Patents by Inventor Shuangxi Wang

Shuangxi Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230398224
    Abstract: The present invention is directed to the bifunctional compounds and the use of such bifunctional compounds to lower plasma levels of extracellular target molecules by lysosomal degradation. Such bifunctional compounds have a cell surface receptor ligand covalently linked to a ligand that is capable of binding to an extracellular target molecule (such as a ligand for a growth factor, a cytokine, a chemokine, a hormone, a neurotransmitter, a capsid, a soluble receptor, an extracellular secreted protein, an antibody, a lipoprotein, an exosome, a virus, a cell, or a plasma membrane protein), where the cell surface receptor is associated with receptor mediated endocytosis, including asialoglycoprotein receptor (ASGPR) mediated lysosomal degradation and mannose-6-phosphate (M6PR) mediated lysosomal degradation.
    Type: Application
    Filed: February 4, 2021
    Publication date: December 14, 2023
    Inventors: Martin Allan, Jeffrey T. BAGDANOFF, David Weninger Barnes, Kevin Clairmont, Thomas Smith, Shuangxi Wang
  • Patent number: 10792361
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: October 6, 2020
    Assignee: NOVARTIS AG
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-Munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura West, Thomas Zabawa, Junping Zhao
  • Patent number: 10729775
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: August 4, 2020
    Assignee: NOVARTIS AG
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura Ellen West, Thomas Zabawa, Junping Zhao
  • Publication number: 20180369386
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Application
    Filed: August 29, 2018
    Publication date: December 27, 2018
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-Munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura West, Thomas Zabawa, Junping Zhao
  • Patent number: 10124065
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: November 13, 2018
    Assignee: Novartis AG
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-Munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura West, Thomas Zabawa, Junping Zhao
  • Publication number: 20180296677
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Application
    Filed: June 28, 2018
    Publication date: October 18, 2018
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura Ellen West, Thomas Zabawa, Junping Zhao
  • Patent number: 9783634
    Abstract: A method of making a fluorothieno[3,4-b]thiophene derivatives and photovoltaic polymers containing same using 3-bromothiophene-2-carboxylic acid as a starting material. This synthetic route provides an easier synthesis as well as greater yield and a purer product, which produces superior results over the prior art less pure products. The resulting materials can be used in a variety of photovoltaic applications and devices, especially solar cells.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: October 10, 2017
    Assignees: SOLARMER ENERGY, INC., PHILLIPS 66 COMPANY
    Inventors: Shuangxi Wang, Chenjun Shi, Ruby Chen, Junlian Zhang, Wei Wang, Yue Wu, Hui Huang, Amit Palkar, Ting He
  • Publication number: 20170196979
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Application
    Filed: September 27, 2016
    Publication date: July 13, 2017
    Applicant: Novartis AG
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura Ellen West, Thomas Zabawa, Junping Zhao
  • Patent number: 9504747
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 29, 2016
    Assignee: Novartis AG
    Inventors: Jeremy Lee Baryza, Rohan Eric John Beckwith, Keith Bowman, Crystal Byers, Tanzina Fazal, Gabriel Grant Gamber, Cameron Chuck-munn Lee, Ritesh Bhanudasji Tichkule, Chandra Vargeese, Shuangxi Wang, Laura Ellen West, Thomas Zabawa, Junping Zhao
  • Patent number: 9399730
    Abstract: This invention relates to an encapsulation structure comprising a luminescent wavelength conversion material for at least one solar cell or photovoltaic device which acts to enhance the solar harvesting efficiency of the solar cell device. The luminescent wavelength conversion material comprises at least one chromophore and an optically transparent polymer matrix. Application of the encapsulation structure, as disclosed herein, to solar harvesting devices, including solar cells, solar panels, and photovoltaic devices, improves the solar harvesting efficiency of the device by widening the spectrum of incoming sunlight that can be effectively converted into electricity by the device.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 26, 2016
    Assignee: Nitto Denko Corporation
    Inventors: Hongxi Zhang, Stanislaw Rachwal, Jie Cai, Yufen Hu, Michiharu Yamamoto, Zongcheng Jiang, Bogumila Rachwal, Shuangxi Wang, Peng Wang
  • Patent number: 9394479
    Abstract: Described herein are wavelength conversion films that are easy-to-apply to solar cells, solar panels, or photovoltaic devices using an adhesive layer. The wavelength conversion films include a wavelength conversion layer with a photostable chromophore and are useful for improving the solar harvesting efficiency of solar cells, solar panels, and photovoltaic devices.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 19, 2016
    Assignee: Nitto Denko Corporation
    Inventors: Hongxi Zhang, Stanislaw Rachwal, Jie Cai, Yufen Hu, Michiharu Yamamoto, Zongcheng Jiang, Bogumila Rachwal, Shuangxi Wang, Peng Wang
  • Publication number: 20160106842
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Application
    Filed: March 6, 2014
    Publication date: April 21, 2016
    Inventors: Jeremy Lee BARYZA, Rohan Eric John BECKWITH, Keith BOWMAN, Crystal BYERS, Tanzina FAZAL, Gabriel Grant GAMBER, Cameron Chuck-Munn LEE, Ritesh Bhanudasji TICHKULE, Chandra VARGEESE, Shuangxi WANG, Laura WEST, Thomas ZABAWA, Junping ZHAO
  • Patent number: 9287419
    Abstract: This invention is related to novel perylene diester derivatives represented by the general formula (I) or general formula (II) as described herein. The derivatives are useful in various applications, such as luminescent dyes for optical light collection systems, fluorescence-based solar collectors, fluorescence-activated displays, and/or single-molecule spectroscopy. The invention also relates to a luminescent medium, such as a luminescent film, that can significantly enhance the solar harvesting efficiency of thin film CdS/CdTe or CIGS solar cells. The luminescent medium comprises an optically transparent polymer matrix and at least one luminescent dye that comprises a perylene diester derivative. Over 16% of an efficiency enhancement to a CdS/CdTe solar cell and over 12% of an efficiency enhancement to a CIGS solar cell can be achieved.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: March 15, 2016
    Assignee: Nitto Denko Corporation
    Inventors: Zongcheng Jiang, Bogumila Rachwal, Hongxi Zhang, Peng Wang, Michiharu Yamamoto, Shuangxi Wang
  • Publication number: 20150210800
    Abstract: A method of making a fluorothieno[3,4-b]thiophene derivatives and photovoltaic polymers containing same using 3-bromothiophene-2-carboxylic acid as a starting material. This synthetic route provides an easier synthesis as well as greater yield and a purer product, which produces superior results over the prior art less pure products. The resulting materials can be used in a variety of photovoltaic applications and devices, especially solar cells.
    Type: Application
    Filed: March 6, 2015
    Publication date: July 30, 2015
    Applicants: Phillips 66 Company, Solarmer Energy, Inc.
    Inventors: Shuangxi Wang, Chenjun Shi, Ruby Chen, Junlian Zhang, Wei Wang, Yue Wu, Hui Huang, Amit Palkar, Ting He
  • Patent number: 9006568
    Abstract: A method of making a fluorothieno[3,4-b]thiophene derivatives and photovoltaic polymers containing same using 3-bromothiophene-2-carboxylic acid as a starting material. This synthetic route provides an easier synthesis as well as greater yield and a purer product, which produces superior results over the prior art less pure products. The resulting materials can be used in a variety of photovoltaic applications and devices, especially solar cells.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: April 14, 2015
    Assignees: Phillips 66 Company, Solarmer Energy, Inc.
    Inventors: Shuangxi Wang, Chenjun Shi, Ruby Chen, Junlian Zhang, Hui Huang, Yue Wu, Wei Wang, Amit Palkar, Ting He
  • Publication number: 20140303232
    Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
    Type: Application
    Filed: March 7, 2014
    Publication date: October 9, 2014
    Applicant: NOVARTIS AG
    Inventors: Jeremy Lee BARYZA, Rohan Eric John BECKWITH, Keith BOWMAN, Crystal BYERS, Tanzina FAZAL, Gabriel Grant GAMBER, Cameron Chuck-munn LEE, Ritesh Bhanudasji TICHKULE, Chandra VARGEESE, Shuangxi WANG, Laura Ellen West, Thomas ZABAWA, Junping ZHAO
  • Patent number: 8674103
    Abstract: Compounds derived from aromatic tetracarboxyl bisbenzoimidazoles are disclosed. These compounds are capable of forming liquid crystal systems that can produce optically isotropic or anisotropic films with desirable optical properties. Formulae (I) or (II), or a salt thereof; wherein y is an integer in the range from 0 to about 4.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: March 18, 2014
    Assignee: Nitto Denko Corporation
    Inventors: Robert Ramirez, Shijun Zheng, Zongcheng Jiang, Shuangxi Wang, Michiharu Yamamoto
  • Publication number: 20130284265
    Abstract: This invention is related to novel perylene diester derivatives represented by the general formula (I) or general formula (II) as described herein. The derivatives are useful in various applications, such as luminescent dyes for optical light collection systems, fluorescence-based solar collectors, fluorescence-activated displays, and/or single-molecule spectroscopy. The invention also relates to a luminescent medium, such as a luminescent film, that can significantly enhance the solar harvesting efficiency of thin film CdS/CdTe or CIGS solar cells. The luminescent medium comprises an optically transparent polymer matrix and at least one luminescent dye that comprises a perylene diester derivative. Over 16% of an efficiency enhancement to a CdS/CdTe solar cell and over 12% of an efficiency enhancement to a CIGS solar cell can be achieved.
    Type: Application
    Filed: January 4, 2012
    Publication date: October 31, 2013
    Applicant: NITTO DENKO CORPORATION
    Inventors: Zongcheng Jiang, Rachwal Bogumila, Hongxi Zhang, Peng Wang, Michiharu Yamamoto, Shuangxi Wang
  • Publication number: 20130214213
    Abstract: A method of making a fluorothieno[3,4-b]thiophene derivatives and photovoltaic polymers containing same using 3-bromothiophene-2-carboxylic acid as a starting material. This synthetic route provides an easier synthesis as well as greater yield and a purer product, which produces superior results over the prior art less pure products. The resulting materials can be used in a variety of photovoltaic applications and devices, especially solar cells.
    Type: Application
    Filed: February 12, 2013
    Publication date: August 22, 2013
    Applicants: Solarmer Energy, Inc., Phillips 66 Company
    Inventors: Shuangxi Wang, Chenjun Shi, Ruby Chen, Junlian Zhang, Hui Huang, Yue Wu, Wei Wang, Amit Palkar, Ting He
  • Publication number: 20110317102
    Abstract: Compounds derived from aromatic tetracarboxyl bisbenzoimidazoles are disclosed. These compounds are capable of forming liquid crystal systems that can produce optically isotropic or anisotropic films with desirable optical properties. Formulae (I) or (II), or a salt thereof; wherein y is an integer in the range from 0 to about 4.
    Type: Application
    Filed: February 24, 2010
    Publication date: December 29, 2011
    Applicant: NITTO DENKO CORPORATION
    Inventors: Robert Ramirez, Shijun Zheng, Zongcheng Jiang, Shuangxi Wang, Michiharu Yamamoto