Abstract: The present disclosure provides a display panel. The display panel comprises a base and a pixel driving circuit layer. The pixel driving circuit layer comprises a plurality of pixel driving circuits; the pixel driving circuit layer comprises a first semiconductor layer, a first insulating layer, and a second semiconductor layer stacked on the base. Wherein, the pixel driving circuit layer comprises first grooves located between the pixel driving circuits and opened in the first insulating layer, and a first organic spacer layer disposed in the first grooves.

Abstract: The application provides a flexible display panel and an electronic device. The flexible display panel includes a plurality of pixel groups. The pixel groups include a plurality of pixels arranged in a first direction. The flexible display panel also includes: a substrate; a semiconductor layer; a gate electrode; a metal part; and a first insulating layer arranged on the metal part. The first insulating layer is provided with at least one first groove, and a position of the first groove corresponds to a position of a gap between two adjacent pixel groups.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: Disclosed in the present invention is a polyamide 5X industrial yarn. The polyamide 5X industrial yarn has a heat-resistant break strength retention rate of 90% or more after being treated at 180° C. for 4 hrs; a heat-resistant break strength retention rate of 90% or more after being treated at 230° C. for 30 mins; and a dry heat shrinkage of 8.0% or less. The polyamide 5X industrial yarn is widely used in the fields of sewing threads, tire cords, air bag yarns, release cloth, krama, canvas, safety belts, ropes, fishing nets, industrial filter cloth, conveyor belts, parachutes, tents, bags and suitcases.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: A system for updating a hypercube includes an interface and a processor. The interface is configured to receive an indication to update a cell of the hypercube. The processor is configured to determine a primary dimension value associated with the cell; determine a group of dependencies based at least in part on the primary dimension value, wherein a dependency of the group of dependencies comprises one or more primary dimension values and a pattern; for the dependency of the group of dependencies, determine a set of source locations based at least in part on the one or more primary dimension values and the pattern; and mark the set of source locations as invalid.

Abstract: A system for caching includes an interface to receive a portion of a hypercube to evaluate. The hypercube includes cells with a set of the cells having a formula. The system includes a processor to determine term(s) in the formula for each cell of the set of cells; remove from consideration a time dimension and/or a primary dimension for the term(s) in the formula for each cell of the set of cells; determine a set of distinct terms using the term(s); determine whether a total number of terms in the set of cells is larger than a number of distinct terms in the set of distinct terms; and in response to determining that the total number of terms in the set of cells is larger than the number of distinct terms in the set of distinct terms, indicate to cache the set of distinct terms during evaluation.

Abstract: Embodiments of the disclosure concern methods and compositions for treatment of a cardiac-related medical condition. In particular embodiments, ANGPTL8 is provided to an individual in need thereof for the treatment or prevention of a cardiac-related medical condition. In certain cases, ANGPTL8 is provided to an individual with cardiomyopathy, such as Adriamycin-induced cardiomyopathy, using ultrasound-targeted microbubble destruction.

Abstract: Embodiments of the disclosure provide methods and/or compositions useful for an individual in need of treatment of a cardiac-related medical condition. In particular cases, GLP-1 is employed in a ultrasound targeted microbubble destruction (UTMD) system for delivery to cardiac tissue, thereby stimulating myocardial regeneration and, in at least some cases, reversal of cardiomyopathy.

Abstract: Embodiments of the disclosure provide methods and/or compositions useful for an individual in need of treatment of a cardiac-related medical condition. In particular cases, GLP-1 is employed in a ultrasound targeted microbubble destruction (UTMD) system for delivery to cardiac tissue, thereby stimulating myocardial regeneration and, in at least some cases, reversal of cardiomyopathy.

Abstract: The present invention includes compositions and methods for regenerating glucose-responsive cells by ultrasound-targeted microbubble destruction in the pancreas, wherein the composition comprises a pre-assembled liposome-nucleic acid complex in contact with within and about a microbubble, wherein the pre-assembled liposome-nucleic acid complex comprises a NeuroD gene under the control of the promoter, wherein disruption of the microbubble in the pancreas at a target site delivers the nucleic acid into pancreas cells at the location of the ultrasound disruption, wherein cells that incorporate the nucleic acid express insulin in response to high blood glucose levels.

Abstract: Embodiments of the present invention improve information exchange, and in particular, the exchange of data objects between different software systems. In one embodiment, the present invention includes a method of exchanging information comprising analyzing the attributes of the objects. Objects may be stored in a repository and retrieved using attributes. In some applications, objects are received and sent to participants without accessing any information in the objects themselves. Different applications include object warehousing operable across different communication mediums that support different names or name spaces, classes, aliases, groups, geospatial information, or tokens, or combinations thereof.

Abstract: The present invention includes compositions and methods for delivering one or more active agents in vivo by contacting a target organ or tissue with a microbubble encapsulated active agent comprising a neutrally charged lipid microbubble loaded with cationic liposomes comprising one or more active agents and selectively releasing the active agents at the target by exposing the microbubble at the target with ultrasound, wherein the active agents remain protected in the microbubble until selectively release at the target.

Abstract: The introduction of the human NeuroD1 gene into human non-endocrine pancreatic epithelial cells (NEPECs) for producing insulin producing cells in vitro is described herein. Cytokeratin19 (CK19) positive NEPECs were transfected with plasmids encoding human NeuroD1 gene under human CK19 promoter. On characterization following the induction it was found that NEPEC+ND strongly expressed NeuroD1 and insulin mRNA. The ratio of NeuroD1 and human insulin positive cells in NEPEC+ND was significantly higher than NEPEC. Human insulin and C-peptide levels in culture media in NEPEC+ND were significantly higher than NEPEC. The findings demonstrate that human NeuroD1 under control of the CK19 promoter induces the differentiation of CK19 positive NEPECs into insulin producing cells.

Abstract: The present invention includes compositions and methods for regenerating glucose-responsive cells by ultrasound-targeted microbubble destruction in the pancreas, wherein the composition comprises a pre-assembled liposome-nucleic acid complex in contact with in and about a microbubble, wherein the pre-assembled liposome-nucleic acid complex comprises a NeuroD gene under the control of the promoter, wherein disruption of the microbubble in the pancreas at a target site delivers the nucleic acid into pancreas cells at the location of the ultrasound disruption, wherein cells that incorporate the nucleic acid express insulin in response to high blood glucose levels.

Abstract: Embodiments of the present invention relate to an automated way for a non-technical person to create or modify software functionality in support of a business process without needing expertise in software. According to the invention, an automated matching tool may apply user input expressed semantically to a database of semantic information associated with syntactic information, to match the user input with a service (e.g., an application program) capable of performing a business process step corresponding to the input.

Abstract: An ultrasound-mediated gene transfer method named Ultrasound Targeted Microbubble Destruction (UTMD) for the delivery of human vascular endothelial growth factor (hVEGF) gene to transplanted islets and the surrounding tissue is described herein. The delivery of hVEGF promotes islet revascularization and survival. The inventors, first transplanted human islets were transplanted into diabetic nude mice liver followed by the induction of non-viral plasmid vectors encoding hVEGF or Green Fluorescent Protein (GFP) gene in the host liver by UTMD. Transplantation without gene delivery was also performed as a control. Blood glucose, serum human insulin, C-peptide levels and the revascularization in graft islets were evaluated. The findings of the method of the present invention indicated that hVEGF gene delivery to host liver using UTMD promoted islet revascularization after islet transplantation and improved the restoration of euglycemia.

Abstract: Embodiments of the present invention improve interactive audio task execution in mobile systems such as vehicles, for example. In one embodiment, task interrupt handling is provided to allow user's to resume task execution at or near the point in the task where the interrupt occurred. In one embodiment, a user's confidence that secondary tasks are being performed accurately is improved by providing confirmation and help for users to be more accurate on their secondary tasks. Accordingly, users can increase their confidence and trust in the system and focus more attention on primary tasks, such as driving a vehicle. Some embodiments of the invention further provide for more comprehensive confirmation following an interruption.

Abstract: Embodiments of the present invention provide improved event handling between systems. In one embodiment, the present invention includes software event handling method comprising receiving a first event from a first source system in a plurality of source systems, the first event including event information, accessing context information corresponding to the first event, generating a second event based on at least a portion of the event information and context information using one or more rules, assigning a priority to the second event, and sending the second event to a first target system in a plurality of target systems.