Abstract: The present invention relates to a method of analyzing a composition of nucleic acids derived from a single cell using a microplate including a plurality of reaction wells, the microplate having one bead arranged in one reaction well, the one bead having bound thereto a plurality of molecules of single-stranded oligonucleotides, the single-stranded oligonucleotides each having a nucleic acid capture sequence exposed at the 3? end and a barcode sequence on the 5? side of the nucleic acid capture sequence, the barcode sequence including a base sequence that differs from bead to bead.

Abstract: The present invention relates to an antiviral drug comprising as an active ingredient a substance capable of suppressing an expression of a target gene or an activity of a protein encoded by said target gene, wherein said target gene is one or more genes having an action of retaining virus-derived nucleic acid in a host cell and selected from the group consisting of DOCK11 gene, LIPG gene, DENND2A gene, and HECW2 gene. The present invention also relates to a screening method for the antiviral drug.

Abstract: A tire molding element for vulcanization molding a tire tread is disclosed herein. The tire includes at least one thin plate including a protrusion which protrudes from the main body in the thickness direction of the thin plate and guides the cut covering layer in the depth direction of the green tire in such a way as to cover at least a portion of the transverse side surface of the ground contact element, and the at least one thin plate comprises at least two cutting means separated in the thickness direction of the at least one thin plate, at an end portion on the opposite side to the molding surface.

Abstract: The present invention relates to an antiviral drug comprising as an active ingredient a substance capable of suppressing an expression of a target gene or an activity of a protein encoded by said target gene, wherein said target gene is one or more genes having an action of retaining virus-derived nucleic acid in a host cell and selected from the group consisting of DOCK11 gene, LIPG gene, DENND2A gene, and HECW2 gene. The present invention also relates to a screening method for the antiviral drug.

Abstract: A tread made of rubber material for a snow tire having a tread surface intended to be in contact with a road surface when the tire is being driven on, and provided with a plurality of cuts delimited by walls situated facing one another and forming lateral walls of raised elements of the tread. Each lateral wall intersects the tread surface to form an edge corner. At least one lateral wall of a raised element is formed partially or fully by a cover layer extending from the edge corner associated with this lateral wall, of a material having an elastic modulus higher than that of the rubber material of the tread. The raised element has a depression in its lateral wall, delimited by the cover layer. The raised element moreover has a width W and the depth P of the depression is at least equal to 10% of the width W of the element and less than or equal to 40% of this width W. Finally the volume of the depression is less than 10% of the volume of the raised element.

Abstract: A tire molding element for vulcanization molding a tire tread is disclosed herein. The tire includes at least one thin plate including a protrusion which protrudes from the main body in the thickness direction of the thin plate and guides the cut covering layer in the depth direction of the green tire in such a way as to cover at least a portion of the transverse side surface of the ground contact element, and the at least one thin plate comprises at least two cutting means separated in the thickness direction of the at least one thin plate, at an end portion on the opposite side to the molding surface.

Abstract: The tire tread according to the present disclosure includes a plurality of ground contact elements which are defined by a plurality of grooves formed on a ground contact surface in contact with a road surface when the tire is rolling, and having an upper surface forming a portion of the ground contact surface; and a plurality of small recesses which open at the upper surface, are indented inwardly in the tire radial direction, and are not in communication with each other, the depth h of the small recesses being between 0.15 mm and 1.5 mm when the tread is brand new.

Abstract: Disclosed herein is a tire molding element. The tire molding element includes at least a molding surface for molding a plurality of ground contact elements of the tire tread, comprising: a ground contact surface which contacts a road surface, and a transverse side surface and a circumferential side surface connected to said ground contact surface; and a plurality of thin plates, comprising: a main body, provided in such a way as to cut a covering layer arranged in advance on an unvulcanized green tire.

Abstract: The disclosure relates to a molding element including a main lamella and two ribs positioned on either side of the main lamella at a certain distance from this main lamella. The ribs are mold-able to grooves in the tread, these ribs including rounded ends. The main lamella includes a cutting edge, the cutting edge making an acute angle. The ribs are curved in their length with a curvature C and in that the lamella is curved with the same curvature C.

Abstract: A tread made of rubber-like material for a tire for winter travel having a plurality of blocks of a height H, each block comprising a contact face designed to come into contact with the ground when the tire travels and at least one lateral face, said lateral face being covered by a layer of covering material over at least 50% of the surface thereof, and a leading zone designed to come into contact first with the ground when the tire travels, and said block has an oblique direction of extension (J) such that the leading zone of said block is a leading corner, and a part which is not covered by the covering material, said covering material having a modulus of elasticity which is greater than the modulus of elasticity of the rubber-like material forming the block, said uncovered part extending from the leading corner over at least ? of the height H of the block.

Abstract: The present invention relates to a method of analyzing a composition of nucleic acids derived from a single cell using a microplate including a plurality of reaction wells, the microplate having one bead arranged in one reaction well, the one bead having bound thereto a plurality of molecules of single-stranded oligonucleotides, the single-stranded oligonucleotides each having a nucleic acid capture sequence exposed at the 3? end and a barcode sequence on the 5? side of the nucleic acid capture sequence, the barcode sequence including a base sequence that differs from bead to bead.

Abstract: A mold element for molding and vulcanizing a tire tread having a plurality of raised elements, each raised element having a contact face intended to come into contact with a road surface and lateral faces connected thereto. The mold element comprises cutting blades able to cut a cover layer already applied to a green form of the tire. Each cutting blade comprises a body, at least one of the cutting blades comprises a protrusion projecting from this body, able to drive a cut part of the cover layer into the depth of the green tire to cover all or part of a lateral face of a raised element. The cutting blade comprises, at one end of the body, a cutting edge forming an acute angle ? for cutting the cover layer.

Abstract: Nitride semiconductor devices having interdigitated array source and drain electrodes arranged like crossed fingers are described. The electric fields extended at the tips of the array electrodes are relaxed. Desirably, the rounded source electrode tip ends have a larger effective diameter than the rounded tip ends of the drain electrodes. Devices constructed accordingly have higher withstand voltages.

Abstract: Semiconductor devices and methods are described wherein temperature dependence of leakage current in at least one pathway of a device is compensated by a resistor in the device. Control of temperature dependent leakage current is particularly useful for silicon nitride devices and for circuits such as cascode circuits. A semiconductor leakage current that increases with temperature may be compensated by a fabricated resistor such as a boron doped polysilicon resistor that is electrically connected to compensate the leakage current in the pathway.

Abstract: The disclosure relates to a molding element of a mold for molding and vulcanizing a tire tread, this tread comprising a tread surface intended to come into contact with the ground when the said tire is running. The molding element includes a rib for molding a groove in the tire tread, the rib being a rounded end.

Abstract: The tire tread has a ground-contact surface and a main groove, secondary grooves; and blocks. The blocks are each provided with an upper surface, front-surface side walls, side-surface side walls, front-surface edges formed in positions where the upper surface intersects the front-surface side walls and side-surface edges formed in positions where the upper surface intersects the side-surface side walls. The blocks each have a reinforcement section with an average thickness of t and an elastic modulus (Ef) higher than the elastic modulus (Et) of a rubber composition forming the tread. An undulating section with ridge sections and a valley section is formed in the front-surface side wall. The undulating section is provided so as to form at least a portion of the at least one front-surface side wall having the reinforcement section provided thereto, and so as to form at least a portion of the reinforcement section.

Abstract: The disclosure concerns a tread band for a tire, said tread band having two sides with a predetermined distance D between these two sides and a centre. Indeed the tread band has a plurality of blocks, each block extending continuously in a curved manner to one side of the tread band towards the centre of this tread band with no groove separating this block in different parts, the block following a certain curvature C. All or part of the blocks of the plurality of blocks include a main sipe extending in the block and following the same curvature C, this sipe separating the block in two half parts.

Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects.

Abstract: The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects.

Abstract: The disclosure relates to a molding element of a mold for molding and vulcanizing a tire tread, this tread comprising a tread surface intended to come into contact with the ground when the said tire is running. The molding element includes a rib for molding a groove in the tire tread, the rib being a rounded end.