Abstract: The invention relates to a method of detecting and/or characterising an immunosuppressive neutrophil comprising determining and/or measuring the expression of one or more anti-apoptotic markers in a neutrophil population. In an embodiment, the immunosuppressive neutrophil is a polymorphonuclear myeloid-derived suppressor cell (PMNMDSC) and the anti-apoptotic marker is TNF-related apoptosis-inducing ligand (TRAIL)-receptor 3 (TRAILR3/TNFRSF10C) and/or decoy TNF-related apoptosis-inducing ligand (TRAIL)-receptor (dcTRAILR1). Also disclosed are methods of evaluating the progression of a proliferative disease in a subject, methods of evaluating the efficacy of a treatment regimen for a proliferative disease in a subject, methods of treating a proliferative disease in a subject, and kits thereof.

Abstract: A semiconductor die included in a semiconductor die package may include a plurality of decoupling trench capacitor regions in a device region of the semiconductor die. At least two or more of the decoupling trench capacitor regions include decoupling trench capacitor structures having different depths. The depths of the decoupling trench capacitor structures in the decoupling trench capacitor regions may be selected to provide sufficient capacitance so as to satisfy circuit decoupling parameters for circuits of the semiconductor die package, while reducing the likelihood of warping, breaking, and/or cracking of the semiconductor die package.

Abstract: The present disclosure discloses a movable box and a method for controlling the same, and a package storage device. The movable box includes a box body, a box door, a security lock and a verification component. The security lock is connected between the box body and the box door, the verification component is disposed on a surface of the box door and is connected to the security lock, and the verification component is configured to acquire verification information, and control the security lock to be unlocked in response to the verification information being preset information, and a first locking member is further disposed in the box body at a bottom thereof, and the first locking member protrudes downward from the bottom of the box body.

Abstract: Provided is a proximity ligation assay-based detection method for a high-order structure (HOS) of an RNA virus, including: mixing an RNA virus with a cross-linking agent, conducting cross-linking under ultraviolet (UV) light, and recovering the RNA virus to obtain a cross-linked RNA virus; extracting RNA of the cross-linked RNA virus; conducting fragmentation on the RNA with RNase III to obtain RNA fragments; ligating the RNA fragments and conducting decrosslinking to obtain decrosslinked RNA fragments; constructing a sequencing library for the decrosslinked RNA fragments; and conducting high-throughput sequencing on the sequencing library, and conducting an RNA HOS analysis on a sequencing result. In the present disclosure, high-efficiency short-distance ligation reaction is used to realize the cross-linking of RNA in virus particles in cell culture or collected supernatant, so as to analyze the HOS of RNA virus genome.

Abstract: Anti-IL-12/IL-23p40 antibodies, such as ustekinumab, are used in methods and compositions for safe and effective treatment of psoriasis, particularly moderate to severe chronic plaque psoriasis, in pediatric patients. The methods and compositions address a clear unmet medical need in this patient population.

Abstract: The present invention relates to compositions of peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salt or solvate forms thereof, corresponding pharmaceutical compositions, methods and/or uses for treatment of autoimmune inflammation and related diseases and disorders.

Abstract: Disclosed in embodiments of the present invention are a processing method and apparatus based on an interest tag, a device, and a storage medium. The method comprises: in a process of displaying an information flow in a preset application program, detecting that an interest tag display event is triggered; and displaying a first page, and dynamically switching and displaying, in the first page, different subsets in a preset interest tag set, wherein the number of interest tags in the subsets is more than one and is smaller than the total number of interest tags in the preset interest tag set.

Abstract: A bypass seamless switching apparatus and a method thereof are provided, in which a controller sends a first control signal to control or switch a first relay to on/off state, sends a second control signal to control or switch a second relay to on/off state, and sends a switch signal to control or switch a bypass switch module to on/off state. When the controller is in failure mode or is disconnected, a driving power supply of a bypass circuit provides a driving signal to the bypass switch module to maintain or switch a switch of the bypass switch module to on state, so that the bypass switch module is in short-circuit state or short-circuit protection state, and a bypass side voltage of the bypass switch module is equal to or close to zero voltage, so as to execute bypass function or bypass seamless switching function of the bypass switch module.

Abstract: Techniques are described for joint encoding and decoding of information symbols. In one embodiment, a method for joint encoding includes, in part, obtaining a sequence of information symbols, generating a plurality of cyclic codewords each corresponding to a portion of the sequence of information symbols, jointly encoding the plurality of cyclic codewords to generate at least one combined codeword, and providing the combined codeword to a device. The at least one combined codeword may be generated through Galois Fourier Transform (GFT).

Abstract: A semiconductor device is provided. The semiconductor device comprises a first semiconductor die comprising a first capacitor, and a second semiconductor die in contact with the first semiconductor die and comprises a diode. The first semiconductor die and the second semiconductor die are arranged along a first direction, and a diode is configured to direct electrons accumulated at the first capacitor to a ground.

Abstract: Disclosed is a charging station capable of realizing mutual capacity aid, which comprises a plurality of charging units, a power bus and a mutual capacity aid bus. Each charging unit is powered by the power bus, and each charging unit provides mutual aid capacity for another charging unit through the mutual capacity aid bus or receives mutual aid capacity from other charging units through the mutual capacity aid bus. The charging station can realize rapid charging of electric vehicles, and can also realize mutual capacity aid.

Abstract: A receiver optical sub-assembly, a combo bi-directional optical sub-assembly, a combo optical module, an optical line terminal, and a passive optical network system, where the receiver optical sub-assembly includes a first transistor-outline can, where a light incident hole is disposed on the first transistor-outline can, and where a first demultiplexer, a first optical receiver, a second optical receiver, and an optical lens combination are packaged in the first transistor-outline can.

Abstract: Provided are a method and a device for real-time monitoring of tunnel deformation. The monitoring method includes: S1, erecting a plurality of structured light sources in an unstable area to be monitored of a tunnel structure, and erecting a monitoring terminal in a relatively stable region of the tunnel structure, where the monitoring terminal may communicate with the plurality of structured light sources; S2, observing all structured lights in the unstable area of the tunnel structure and obtaining structured light curves in real time by the monitoring terminal; S3, analyzing imaging changes of the structured lights, detecting deformation degrees and offset distances of the tunnel in real time, and monitoring the diseases such as settlement, convergence of a single-section of the tunnel and integral settlement of a multi-section of the tunnel by the data processing unit.

Abstract: The disclosure describes a transgenic dicot or monocot plant having bovine milk protein(s) (e.g., bovine casein) and methods of producing the transgenic dicot or monocot plant containing bovine milk protein(s). These transgenic dicot or monocot plants can express and produce bovine milk protein(s) (e.g., bovine casein). The methods involve introducing a recombinant DNA construct expressing a bovine milk protein into a dicot or monocot plant, obtaining the dicot or monocot plant containing the bovine milk protein(s) from a recombinant DNA construct, cultivating and harvesting the transgenic dicot or monocot plant, and extracting and purifying the bovine milk protein(s) (e.g., bovine casein) from transgenic dicot or monocotyledonous plants. The disclosure also describes food compositions comprising milk proteins produced using the transgenic dicot or monocot plants described herein.

Abstract: This application discloses an optical splitting apparatus, an optical splitting system, a passive optical network, and an optical fiber fault detection method. The optical splitting apparatus includes a first optical splitting unit, a plurality of first optical path processing units, and a second optical path processing unit. The first optical splitting unit includes a first port and a plurality of second ports, and the first port is separately connected to the plurality of second ports.

Abstract: Provided are a method and a device for real-time monitoring of tunnel deformation. The monitoring method includes: S1, erecting a plurality of structured light sources in an unstable area to be monitored of a tunnel structure, and erecting a monitoring terminal in a relatively stable region of the tunnel structure, where the monitoring terminal may communicate with the plurality of structured light sources; S2, observing all structured lights in the unstable area of the tunnel structure and obtaining structured light curves in real time by the monitoring terminal; S3, analyzing imaging changes of the structured lights, detecting deformation degrees and offset distances of the tunnel in real time, and monitoring the diseases such as settlement, convergence of a single-section of the tunnel and integral settlement of a multi-section of the tunnel by the data processing unit.

Abstract: One embodiment facilitates measurement of a performance of a storage device. During operation, the system determines a normalized cost for an I/O request, wherein the normalized cost is independent of an access pattern and a type of the I/O request, wherein the normalized cost is indicated by a first number of virtual I/O operations consumed by the I/O request, and wherein a virtual I/O operation is used as a logical unit of cost associated with physical I/O operations. The system identifies a performance metric for the storage device by calculating a second number of virtual I/O operations per second which can be executed by the storage device. The system allocates incoming I/O requests to the storage device based on the performance metric, e.g., to satisfy a Quality of Service requirement, thereby causing an enhanced measurement of the performance of the storage device.

Abstract: A receiver optical sub-assembly, a combo bi-directional optical sub-assembly, a combo optical module, an optical line terminal, and a passive optical network system, where the receiver optical sub-assembly includes a first transistor-outline can, where a light incident hole is disposed on the first transistor-outline can, and where a first demultiplexer, a first optical receiver, a second optical receiver, and an optical lens combination are packaged in the first transistor-outline can.

Abstract: The present disclosure relates to a system and a method for data protection. In some embodiments, an exemplary method for data encoding includes: receiving a data bulk; performing an erasure coding (EC) encoding on the data bulk to generate one or more EC codewords; distributing a plurality of portions of each EC codeword of the one or more EC codewords across a plurality of solid-state drives (SSDs); performing, at each SSD of the plurality of SSDs, an error correction coding (ECC) encoding on portions of the one or more EC codewords distributed to the SSD to generate an ECC codeword; and storing, in each SSD of the plurality of SSDs, the ECC codeword.