Abstract: The present invention relates to the combined use of: (a) the compound of formula (I) or a pharmaceutically acceptable salt thereof; and (b) PLD or a pharmaceutically acceptable salt thereof, for treating ovarian cancer.

Abstract: A method of preparing medical composition including hemp or Cannabis full plant extracts, cannabinoids, and one or more pharmaceutically acceptable excipients containing active pharmaceutical ingredients (APIs) can produce suppositories, patches, cream, lipstick or other skin care cosmetic. Cannabis, hemp plant chemicals and APIs can be delivered to one's bloodstream. The suppository composition is formulated for effective absorption through the mucosal membrane. The suppository is useful for the administration of medicine to treat pain, nausea, post-operative ileus, and/or inflammatory bowel diseases in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required.

Abstract: A process of converting cannabidiol (CBD) to ?8-tetrahydrocannabinol (?8-THC) or ?9-tetrahydrocannabinol (?9-THC) can enable mass production of ?8-THC and/or ?9-THC, achieve greater yields and higher purity in comparison to previously reported processes while eliminating the use of organic solvent. The resultant hemp-derived ?8-THC can be mixed with and absorbed by natural extracts, including tea extract, starch, sugar, lecithin, and other emulsifiers. ?8-THC used in edible, topical and vaping products such as powdered ?8-THC food ingredients, tablets or pills, suppositories, and vape formulations are disclosed. Further described are beverages and baked goods utilizing or incorporating the tablets or powdered ?8-THC to create edible products containing an emulsified, tasteless, and odorless dose of ?8-THC. The disclosure also describes a rectal suppository designed to provide improved comfort of use.

Abstract: A method for preparing a high molecular weight furan polyamide includes the following steps: 1) charging dimethyl furan dicarboxylate and aliphatic diamine into a reaction container at equal molar weight, and increasing the temperature to 60-120° C. under inert gas; 2) adding a catalyst when the reaction system becomes transparent liquid, increasing the temperature to 140-150° C., and keeping at an atmospheric pressure or a pressure of 41-61 kPa for 0-1 h; and then increasing the temperature to 190-200° C. and reacting for 1-3 h; and 3) depressurizing the system to 3-16 kPa for 0-3 h; and finally, reducing the pressure to 0.003-0.100 KPa for 1-3 h to obtain the high molecular weight furan polyamide.

Abstract: Systems and methods are described for providing dynamic guidance to purchasers using a fulfillment system to fulfill an order. The example systems can be configured to receive a request associated with an order and comprising an item identifier and an item quantity. The systems can estimate a request weight based on the item quantity and the item weight. The systems can also evaluate a request based on historical data associated with previous orders associated with the item identifier. The systems can select a dynamic default value based on the foregoing information and provide the dynamic default value for display to assist the purchaser.

Abstract: A method for preparing a high molecular weight furan polyamide includes the following steps: 1) charging dimethyl furan dicarboxylate and aliphatic diamine into a reaction container at equal molar weight, and increasing the temperature to 60-120° C. under inert gas; 2) adding a catalyst when the reaction system becomes transparent liquid, increasing the temperature to 140-150° C., and keeping at an atmospheric pressure or a pressure of 41-61 kPa for 0-1 h; and then increasing the temperature to 190-200° C. and reacting for 1-3 h; and 3) depressurizing the system to 3-16 kPa for 0-3 h; and finally, reducing the pressure to 0.003-0.100 KPa for 1-3 h to obtain the high molecular weight furan polyamide.

Abstract: The invention relates to a process for treatment of cellulosic material, for example, knitted or woven cotton fabric or yarn, comprising treating cellulosic material with a pectinase and a surfactant.

Abstract: A process for treatment of cellulosic material, for example, knitted or woven cotton fabric or yarn, comprises treating cellulosic material with a pectinase and a surfactant.

Abstract: A multi-target kinase inhibitor is shown in formula (I), in which R is selected from formula (a), formula (b), formula (c), formula (d), formula (e) and formula (f). The multi-target kinase inhibitor can effectively inhibit the enzymatic activities of RET, VEGFR3 and PDGFRA, and can effectively treat diseases that are regulated and controlled by multi-target kinases and are related to abnormal signal transduction pathways of the multi-target kinases, including cancers of breast, respiratory tract, brain, reproductive organ, digestive tract, urinary tract, eye, liver, skin, head and/or neck and distant metastatic cancers thereof, and lymphoma, sarcoma, leukemia and the like. The active ingredients of the pharmaceutical composition of the present invention comprise a multi-target kinase inhibitor, which accounts for 1-50 wt % of the composition.

Abstract: A method of preparing medical composition including hemp or Cannabis full plant extracts, cannabinoids, and one or more pharmaceutically acceptable excipients containing active pharmaceutical ingredients (APIs) can produce suppositories, patches, cream, lipstick or other skin care cosmetic. Cannabis, hemp plant chemicals and APIs can be delivered to one's bloodstream. The suppository composition is formulated for effective absorption through the mucosal membrane. The suppository is useful for the administration of medicine to treat pain, nausea, post-operative ileus, and/or inflammatory bowel diseases in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required.

Abstract: A process of converting cannabidiol (CBD) to ?8-tetrahydrocannabinol (?8-THC) or ?9-tetrahydrocannabinol (?9-THC) can enable mass production of ?8-THC and/or ?9-THC, achieve greater yields and higher purity in comparison to previously reported processes while eliminating the use of organic solvent. The resultant hemp-derived ?8-THC can be mixed with and absorbed by natural extracts, including tea extract, starch, sugar, lecithin, and other emulsifiers. ?8-THC used in edible, topical and vaping products such as powdered ?8-THC food ingredients, tablets or pills, suppositories, and vape formulations are disclosed. Further described are beverages and baked goods utilizing or incorporating the tablets or powdered ?8-THC to create edible products containing an emulsified, tasteless, and odorless dose of ?8-THC. The disclosure also describes a rectal suppository designed to provide improved comfort of use.

Abstract: A process for treatment of cellulosic material, for example, knitted or woven cotton fabric or yarn, comprises treating cellulosic material with a pectinase and a surfactant.

Abstract: A navigation apparatus and a method for updating map data thereof are provided. A map database of the navigation apparatus stores data of a plurality of existed roads. When coordinates of the navigation apparatus are not located on any one of the existed roads, a comparison module of the navigation apparatus determines whether the shortest distance between the coordinates and the existed roads exceeds a predetermined threshold. If the shortest distance exceeds the predetermined threshold, a map data adding module updates a traveling path according to a plurality of succeeding coordinates of the navigation apparatus until the navigation apparatus is determined to return on one of the existed roads. When the map data adding module finishes updating the traveling path, the map data adding module stores data of the traveling path in the map database of the navigation apparatus.

Abstract: A navigation apparatus and a method for updating map data thereof are provided. A map database of the navigation apparatus stores data of a plurality of existed roads. When coordinates of the navigation apparatus are not located on any one of the existed roads, a comparison module of the navigation apparatus determines whether the shortest distance between the coordinates and the existed roads exceeds a predetermined threshold. If the shortest distance exceeds the predetermined threshold, a map data adding module updates a traveling path according to a plurality of succeeding coordinates of the navigation apparatus until the navigation apparatus is determined to return on one of the existed roads. When the map data adding module finishes updating the traveling path, the map data adding module stores data of the traveling path in the map database of the navigation apparatus.

Abstract: A contact fuse is provided. The contact fuse includes a metal oxide semiconductor (MOS) transistor and a control circuit having outputs coupled to a plurality of terminals of the MOS transistor. The control circuit is operable to forward bias a body-source junction during a programming operation and operable to short the body-source junction during a sensing operation. A method of operating a contact fuse is also provided.

Abstract: An integrated circuit with electrically programmable fuse circuitry coupled to a programming transistor is provided. The programming transistor may be a metal-oxide-semiconductor transistor that is separated from other circuitry in an integrated circuit substrate with shallow trench isolation. The electrically programmable fuse circuitry may be formed in a second layer above the integrated circuit substrate using a conductive material which may be tungsten-based. This second layer may further include interconnect wires made from the same conductive material. The electrically programmable fuse may be coupled to the programming transistor through vias and routing paths in a fourth layer above the integrated circuit substrate. The routing paths in the fourth layer may be made from a conductive material which may be different than the fuse conductive material used to form the programmable fuse circuitry.

Abstract: Nonvolatile memory element circuitry is provided that is based on metal-oxide-semiconductor transistor structures. A nonvolatile memory element may be based on a metal-oxide-semiconductor transistor structure that has a gate, a drain, a source, and a body. During programming operations, control circuitry floats the body while applying a positive voltage to the drain and a negative voltage to the source. This causes the drain and source, which serve as the collector and emitter in a parasitic bipolar transistor, to break down. The drain-to-source (collector-to-emitter) breakdown causes sufficient current to flow through the source to alter the source electrode and thereby increase the resistance of the source significantly. During sensing operations, control circuitry may apply a voltage across the drain and source while grounding the body to determine whether the memory element has been programmed.

Abstract: Nonvolatile memory element circuitry is provided that is based on metal-oxide-semiconductor transistor structures. A nonvolatile memory element may be based on a metal-oxide-semiconductor transistor structure that has a gate, a drain, a source, and a body. During programming operations, control circuitry floats the body while applying a positive voltage to the drain and a negative voltage to the source. This causes the drain and source, which serve as the collector and emitter in a parasitic bipolar transistor, to break down. The drain-to-source (collector-to-emitter) breakdown causes sufficient current to flow through the source to alter the source electrode and thereby increase the resistance of the source significantly. During sensing operations, control circuitry may apply a voltage across the drain and source while grounding the body to determine whether the memory element has been programmed.

Abstract: An organic light emitting diode consisting of multiple organic layers, disposed between a transparent conducting anode and metallic cathode. The anode is provided with a metal fluoride layer to enhance the overall performance of the device, including higher power efficiency, lower voltage threshold and improved device operation stability.

Abstract: An organic light emitting diode consisting of multiple organic layers, disposed between a transparent conducting anode and metallic cathode. The anode is provided with a metal fluoride layer to enhance the overall performance of the device, including higher power efficiency, lower voltage threshold and improved device operation stability.