Patents by Inventor Shuvo Roy
Shuvo Roy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090131858Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.Type: ApplicationFiled: January 10, 2008Publication date: May 21, 2009Applicant: The Regents of the University of MichiganInventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
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Patent number: 7491179Abstract: An apparatus (10) that utilizes microelectromechanical systems (MEMS) technology to provide an in vivo assessment of loads on adjacent bones (24 and 26) comprises a body (34) for insertion between the adjacent bones. At least one sensor (42) is associated with the body (34). The sensor (42) generates an output signal in response to and indicative of a load being applied to the body (34) through the adjacent bones (24 and 26). A telemetric device (40) is operatively coupled with the sensor (42). The telemetric device (40) is operable to receive the output signal from the sensor (42) and to transmit an EMF signal dependent upon the output signal. According to various aspects of the invention, the sensor comprises a pressure sensor (42), a load cell (320), and/or at least one strain gauge (142).Type: GrantFiled: January 30, 2007Date of Patent: February 17, 2009Assignee: The Cleveland Clinic FoundationInventors: Shuvo Roy, Aaron J Fleischman, Edward C. Benzel, Lisa Ferrara
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Patent number: 7284442Abstract: Systems and methods for in vivo sensing are provided. An excitation signal is produced, having a first frequency component and a second frequency component. The first frequency component is swept through a plurality of excitation frequencies within a frequency range of interest. A response signal is received from an in vivo sensor. The response signal includes a mix component having a frequency equal to one of a sum of a first excitation frequency associated with the first frequency component and a second excitation frequency associated with the second frequency component and a difference between the first and second excitation frequencies. The mix component is evaluated to determine a resonant frequency of the in vivo sensor.Type: GrantFiled: May 26, 2006Date of Patent: October 23, 2007Assignee: The Cleveland Clinic FoundationInventors: Aaron J. Fleischman, James R. Talman, Shuvo Roy
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Patent number: 7262068Abstract: A microneedle array module is disclosed comprising a multiplicity of microneedles affixed to and protruding outwardly from a front surface of a substrate to form the array, each microneedle of the array having a hollow section which extends through its center to an opening in the tip thereof. A method of fabricating the microneedle array module is also disclosed comprising the steps of: providing etch resistant mask layers to one and another opposite surfaces of a substrate to predetermined thicknesses; patterning the etch resistant mask layer of the one surface for outer dimensions of the microneedles of the array; patterning the etch resistant mask layer of the other surface for inner dimensions of the microneedles of the array; etching unmasked portions of the substrate from one and the other surfaces to first and second predetermined depths, respectively; and removing the mask layers from the one and the other surfaces.Type: GrantFiled: July 6, 2004Date of Patent: August 28, 2007Assignee: The Cleveland Clinic FoundationInventors: Shuvo Roy, Aaron J. Fleischman
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Publication number: 20070179409Abstract: An apparatus (10) that utilizes microelectromechanical systems (MEMS) technology to provide an in vivo assessment of loads on adjacent bones (24 and 26) comprises a body (34) for insertion between the adjacent bones. At least one sensor (42) is associated with the body (34). The sensor (42) generates an output signal in response to and indicative of a load being applied to the body (34) through the adjacent bones (24 and 26). A telemetric device (40) is operatively coupled with the sensor (42). The telemetric device (40) is operable to receive the output signal from the sensor (42) and to transmit an EMF signal dependent upon the output signal. According to various aspects of the invention, the sensor comprises a pressure sensor (42), a load cell (320), and/or at least one strain gauge (142).Type: ApplicationFiled: January 30, 2007Publication date: August 2, 2007Inventors: Shuvo Roy, Aaron Fleischman, Edward Benzel, Lisa Ferrara
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Publication number: 20070129623Abstract: An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner.compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: ApplicationFiled: January 30, 2007Publication date: June 7, 2007Inventors: Aaron Fleischman, Shuvo Roy, Hilel Lewis
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Publication number: 20070049845Abstract: Systems and methods for in vivo sensing are provided. An excitation signal is produced, having a first frequency component and a second frequency component. The first frequency component is swept through a plurality of excitation frequencies within a frequency range of interest.. A response signal is received from an in vivo sensor. The response signal includes a mix component having a frequency equal to one of a sum of a first excitation frequency associated with the first frequency component and a second excitation frequency associated with the second frequency component and a difference between the first and second excitation frequencies. The mix component is evaluated to determine a resonant frequency of the in vivo sensor.Type: ApplicationFiled: May 26, 2006Publication date: March 1, 2007Inventors: Aaron Fleischman, James Talman, Shuvo Roy
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Patent number: 7182736Abstract: An apparatus (10) that utilizes microelectromechanical systems (MEMS) technology to provide an in vivo assessment of loads on adjacent bones (24 and 26) comprises a body (34) for insertion between the adjacent bones. At least one sensor (42) is associated with the body (34). The sensor (42) generates an output signal in response to and indicative of a load being applied to the body (34) through the adjacent bones (24 and 26). A telemetric device (40) is operatively coupled with the sensor (42). The telemetric device (40) is operable to receive the output signal from the sensor (42) and to transmit an EMF signal dependent upon the output signal. According to various aspects of the invention, the sensor comprises a pressure sensor (42), a load cell (320), and/or at least one strain gauge (142).Type: GrantFiled: February 2, 2004Date of Patent: February 27, 2007Assignee: Cleveland Clinic FoundationInventors: Shuvo Roy, Aaron J. Fleischman, Edward C. Benzel, Lisa Ferrara
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Publication number: 20070038051Abstract: Methods and systems are provided for determining a characteristic of an in vivo sensor. A transmit field, operative to induce a response signal in an associated in vivo sensor, is generated at a transmitting component having an associated orientation. The response signal is received at a receiving component, having an associated orientation. The coupling between the transmitting component and the receiving component is measured. The associated orientation of at least one of the transmitting component and the receiving component is rotated as to reduce the measured coupling.Type: ApplicationFiled: May 26, 2006Publication date: February 15, 2007Inventors: James Talman, Shuvo Roy, Brian Sauer, Aaron Fleischman
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Patent number: 7169106Abstract: An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: GrantFiled: May 7, 2004Date of Patent: January 30, 2007Assignee: The Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy, Hilel Lewis
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Publication number: 20070020770Abstract: The present invention provides a MEMS-based integrated particle identification system having a substrate, a magnetic structure, and a bioferrograph. The substrate includes a topside portion, backside portion and a flow system. The flow system includes a flow channel for accepting the flow of a stream of particles to identified. The magnetic structure is in physical communication with the topside and backside portions of the substrate and has at least two pole pieces. A plurality of pole piece embodiments are provided for generating a magnetic field that acts on magnetically susceptible particles in the flow stream. The bioferrograph has at least one sensor for identifying the presence and quantity of magnetically susceptible particles. A plurality of sensor embodiments are also provided.Type: ApplicationFiled: September 27, 2006Publication date: January 25, 2007Inventors: Aaron Fleischman, Shuvo Roy, Jeff Chalmers, Maciej Zborowski
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Publication number: 20060229735Abstract: An implant includes a plurality of parallel layers spaced apart by a plurality of members. Each layer has a substantially uniform thickness between opposite surfaces and a plurality of openings that permit fluid flow through an interior of the implant defined by the layers. The surfaces of each layer includes an array of micro-structures. Each micro-structure has a substantially uniform shape and an average height of about 1 nm to about 20 ?m.Type: ApplicationFiled: October 14, 2005Publication date: October 12, 2006Inventors: Shuvo Roy, George Muschler, Aaron Fleischman, Alvaro Mata
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Publication number: 20060213836Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.Type: ApplicationFiled: May 19, 2006Publication date: September 28, 2006Inventors: William Fissell, H. Humes, Shuvo Roy, Aaron Fleischman
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Patent number: 7048856Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.Type: GrantFiled: September 11, 2003Date of Patent: May 23, 2006Assignees: Regents of the University of Michigan, Cleveland Clinic FoundationInventors: William H. Fissell, IV, H. David Humes, Shuvo Roy, Aaron Fleischman
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Patent number: 6994672Abstract: An apparatus (176) for measuring intraocular pressure (IOP) comprises an applanation tonometer (180) having a distal end that is movable toward the eye and a disposable module (188) positioned at the distal end. The module (188) includes a sensor carrier (192) and a sensor (10) connected to the sensor carrier. The sensor (10) comprises a contact surface (14) for making contact with a surface portion of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: GrantFiled: April 8, 2002Date of Patent: February 7, 2006Assignee: Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy
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Publication number: 20050079600Abstract: The present invention provides a MEMS-based integrated particle identification system having a substrate, a magnetic structure, and a bioferrograph. The substrate includes a topside portion, backside portion and a flow system. The flow system includes a flow channel for accepting the flow of a stream of particles to identified. The magnetic structure is in physical communication with the topside and backside portions of the substrate and has at least two pole pieces. A plurality of pole piece embodiments are provided for generating a magnetic field that acts on magnetically susceptible particles in the flow stream. The bioferrograph has at least one sensor for identifying the presence and quantity of magnetically susceptible particles. A plurality of sensor embodiments are also provided.Type: ApplicationFiled: July 24, 2003Publication date: April 14, 2005Inventors: Aaron Fleischman, Shuvo Roy, Jeff Chalmers, Maciej Zborowski
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Publication number: 20040243063Abstract: A microneedle array module is disclosed comprising a multiplicity of microneedles affixed to and protruding outwardly from a front surface of a substrate to form the array, each microneedle of the array having a hollow section which extends through its center to an opening in the tip thereof. A method of fabricating the microneedle array module is also disclosed comprising the steps of: providing etch resistant mask layers to one and another opposite surfaces of a substrate to predetermined thicknesses; patterning the etch resistant mask layer of the one surface for outer dimensions of the microneedles of the array; patterning the etch resistant mask layer of the other surface for inner dimensions of the microneedles of the array; etching unmasked portions of the substrate from one and the other surfaces to first and second predetermined depths, respectively; and removing the mask layers from the one and the other surfaces.Type: ApplicationFiled: July 6, 2004Publication date: December 2, 2004Applicant: The Cleveland Clinic FoundationInventors: Shuvo Roy, Aaron J. Fleischman
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Publication number: 20040207808Abstract: An apparatus (180) for measuring intraocular pressure (IOP) comprises a contact lens (40) including an inner surface (42) contoured to a surface portion (34) of an eye (36) and a sensor (10) disposed in the contact lens. The sensor (10) comprises a contact surface (14) for making contact with the surface portion (34) of the eye (36). The contact surface (14) includes an outer non-compliant region (16) and an inner compliant region (18) fabricated as an impedance element that varies in impedance as the inner compliant region changes shape. The sensor (10) further comprises a region of conductive material (38) electrically coupled to the impedance element of the compliant region (18) and responsive to an external signal for energizing the impedance element so that the IOP may be determined.Type: ApplicationFiled: May 7, 2004Publication date: October 21, 2004Applicant: The Cleveland Clinic FoundationInventors: Aaron J. Fleischman, Shuvo Roy, Hilel Lewis
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Publication number: 20040186396Abstract: An apparatus (10) that utilizes microelectromechanical systems (MEMS) technology to provide an in vivo assessment of loads on adjacent bones (24 and 26) comprises a body (34) for insertion between the adjacent bones. At least one sensor (42) is associated with the body (34). The sensor (42) generates an output signal in response to and indicative of a load being applied to the body (34) through the adjacent bones (24 and 26). A telemetric device (40) is operatively coupled with the sensor (42). The telemetric device (40) is operable to receive the output signal from the sensor (42) and to transmit an EMF signal dependent upon the output signal. According to various aspects of the invention, the sensor comprises a pressure sensor (42), a load cell (320), and/or at least one strain gauge (142).Type: ApplicationFiled: February 2, 2004Publication date: September 23, 2004Applicant: The Cleveland Clinic FoundationInventors: Shuvo Roy, Aaron J. Fleischman, Edward C. Benzel, Lisa Ferrara
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Patent number: 6790372Abstract: A microneedle array module is disclosed comprising a multiplicity of microneedles affixed to and protruding outwardly from a front surface of a substrate to form the array, each microneedle of the array having a hollow section which extends through its center to an opening in the tip thereof. A method of fabricating the microneedle array module is also disclosed comprising the steps of: providing etch resistant mask layers to one and another opposite surfaces of a substrate to predetermined thicknesses; patterning the etch resistant mask layer of the one surface for outer dimensions of the microneedles of the array; patterning the etch resistant mask layer of the other surface for inner dimensions of the microneedles of the array; etching unmasked portions of the substrate from one and the other surfaces to first and second predetermined depths, respectively; and removing the mask layers from the one and the other surfaces.Type: GrantFiled: June 5, 2002Date of Patent: September 14, 2004Assignee: Cleveland Clinic FoundationInventors: Shuvo Roy, Aaron J. Fleischman