Patents by Inventor Shuwen Liu
Shuwen Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11820894Abstract: A resin composition includes 100 parts by weight of a prepolymer and 100 parts by weight to 250 parts by weight of a spherical silica prepared by vaporized metal combustion, wherein: the prepolymer is prepared by subjecting a reaction mixture to a prepolymerization reaction; the reaction mixture includes a maleimide resin, an amino-modified silicone and cyclohexanone, and relative to a total of 100 parts by weight of the maleimide resin, the amino-modified silicone and the cyclohexanone, the reaction mixture includes 60 parts by weight to 80 parts by weight of the maleimide resin, 15 parts by weight to 30 parts by weight of the amino-modified silicone and 2 parts by weight to 15 parts by weight of the cyclohexanone; the reaction mixture does not include m-aminophenol or p-aminophenol; and the amino-modified silicone has an amino equivalent of 750 g/mol to 2500 g/mol.Type: GrantFiled: November 10, 2021Date of Patent: November 21, 2023Assignee: ELITE ELECTRONIC MATERIAL (ZHONGSHAN) CO., LTD.Inventors: Teng Xu, Zhilong Hu, Xiangnan Li, Shuwen Liu, Cheng Li
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Publication number: 20230099943Abstract: A resin composition includes 100 parts by weight of a prepolymer and 100 parts by weight to 250 parts by weight of a spherical silica prepared by vaporized metal combustion, wherein: the prepolymer is prepared by subjecting a reaction mixture to a prepolymerization reaction; the reaction mixture includes a maleimide resin, an amino-modified silicone and cyclohexanone, and relative to a total of 100 parts by weight of the maleimide resin, the amino-modified silicone and the cyclohexanone, the reaction mixture includes 60 parts by weight to 80 parts by weight of the maleimide resin, 15 parts by weight to 30 parts by weight of the amino-modified silicone and 2 parts by weight to 15 parts by weight of the cyclohexanone; the reaction mixture does not include m-aminophenol or p-aminophenol; and the amino-modified silicone has an amino equivalent of 750 g/mol to 2500 g/mol.Type: ApplicationFiled: November 10, 2021Publication date: March 30, 2023Inventors: Teng XU, Zhilong HU, Xiangnan LI, Shuwen LIU, Cheng LI
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Patent number: 11597958Abstract: The invention relates to a plasmid, a DNA assembly method and its application recombinant strain. The plasmid has single adjacent Type IIP and Type IIS RE recognition sites. The plasmid combines the properties of Type IIP and Type IIS REs to achieve recursive cycling, SCAR-free and repeat sequence assembly.Type: GrantFiled: December 23, 2019Date of Patent: March 7, 2023Assignee: NANJING ZHONGKEYOUZI INSTITUTE OF BIOTECHNOLOGY CO., LTDInventors: Shuwen Liu, Tingyi Wen, Yun Zhang, Aihua Deng
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Patent number: 11518882Abstract: A resin composition includes the following components or a prepolymerized product thereof. (A) 100 parts by weight of a prepolymer and (B) 5 parts by weight to 30 parts by weight of a diallyl bisphenol resin, wherein the prepolymer is prepared by subjecting a reaction mixture to a prepolymerization reaction, the reaction mixture includes a maleimide resin, an amino-modified silicone and cyclohexanone, and relative to a total of 100 parts by weight of the maleimide resin, the amino-modified silicone and the cyclohexanone, the reaction mixture includes 60 parts by weight to 80 parts by weight of the maleimide resin, 15 parts by weight to 30 parts by weight of the amino-modified silicone and 2 parts by weight to 15 parts by weight of the cyclohexanone; the reaction mixture does not include m-aminophenol or p-aminophenol; and the amino-modified silicone has an amino equivalent of 750 g/mol to 2500 g/mol.Type: GrantFiled: February 14, 2022Date of Patent: December 6, 2022Assignee: ELITE ELECTRONIC MATERIAL (ZHONGSHAN) CO., LTD.Inventors: Teng Xu, Zhilong Hu, Shuwen Liu, Cheng Li, Yuhui Liu
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Patent number: 11492616Abstract: The present invention discloses a method for modifying an amino acid attenuator, a class of amino acid attenuator mutants, engineered bacteria created on the basis of the amino acid attenuator mutants, and use of the engineered bacteria. The present invention protects a method for relieving the attenuation regulation of an amino acid operon gene, which is modification of the amino acid operon gene by: removing a gene coding for a leader peptide and an anterior reverse complementary palindromic sequence in the terminator stem-loop structure, and maintaining a posterior reverse complementary palindromic sequence in the terminator. The amino acid operon particularly can be histidine operon, tryptophan operon, phenylalanine operon, alanine operon, threonine operon and etc. The present invention can be used for the production of amino acids and derivatives thereof in fermentation by bacteria, providing a novel method for improving the production of amino acids in fermentation.Type: GrantFiled: October 24, 2017Date of Patent: November 8, 2022Assignee: Institute of Microbiology, Chinese Academy of SciencesInventors: Tingyi Wen, Shuwen Liu, Yun Zhang, Xiuling Shang, Haihan Xiao
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Patent number: 11472815Abstract: Provided are 1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives having a structure represented by Formula I, a preparation method therefor and uses thereof: wherein R1 is any one of H, OH, and OCH3, R2 is any one of H, NO2, CH3, CF3, SO2CH3, COOCH3, or CONHCH3, R3 is any one of H, NO2, OCH3, or CF3, R4 is selected from H, CF3, or Cl, R5 is any one of H, Cl, CF3, or NHCH3, and R6 is any one of OCF3, CF3, or CN; V is either C or N, W is either CH or N, X is a C atom, Y is either CH or N, and Z is either CH or S. This compound can be used in preparation of anti-inflammatory adjuvants, TLR1 or TLR2 agonists, and anti-tumor agents and for regulating the activity activation level of TLR1 and TLR2 alkaline phosphatases in vitro and in vivo.Type: GrantFiled: April 9, 2018Date of Patent: October 18, 2022Assignee: SOUTHERN MEDICAL UNIVERSITYInventors: Kui Cheng, Shuwen Liu, Gengzhen Zhu
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Patent number: 11060080Abstract: A method for fermentation-production of a pentanediamine, comprising: culturing a cell expressing a lysine decarboxylase to obtain a whole cell fermentation broth comprising a pentanediamine; and extracting the pentanediamine from the whole cell fermentation broth, and striping the whole cell fermentation broth of carbon dioxide contained therein before adding a strong base. The method greatly increases a production volume of the pentanediamine.Type: GrantFiled: May 16, 2017Date of Patent: July 13, 2021Assignee: HEILONGJIANG EPPEN NEW MATERIALS CO., LTD.Inventors: Jiyin Ma, Tingyi Wen, Shuwen Liu, Yong Liang, Daihuan Li, Yun Zhang, Xiuling Shang, Chunguang Zhao, Xiaowei Guo, Gang Meng
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Publication number: 20210017189Abstract: Provided are 1,4-diphenyl-1H-imidazole and 2,4-diphenylthiazole derivatives having a structure represented by Formula I, a preparation method therefor and uses thereof: wherein R1 is any one of H, OH, and OCH3, R2 is any one of H, NO2, CH3, CF3, SO2CH3, COOCH3, or CONHCH3, R3 is any one of H, NO2, OCH3, or CF3, R4 is selected from H, CF3, or Cl, R5 is any one of H, Cl, CF3, or NHCH3, and R6 is any one of OCF3, CF3, or CN; V is either C or N, W is either CH or N, X is a C atom, Y is either CH or N, and Z is either CH or S. This compound can be used in preparation of anti-inflammatory adjuvants, TLR1 or TLR2 agonists, and anti-tumor agents and for regulating the activity activation level of TLR1 and TLR2 alkaline phosphatases in vitro and in vivo.Type: ApplicationFiled: April 9, 2018Publication date: January 21, 2021Applicant: SOUTHERN MEDICAL UNIVERSITYInventors: Kui CHENG, Shuwen LIU, Gengzhen ZHU
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Publication number: 20200347419Abstract: A recombinant bacterium for producing L-lysine, a construction method thereof, and a method for producing L-lysine by using the recombinant bacterium. The recombinant bacterium has increased expression and/or activity of asparaginase compared to a starting bacterium.Type: ApplicationFiled: May 22, 2018Publication date: November 5, 2020Inventors: Tingyi WEN, Chen ZHANG, Xiuling SHANG, Xin CHAI, Yun ZHANG, Shuwen LIU, Guoqiang WANG, Zhongcai LI
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Patent number: 10759757Abstract: A method of preparing a crystalline contrast agent for magnetic resonance imaging from a zwitterionic carboxylic pyridyl ligand includes mixing metal ion and the pyridyl ligand and obtaining crystals therefrom. The crystalline contrast agent includes a manganese-organic or gadolinium-organic 3D framework. The crystalline contrast agent is employed in a kit and a pharmaceutically acceptable composition. The method allows for preparing crystalline contrast agents with superior properties with easily available starting materials and with an economic and efficient process. The method allows for preparing crystalline contrast agents with exceptional water-stability and water-solubility, which exhibit high longitudinal relaxivities and with excellent stabilities under physiological conditions and low cytotoxicity. Further provided is a method for in vivo imaging of a subject, in particular a human, comprising administering the crystalline contrast agent to the subject.Type: GrantFiled: September 21, 2016Date of Patent: September 1, 2020Assignees: Macau University of Science and Technology, Southern Medical UniversityInventors: Jinxiang Chen, Jianxin Pang, Shuwen Liu, Li-Ping Bai, Zhi-Hong Jiang
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Publication number: 20200208188Abstract: The invention relates to a plasmid, a DNA assembly method and its application recombinant strain. The plasmid has single adjacent Type IIP and Type IIS RE recognition sites. The plasmid combines the properties of Type IIP and Type IIS REs to achieve recursive cycling, SCAR-free and repeat sequence assembly.Type: ApplicationFiled: December 23, 2019Publication date: July 2, 2020Inventors: Shuwen LIU, Tingyi WEN, Yun ZHANG, Aihua DENG
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Publication number: 20190338282Abstract: The present invention discloses a method for modifying an amino acid attenuator, a class of amino acid attenuator mutants, engineered bacteria created on the basis of the amino acid attenuator mutants, and use of the engineered bacteria. The present invention protects a method for relieving the attenuation regulation of an amino acid operon gene, which is modification of the amino acid operon gene by: removing a gene coding for a leader peptide and an anterior reverse complementary palindromic sequence in the terminator stem-loop structure, and maintaining a posterior reverse complementary palindromic sequence in the terminator. The amino acid operon particularly can be histidine operon, tryptophan operon, phenylalanine operon, alanine operon, threonine operon and etc.Type: ApplicationFiled: October 24, 2017Publication date: November 7, 2019Inventors: Tingyi Wen, Shuwen Liu, Yun Zhang, Xiuling Shang, Haihan Xiao
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Publication number: 20190322995Abstract: A method for fermentation-production of a pentanediamine, comprising: culturing a cell expressing a lysine decarboxylase to obtain a whole cell fermentation broth comprising a pentanediamine; and extracting the pentanediamine from the whole cell fermentation broth, and striping the whole cell fermentation broth of carbon dioxide contained therein before adding a strong base. The method greatly increases a production volume of the pentanediamine.Type: ApplicationFiled: May 16, 2017Publication date: October 24, 2019Applicant: Ningxia EPPEN Biotech Co., LtdInventors: Jiyin MA, Tingyi WEN, Shuwen LIU, Yong LIANG, Daihuan LI, Yun ZHANG, Xiuling SHANG, Chunguang ZHAO, Xiaowei GUO, Gang MENG
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Patent number: 10017798Abstract: The present invention discloses an E. coli engineering bacteria producing 1,5pentanediamine through a whole cell catalysis and its application. The engineering bacteria according to the present invention, is Escherichia coli (E. coli) strain B or its derivative strains with the overexpression of a lysine decarboxylase gene and a proper expression of a lysinecadaverine antiporter gene cadB.Type: GrantFiled: June 25, 2015Date of Patent: July 10, 2018Assignee: NINGXIA EPPEN BIOTECH CO., LTDInventors: Tingyi Wen, Shuwen Liu, Yong Liang, Xiuling Shang, Qian Liu, Jifu Wen, Yun Zhang
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Publication number: 20180078660Abstract: A method of preparing a crystalline contrast agent for magnetic resonance imaging from a zwitterionic carboxylic pyridyl ligand includes mixing metal ion and the pyridyl ligand and obtaining crystals therefrom. The crystalline contrast agent includes a manganese-organic or gadolinium-organic 3D framework. The crystalline contrast agent is employed in a kit and a pharmaceutically acceptable composition. The method allows for preparing crystalline contrast agents with superior properties with easily available starting materials and with an economic and efficient process. The method allows for preparing crystalline contrast agents with exceptional water-stability and water-solubility, which exhibit high longitudinal relaxivities and with excellent stabilities under physiological conditions and low cytotoxicity. Further provided is a method for in vivo imaging of a subject, in particular a human, comprising administering the crystalline contrast agent to the subject.Type: ApplicationFiled: September 21, 2016Publication date: March 22, 2018Inventors: Jinxiang Chen, Jianxin Pang, Shuwen Liu, Li-Ping Bai, Zhi-Hong Jiang
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Patent number: 9796991Abstract: The present invention relates to recombinant bacteria producing L-amino acid, in which the recombinant bacteria has reduced expression of the glucose-6-phosphate isomerase gene pgi and improved expression of the glucose-6-phosphate dehydrogenase gene -opcA than the starting bacteria, where the starting bacterium is a bacterial strain that can accumulate target amino acid(s) and preferably, the amino acid is L-histidine.Type: GrantFiled: February 4, 2015Date of Patent: October 24, 2017Assignee: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Tingyi Wen, Xiuling Shang, Yun Zhang, Shuwen Liu, Yong Liang, Yu Zhang
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Publication number: 20170226544Abstract: The present invention discloses an E. coli engineering bacteria producing 1,5-pentanediamine through a whole cell catalysis and its application. The engineering bacteria according to the present invention, is Escherichia coli (E. coli) strain B or its derivative strains with the overexpression of a lysine decarboxylase gene and a proper expression of a lysine-cadaverine antiporter gene cadB. The engineering bacteria according to the present invention is the engineering bacteria producing 1,5-pentanediamine through the whole cell catalysis constructed from Escherichia coli B derivative strains, which has an overexpression of a lysine decarboxylase gene cadA and a proper expression of the lysine-cadaverine antiporter gene cadB.Type: ApplicationFiled: June 25, 2015Publication date: August 10, 2017Inventors: TINGYI WEN, SHUWEN LIU, YONG LIANG, XIULING SHANG, QIAN LIU, JIFU WEN, YUN ZHANG
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Publication number: 20160326556Abstract: The present application discloses recombinant bacteria producing L-amino acid(s) its construction method and the method of producing L-amino acid(s). The recombinant bacteria producing L-amino acid(s) according to the present invention has reduced expression of the glucose-6-phosphate isomerase Pgi and improved expression of the glucose-6-phosphate dehydrogenase Zwf-OpcA than the starting bacteria, wherein: said starting bacterium is a bacterial strain which can accumulate target amino acid(s). During fermenting and culturing the recombinant bacteria according to the present invention, it is observed that the effect of improving yield can be additive and the yield of L-amino acid(s) is improved obviously. The strategy of combinational modification according to the present invention develops a new method of improving the yield of L-amino acid(s) and hence it can be applied to produce L-amino acid(s) through bacterialfermentation.Type: ApplicationFiled: February 4, 2015Publication date: November 10, 2016Applicant: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Tingyi Wen, Xiuling Shang, Yun Zhang, Shuwen Liu, Yong Liang, Yu Zhang
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Publication number: 20160002684Abstract: A method for producing L-lysine by fermentation comprises the steps of modifying an aconitase gene and/or regulatory element thereof in a chromosome of a bacterium so that the activity and/or the expression amount of the aconitase of the bacterium are reduced but not eliminated; and producing L-lysine by the fermentation of the modified bacterium. In addition, also provided are methods and uses derived from the method as well as bacteria used in these methods and uses.Type: ApplicationFiled: January 7, 2014Publication date: January 7, 2016Inventors: Jiyin MA, Tingyi WEN, Jinlong CHEN, Yong LIANG, Shuwen LIU, Aiying WEI, Lipeng YANG, Rui REN, Gang MENG, Chunguang ZHAO, Yun ZHANG, Xiuling SHANG, Xiaowei GUO
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Patent number: 8906927Abstract: The present invention provides a series of penta-substituted tetrahydropyrimidines with aggregation-induced emission (AIE) characteristics and preparation method and use thereof. The AIE penta-substituted tetrahydropyrimidines have structures shown as formula (I). R1 is selected from a group consisting of linear or branched alkyls and substituted alkyls. R2 and R4 is respectively selected from a group consisting of linear or branched alkyls, substituted alkyls, cycloalkyls, substituted cycloalkyls, aryls, substituted aryls, polycyclic aryls, substituted polycyclic aryls, heterocyclyls, substituted heterocyclyls, aromatic heterocyclyls and substituted aromatic heterocyclyls. R3 is selected from a group consisting of aryls, substituted aryls, polycyclic aryls, substituted polycyclic aryls, aromatic heterocyclyls and substituted aromatic heterocyclyls. The penta-substituted tetrahydropyrimidines can be prepared by multi-component reactions (MCR).Type: GrantFiled: December 24, 2011Date of Patent: December 9, 2014Assignee: Southern Medical UniversityInventors: Qiuhua Zhu, Shuwen Liu