Patents by Inventor Shuaige Wang

Shuaige Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
    Patent number: 7524863
    Abstract: The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: April 28, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joanne M. Smallheer, Donald J. Pinto, Shuaige Wang, Jennifer X. Qiao, Wei Han, Zilun Hu
  • Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
    Patent number: 7157470
    Abstract: The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: January 2, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joanne M. Smallheer, Donald J. Pinto, Shuaige Wang, Jennifer X. Qiao, Wei Han, Zilun Hu
  • Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
    Publication number: 20060247243
    Abstract: The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: June 21, 2006
    Publication date: November 2, 2006
    Inventors: Joanne Smallheer, Donald Pinto, Shuaige Wang, Jennifer Qiao, Wei Han, Zilun Hu
  • Biarylmethyl indolines and indoles as antithromboembolic agents
    Patent number: 7129264
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or hydrate form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4 and W are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: October 31, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joanne M. Smallheer, Mimi L. Quan, Shuaige Wang, Gregory S. Bisacchi
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Patent number: 6951872
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: October 4, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Suanne Nakajima, Mimi L. Quan, Shuaige Wang, Joanne M. Smallheer, Jennifer Qiao
  • Biarylmethyl indolines, indoles and tetrahydroquinolines, useful as serine protease inhibitors
    Publication number: 20040220206
    Abstract: The present invention provides compounds of Formula (I): 1
    Type: Application
    Filed: April 14, 2004
    Publication date: November 4, 2004
    Inventors: Joanne M. Smallheer, Mimi L. Quan, Shuaige Wang, Gregory S. Bisacchi
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Publication number: 20040132718
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: 1
    Type: Application
    Filed: December 8, 2003
    Publication date: July 8, 2004
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Suanne Nakajima, Mimi L. Quan, Shuaige Wang, Joanne M. Smallheer, Jennifer X. Qiao
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Patent number: 6710058
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: March 23, 2004
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Shuaige Wang, Joanne M. Smallheer
  • Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
    Publication number: 20040006062
    Abstract: The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: 1
    Type: Application
    Filed: May 5, 2003
    Publication date: January 8, 2004
    Inventors: Joanne M. Smallheer, Donald J. Pinto, Shuaige Wang, Jennifer X. Qiao, Wei Han, Zilun Hu
  • Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
    Publication number: 20020183324
    Abstract: The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I: 1
    Type: Application
    Filed: October 29, 2001
    Publication date: December 5, 2002
    Inventors: Irina C. Jacobson, Ruth R. Wexler, Suanne Nakajima, Mimi L. Quan, Shuaige Wang, Joanne M. Smallheer, Jennifer Qiao
  • Isoxazoline fibrinogen receptor antagonists
    Patent number: 6476226
    Abstract: This invention relates to novel isoxazolines and isoxazoles of formula (I): or a pharmaceutically acceptable salt or prodrug form thereof. The invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: November 5, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Joanne M. Smallheer, Shuaige Wang, Prabhakar Kondaji Jadhav
  • Novel isoxazoline fibrinogen receptor antagonists
    Publication number: 20020094978
    Abstract: This invention relates to novel isoxazolines and isoxazoles of formula (I): 1
    Type: Application
    Filed: July 13, 2001
    Publication date: July 18, 2002
    Inventors: Joanne M. Smallheer, Shuaige Wang, Prabhakar Jadhav
  • Isoxazoline fibrinogen receptor antagonists
    Patent number: 6303609
    Abstract: This invention relates to novel isoxazolines and isoxazoles of formula (I): or a pharmaceutically acceptable salt or prodrug form thereof. The invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: October 16, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Joanne M. Smallheer, Shuaige Wang, Prabhakar Kondaji Jadhav