Abstract: Provided is a method for treating cancer by administering to a subject in need thereof with a pharmaceutical composition including a benzenesulfonamide derivative in combination with a cancer immunotherapeutic agent such as the immune check point inhibitor (ICI).

Abstract: Provided is a method for treating cancer by administering to a subject in need thereof with a pharmaceutical composition including a benzenesulfonamide derivative and at least one other therapeutic agents in a different classification of anticancer agents.

Abstract: Provided is a pharmaceutical composition for treating melanoma, including a benzenesulfonamide derivative and a pharmaceutically acceptable carrier thereof. Also provided is a method for treating melanoma by administering the composition to a subject in need thereof. Further provided is a use of the pharmaceutical composition in the manufacture of a medicament for treating melanoma.

Abstract: Provided is a composition for reducing fat in the body of a subject, including a benzenesulfonamide derivative and a pharmaceutically or cosmetically acceptable carrier thereof. Also provided is a method for fat ablation or lipolysis by administering the composition to the subject in need thereof. Further provided is a method for preventing or treating a disease or condition related to fat accumulation by administering the composition to the subject in need thereof.

Abstract: The present disclosure provides a method for queuing and a related electronic device. The method for queuing in the present disclosure includes: receiving user data of a user; receiving a current serial number and a quantity of queued people of a service station; determining a queuing time based on the current serial number, the quantity of queued people, and a serial number of the user data; receiving a quantity of waiting people of a first stop in response to a first demand value of the user data being true; determining a first waiting time based on the quantity of waiting people of the first stop; and transmitting a first signal of going to the first stop to the user, and queuing the user in a queue of the service station and a queue of the first stop, in response to the first waiting time being less than the queuing time.

Abstract: Provided is a pharmaceutical composition for treating melanoma, including a benzenesulfonamide derivative and a pharmaceutically acceptable carrier thereof. Also provided is a method for treating melanoma by administering the composition to a subject in need thereof. Further provided is a use of the pharmaceutical composition in the manufacture of a medicament for treating melanoma.

Abstract: Provided is a composition for reducing fat in the body of a subject, including a benzenesulfonamide derivative and a pharmaceutically or cosmetically acceptable carrier thereof. Also provided is a method for fat ablation or lipolysis by administering the composition to the subject in need thereof. Further provided is a method for preventing or treating a disease or condition related to fat accumulation by administering the composition to the subject in need thereof.

Abstract: Provided is a method for preparing a tissue section, including treating a tissue specimen with a clearing agent and at least one labeling agent to obtain a cleared and labeled tissue specimen; generating a three-dimensional (3D) image of the cleared and labeled tissue specimen; performing an image slicing procedure on the 3D image to generate a plurality of two-dimensional (2D) images; identifying a target 2D image among the plurality of 2D images to obtain a distance value of D1, which indicates the distance between the target 2D image and a predetermined surface of the 3D image; preparing a hardened tissue specimen from the cleared and labeled tissue specimen; and cutting the hardened tissue specimen near a predetermined site to obtain a tissue section, wherein the distance between the predetermined site and a surface of the hardened tissue specimen corresponding to the predetermined surface of the 3D image is Dl.

Abstract: The invention provides a 3D histopathology imaging method. The method includes collecting a tissue specimen from a subject, staining the tissue so as to obtain a stained tissue, obtaining, by a microscopy, a 3D image of the stained tissue, and performing an image slicing procedure on the 3D image to generate a plurality of 2D images.

Abstract: The present disclosure relates to a benzenesulfonamide derivative which is useful to modulate lipid raft integrity of cancer cells and the use of the benzenesulfonamide derivative in prevention or treatment of diseases or conditions which can be ameliorated by change of the lipid raft integrity in a subject.

Abstract: Provided is a topical formulation for preventing or treating acne, including a benzenesulfonamide derivative, and a pharmaceutically or cosmetically acceptable excipient. Also provided is a method for preventing or treating acne, including applying the topical formulation on skin of a subject in need thereof.

Abstract: Provided are benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof. Also provided is a method for treating cancer by using a pharmaceutical composition including the benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carriers.

Abstract: Provided are benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof. Also provided is a method for treating cancer by using a pharmaceutical composition including the benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carriers.

Abstract: Provided is a topical formulation for preventing or treating acne, including a benzenesulfonamide derivative, and a pharmaceutically or cosmetically acceptable excipient. Also provided is a method for preventing or treating acne, including applying the topical formulation on skin of a subject in need thereof.

Abstract: Provided are benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof. Also provided is a method for treating cancer by using a pharmaceutical composition including the benzenesulfonamide derivatives or pharmaceutically acceptable salts thereof and pharmaceutically acceptable carriers.

Abstract: A system and methods are provided for collecting, analyzing, and reporting data supplied on the report data stream of an electronic switching system or other generator of a report or log data stream or file. Local data storage facilities are provided to receive and store report data stream information for one or more switches. A centralized data storage and analysis facility receives the data collected by the local facilities. A parser parses the collected report data to select and reformat report items of interest according to predefined selection triggers. A post processing facility includes pattern identification and pattern classification components. The pattern identification component reads the parsed, selected report items and extracts a pattern comprising the selection triggers and function call addresses associated with each event. The pattern classification component determines whether the identified pattern for each event is old or newly encountered.