Patents by Inventor Shuji Miyagawa

Shuji Miyagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HLA-E chimeric molecule
    Patent number: 9175064
    Abstract: HLA-E chimeric molecules for providing nonhuman mammalian cells resistant to cytotoxic human NK cells, nucleotide sequences encoding these chimeric molecules, and nonhuman mammalian cells and nonhuman mammals transformed with such nucleotide sequences are disclosed herein. The HLA-E chimeric molecules of the invention contain a peptide that reforms all or part of the signal peptide region, ?1 domain and/or ?2 domain of HLA-E, and a nucleotide sequence of the invention encodes a HLA-E chimeric molecule. A transformant incorporating a nucleotide sequence of the invention expresses HLA-E efficiently.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: November 3, 2015
    Inventors: Shuji Miyagawa, Katsuyoshi Matsunami
  • Hla-E Chimeric Molecule
    Publication number: 20070259403
    Abstract: The invention presents HLA-E chimeric molecules for providing nonhuman mammal cell with resistance to cytotoxicity by human NK cell, base sequences for coding the chimeric molecules, and nonhuman mammal cell and nonhuman mammal animal transformed by the base sequences. The HLA-E chimeric molecule of the invention is a peptide reforming all or part of signal peptide region, ?1 domain and/or ?2 domain of HLA-E, and the base sequence of the invention is a base sequence for coding the chimeric molecule. The transformant incorporating the base sequence of the invention is effective to express the HLA-E efficiently.
    Type: Application
    Filed: November 4, 2004
    Publication date: November 8, 2007
    Applicant: The Animal Engineering Research Institute
    Inventors: Shuji Miyagawa, Katsuyoshi Matsunami
  • Modified CRE recombinase gene for mammals
    Patent number: 6734295
    Abstract: An object of the present invention is to provide a modified gene for mammals having expression level, in mammalian cells, tissues, organs or bodies, several times as high as that of phage-derived Cre recombinase. To attain the aforementioned object, the present invention provides a modified Cre recombinase gene for mammals consisting of codons frequently used in mammalian cells.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: May 11, 2004
    Assignee: President of Osaka University
    Inventors: Shuji Miyagawa, Masaru Okabe
  • Membrane-bound C1 inhibitor
    Patent number: 6500929
    Abstract: The present invention provides an mbCRP capable of effectively suppressing complement activity and completely inhibiting generation of intermediates damaging a transplanted tissue during the complement activation. To be more specific, the present invention provides a membrane-bound C1 inhibitor comprising a protein containing a functional domain of a water-soluble C1 inhibitor and an anchor molecule attached to an end and/or an interior of the protein.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: December 31, 2002
    Assignee: President of Osaka University
    Inventor: Shuji Miyagawa