a carbodiimide compound to produce a more biodegradation-resistant hyaluronate material.
    Type: Application
    Filed: December 24, 2003
    Publication date: July 1, 2004
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Shiao-Wen Tsai, Chiung-Lin Yang, Jui-Hsiang Chen, Pei-Ching Chang, Li-Ting Su, Shu-Hua Jan