Abstract: The present application provides a frame structure configuration method, a frame structure configuration apparatus, an electronic device and a computer readable storage medium, the frame structure configuration method includes: obtaining a real-time distance between a base station and a terminal; determining the number of time slots occupied by a guard period (GP) according to the real-time distance and a propagation speed of a wireless signal; and according to the number of the time slots occupied by the GP, the number of uplink time slots and the number of downlink time slots, determining an adaptive frame structure for data transmission between the base station and the terminal.

Abstract: Disclosed is a low-posture zero-gravity seat frame capable of being adjusted in multiple directions. A first left front connecting rod has a lower end hinged to a left slide rail front bracket and an upper end hinged to one end of a second left front connecting rod, and the other end of the second left front connecting rod is hinged to a front horizontal tube. A second toothed plate driving device is able to adjust the height of a seat framework through the movement of a rear horizontal tube. A seatbelt retractor is disposed below the seat framework. The seat frame can realize zero-gravity adjustment, occupies a small space, and can fulfill low-posture seat arrangement.

Abstract: Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.

Abstract: Provided herein are anti-FGL2 monoclonal antibodies. Further provided herein are methods to reverse suppressive immune mechanisms, such as for the treatment of cancer or infectious diseases.

Abstract: Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.

Abstract: A large-scale axle intelligent cross wedge rolling mill for rail transit includes a main transmission device, a memorial arch unit, two worm-gear pressing devices, a roll assembly and two guide devices. The separation sleeves are engaged with the upper slide shaft and the lower slide shaft, respectively. Two lower shaft necks are detachably connected with the left end surface and the right end surface of the lower roller, respectively; two upper shaft necks are detachably connected with the left end surface and the right end surface of the upper roller, respectively, so that the quick disconnection of the upper and lower rollers with the upper and lower shaft necks is able to be achieved, so as to quickly operate and install the roll to meet the requirement of quick mold replacement, thus improving the flexibility of rolling.

Abstract: Provided herein are chimeric antigen receptor (CAR)-like constructs comprising tumor-targeted and membrane-anchored IL-12. Also provided herein are T cells expressing the CAR-like IL-12 construct. Further, methods of treating cancer comprising administering T cells expressing CAR-like IL-12 are provided herein.

Abstract: Provided herein is an FGL2 neutralization cell therapy comprising immune cells expressing a FGL2 neutralization construct. Further provided are methods for the treatment of cancer comprising administering the FGL2 neutralization cell therapy.

Abstract: Provided herein are anti-FGL2 monoclonal antibodies. Further provided herein are methods to reverse suppressive immune mechanisms, such as for the treatment of cancer or infectious diseases.

Abstract: Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.

Abstract: The present invention includes the discovery of cell-surface vimentin as a novel biomarker to detect and isolate mesenchymal and epithelial-mesenchymal transformed circulating tumor cells from blood of cancer patients. In addition, an antibody specific for the detection of cell-surface vimentin on circulating tumor cells and the use the antibody to detect, enumerate, and isolate CTC are provided.

Abstract: A mini-peptide and its analogs have been found to target gene products to tumors. The peptide, named Carcinoma Homing Peptide (CHP), increased the tumor accumulation of the reporter gene products in five independent tumor models, including one human xenogeneic model. A CHP-IL-12 fusion gene was also developed using CHP and the p40 subunit of IL-12. The product from CHP-IL-12 fusion gene therapy increased accumulation of IL-12 in the tumor environment. In three tumor models. CHP-IL-12 gene therapy inhibited distal tumor growth. In a spontaneous lung metastasis model, inhibition of metastatic tumor growth was improved compared to wild-type IL-12 gene therapy, and in a squamous cell carcinoma model, toxic liver lesions were reduced. The receptor for CHP was identified as vimentin. CHP can be used to improve the efficacy and safety of targeted cancer treatments.

Abstract: A mini-peptide and its analogs have been found to target gene products to tumors. The peptide, named Carcinoma Homing Peptide (CHP), increased the tumor accumulation of the reporter gene products in five independent tumor models, including one human xenogeneic model. A CHP-IL-12 fusion gene was also developed using CHP and the p40 subunit of IL-12. The product from CHP-IL-12 fusion gene therapy increased accumulation of IL-12 in the tumor environment. In three tumor models, CHP-IL-12 gene therapy inhibited distal tumor growth. In a spontaneous lung metastasis model, inhibition of metastatic tumor growth was improved compared to wild-type IL-12 gene therapy, and in a squamous cell carcinoma model, toxic liver lesions were reduced. The receptor for CHP was identified as vimentin. CHP can be used to improve the efficacy and safety of targeted cancer treatments.

Abstract: The present invention includes the discovery of cell-surface vimentin as a novel biomarker to detect and isolate mesenchymal and epithelial-mesenchymal transformed circulating tumor cells from blood of cancer patients. In addition, an antibody specific for the detection of cell-surface vimentin on circulating tumor cells and the use the antibody to detect, enumerate, and isolate CTC are provided.

Abstract: A mini-peptide and its analogs have been found to target gene products to tumors. The peptide, named Carcinoma Homing Peptide (CHP), increased the tumor accumulation of the reporter gene products in five independent tumor models, including one human xenogeneic model. A CHP-IL-12 fusion gene was also developed using CHP and the p40 subunit of IL-12. The product from CHP-IL-12 fusion gene therapy increased accumulation of IL-12 in the tumor environment. In three tumor models, CHP-IL-12 gene therapy inhibited distal tumor growth. In a spontaneous lung metastasis model, inhibition of metastatic tumor growth was improved compared to wild-type IL-12 gene therapy, and in a squamous cell carcinoma model, toxic liver lesions were reduced. The receptor for CHP was identified as vimentin. CHP can be used to improve the efficacy and safety of targeted cancer treatments.

Abstract: The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide-nucleic acid conjugate. The conjugate is able to simultaneously activate multiple death signaling mechanisms. Methods of using the conjugate of the present invention as an immunotherapeutic modality for the treatment or prevention of infectious disease, neoplastic diseases or other disorders.

Abstract: It has been discovered that a sequential administration by intramuscular electroporation of the gene for IL12 followed about 10 days later by the gene for IL27 eradicated tumors in 33% of mice with aggressive 4T1 breast malignancy. In addition, the mice in which the initial tumor was eradicated rejected subsequent challenges with tumor cells. This simple sequential cytokine gene therapy can be used for treating residual malignancy and for inhibiting metastatic tumors. Tumors that respond to this treatment were shown to have the WSX-1 subunit of the IL27 receptor. The responsiveness of tumors containing WSX-1 to the dual IL12?IL27 therapy suggests that WSX-1 receptor may be used as a marker for selection of sensitive populations of tumor cells. Stat1 phosphorylation was shown to be a useful measure for WSX-1 activation in a panel of various cancer cells.

Abstract: The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide-nucleic acid conjugate. The conjugate is able to simultaneously activate multiple death signaling mechanisms that are specifically targeted to neoplastic cells, including tumor cells. Methods of using the conjugate of the present invention as an immunotherapeutic modality for the treatment or prevention of neoplastic diseases or other disorders is also disclosed. Further, methods are disclosed for identifying such conjugates by assaying test agents for various cytotoxic responses, including the induction of hyperfusion between neoplastic cells in vitro.

Abstract: Uridine phosphorylase is a reliable molecular marker to predict the response of cancer, e.g., squamous cell carcinoma, to treatment with a chemotherapeutic agent or radiation therapy or concomitant treatment with both. Surprisingly, this molecular marker by itself is more accurate than other well-known molecular markers for the prediction of the concomitant chemoradiation response. This marker may be used as a prognostic factor on several types of cancers, including head and neck cancer, skin cancer, ovarian cancer, lung cancer, colon cancer, esophageal cancer, melanoma, and adenocarcinoma. The expression profile of eleven genes may be used to predict the response of cancer cells to chemoradiation therapy.

Abstract: The present invention is directed to the identification of prognostic molecular markers of cancer and methods of predicting treatment response of a cancer. The invention further discloses molecular chips useful in predicting whether a cancer will respond to treatment. Preferably, the treatment is radiation therapy. Methods of using and methods of making the molecular chips of the invention are also disclosed.