Patents by Inventor Shu-Hua Lee
Shu-Hua Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11990381Abstract: In an embodiment, a device includes: a package component including: integrated circuit dies; an encapsulant around the integrated circuit dies; a redistribution structure over the encapsulant and the integrated circuit dies, the redistribution structure being electrically coupled to the integrated circuit dies; sockets over the redistribution structure, the sockets being electrically coupled to the redistribution structure; and a support ring over the redistribution structure and surrounding the sockets, the support ring being disposed along outermost edges of the redistribution structure, the support ring at least partially laterally overlapping the redistribution structure.Type: GrantFiled: November 14, 2022Date of Patent: May 21, 2024Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.Inventors: Shu-Rong Chun, Kuo Lung Pan, Tin-Hao Kuo, Hao-Yi Tsai, Pei-Hsuan Lee, Chien Ling Hwang, Yu-Chia Lai, Po-Yuan Teng, Chen-Hua Yu
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Patent number: 11967582Abstract: A multi-chip device includes a first material within a substrate. The first material has a first coefficient of thermal expansion different than a second coefficient of thermal expansion of the substrate. A first chip overlies a first portion of the first material and a first portion of the substrate. A second chip overlies a second portion of the first material and a second portion of the substrate. The first material is between the first portion of the substrate and the second portion of the substrate.Type: GrantFiled: April 24, 2023Date of Patent: April 23, 2024Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LIMITEDInventors: Chin-Hua Wang, Po-Chen Lai, Shu-Shen Yeh, Tsung-Yen Lee, Po-Yao Lin, Shin-Puu Jeng
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Publication number: 20240120294Abstract: A chip package includes a substrate, a semiconductor chip, and a thermal conductive structure. The chip package includes a first and a second support structures below the thermal conductive structure. The first and the second support structures connect the substrate and corners of the thermal conductive structure. The thermal conductive structure has a side edge connecting the first and the second support structures. The first and the second support structures and the side edge together define of an opening exposing a space surrounding the semiconductor chip. The first and the second support structures are disposed along a side of the substrate. The first support structure is laterally separated from the side of the substrate by a first lateral distance. The side edge of the thermal conductive structure is laterally separated from the side of the substrate by a second lateral distance different than the first lateral distance.Type: ApplicationFiled: December 21, 2023Publication date: April 11, 2024Inventors: Shu-Shen YEH, Chin-Hua WANG, Kuang-Chun LEE, Po-Yao LIN, Shyue-Ter LEU, Shin-Puu JENG
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Publication number: 20220056149Abstract: The disclosure relates to fusion proteins, methods of making fusion proteins, and methods of using fusion proteins, wherein the fusion proteins comprise a functional single-domain antibody (sdAb) or a functional variant thereof and a cytosine deaminase (CD) protein or a functional variant thereof, optionally connected via a peptide linker. The fusion proteins of the disclosure also have CD activity. The disclosure also relates to pharmaceutical compositions or formulations comprising such fusion proteins and pharmaceutically acceptable excipients, as well as medical uses of these fusion proteins.Type: ApplicationFiled: September 3, 2021Publication date: February 24, 2022Applicants: LUMOSA THERAPEUTICS, CO., LTD., SHANGHAI LUMOSA THERAPEUTICS, CO., LTD.Inventors: Pei-Jiun CHEN, Shu-Hua LEE
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Publication number: 20190202931Abstract: The disclosure relates to fusion proteins, methods of making fusion proteins, and methods of using fusion proteins, wherein the fusion proteins comprise a functional single-domain antibody (sdAb) or a functional variant thereof and a cytosine deaminase (CD) protein or a functional variant thereof, optionally connected via a peptide linker. The fusion proteins of the disclosure also have CD activity. The disclosure also relates to pharmaceutical compositions or formulations comprising such fusion proteins and pharmaceutically acceptable excipients, as well as medical uses of these fusion proteins.Type: ApplicationFiled: January 4, 2019Publication date: July 4, 2019Applicants: LUMOSA THERAPEUTICS, CO., LTD., SHANGHAI LUMOSA THERAPEUTICS, CO., LTD.Inventors: Pei-Jiun CHEN, Shu-Hua LEE
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Publication number: 20180238895Abstract: The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Lea structure, a Lea-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.Type: ApplicationFiled: January 12, 2018Publication date: August 23, 2018Inventors: Rong-Hwa LIN, Leewen LIN, Shih-Yao LIN, Shu-Hua LEE
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Patent number: 9950077Abstract: The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.Type: GrantFiled: June 19, 2015Date of Patent: April 24, 2018Assignees: BIOALLIANCE C.V., ABGENOMICS INTERNATIONAL INC.Inventors: Rong-Hwa Lin, Shih-Yao Lin, Yu-Chi Hsieh, Chiu-Chen Huang, Shu-Hua Lee, Yu-Ying Tsai, Feng-Lin Chiang, Li-An Hu
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Publication number: 20160139131Abstract: The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Lea structure, a Lea-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.Type: ApplicationFiled: October 20, 2015Publication date: May 19, 2016Inventors: Rong-Hwa LIN, Leewen LIN, Shih-Yao LIN, Shu-Hua LEE
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Publication number: 20160051695Abstract: The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleaved under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker. In some aspects of the present disclosure, the targeting moiety is an anti-HER2 antibody. The present disclosure further provides compositions and methods for treating cancers.Type: ApplicationFiled: June 18, 2015Publication date: February 25, 2016Inventors: Rong-Hwa Lin, Shih-Yao Lin, Yu-Chi Hsieh, Chiu-Chen Huang, Shu-Hua Lee, Yu-Ying Tsai
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Publication number: 20160015827Abstract: The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.Type: ApplicationFiled: June 19, 2015Publication date: January 21, 2016Inventors: Rong-Hwa LIN, Shih-Yao LIN, Yu-Chi HSIEH, Chiu-Chen HUANG, Shu-Hua LEE, Yu-Ying TSAI, Feng-Lin CHIANG, Li-An HU
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Publication number: 20160015831Abstract: The present disclosure provides anti-CD22 antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.Type: ApplicationFiled: June 19, 2015Publication date: January 21, 2016Inventors: Rong-Hwa LIN, Shih-Yao LIN, Yu-Chi HSIEH, Chiu-Chen HUANG, Shu-Hua LEE, Yu-Ying TSAI, Yu-Chin LIN
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Patent number: 9193794Abstract: The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Lea structure, a Lea-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.Type: GrantFiled: January 20, 2010Date of Patent: November 24, 2015Assignee: BioAlliance C.V.Inventors: Rong-Hwa Lin, Leewen Lin, Shih-Yao Lin, Shu-Hua Lee
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Publication number: 20150329783Abstract: A method of manufacturing a microencapsulated phase-change material-containing gypsum plate capable of flame retardation and temperature variation attenuation is introduced, such that an organic microencapsulated phase-change material is uniformly distributed in an inorganic gypsum plate. The method involves putting a microencapsulated phase-change material in a dispersing agent solution, blending the dispersing agent solution to form a first solution, putting the foaming agent in the first solution, putting gypsum powder and starch in the first solution, blending the first solution to form a microencapsulated phase-change material gypsum mixture solution, molding the microencapsulated phase-change material gypsum mixture solution to finalize the manufacturing of a microencapsulated phase-change material-containing gypsum plate capable of flame retardation and temperature variation attenuation.Type: ApplicationFiled: May 16, 2014Publication date: November 19, 2015Applicant: NATIONAL CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: PING-SZU TSAI, YI-HSIUAN YU, JENG-PEI HSIEH, SHU-HUA LEE, HOU-AN HSIEH
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Publication number: 20110165161Abstract: The present invention provides antibodies (such as chimeric and humanized antibodies) specifically bind to epithelial cell adhesion/activating molecule EpCAM expressed on cancer cells and induce cancer cell apoptosis. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.Type: ApplicationFiled: December 23, 2010Publication date: July 7, 2011Inventors: Shih-Yao LIN, Leewen Lin, Feng-Lin Chiang, Shu-Hua Lee, Yu-Ying Tsai
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Publication number: 20100124551Abstract: The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Lea structure, a Lea-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.Type: ApplicationFiled: January 20, 2010Publication date: May 20, 2010Inventors: Rong-Hwa LIN, Leewen Lin, Shih-Yao Lin, Shu-Hua Lee
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Patent number: 7674605Abstract: The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Lea structure, a Lea-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.Type: GrantFiled: June 7, 2007Date of Patent: March 9, 2010Assignee: BioAlliance C.V.Inventors: Rong-Hwa Lin, Leewen Lin, Shih-Yao Lin, Shu-Hua Lee
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Publication number: 20090124688Abstract: A method of inhibiting 15-keto prostaglandin-?13-reductase 2 by contacting 15-keto prostaglandin-?13-reductase 2 with an aryl compound of Formula (I), (II), (III), or (IV) shown herein. Also disclosed are methods of treating peroxisome proliferators-activated receptor related diseases and lowering blood glucose levels by administering to a subject in need thereof an effective amount of such an aryl compound.Type: ApplicationFiled: January 8, 2007Publication date: May 14, 2009Inventors: Rong-Hwa Lin, Leewen Lin, Shih-Yao Lin, Shu-Hua Lee
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Patent number: 7527958Abstract: A truncated 1,3-1,4-?-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.Type: GrantFiled: February 6, 2004Date of Patent: May 5, 2009Assignee: Academia SinicaInventors: Lie-Fen Shyur, Tuan-Nan Wen, Shu-Hua Lee, Ning-Sun Yang
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Publication number: 20080171043Abstract: The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Lea structure, a Lea-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.Type: ApplicationFiled: June 7, 2007Publication date: July 17, 2008Inventors: Rong-Hwa Lin, Leewen Lin, Shih-Yao Lin, Shu-Hua Lee
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Publication number: 20050009164Abstract: A truncated 1,3-1,4-?-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.Type: ApplicationFiled: February 6, 2004Publication date: January 13, 2005Inventors: Lie-Fen Shyur, Tuan-Nan Wen, Shu-Hua Lee, Ning-Sun Yang