Abstract: An object of the present invention is to provide a method for producing a microcapsule formulation using a biodegradable polymer, the method being capable of avoiding direct contact of a peptidic physiologically active substance with an organic solvent layer, and achieving a high encapsulation efficiency of the peptidic physiologically active substance.

Abstract: [Object] An object of the present invention is to provide a method for producing a microcapsule formulation using a biodegradable polymer, the method being capable of avoiding direct contact of a peptidic physiologically active substance with an organic solvent layer, and achieving a high encapsulation efficiency of the peptidic physiologically active substance.

Abstract: A support for enzyme immobilization is described, which is for immobilizing enzymes of various molecular sizes and also for, due to the modification of the surface silanol groups of porous silica particles, for immobilizing various kinds of enzymes, and enables the design of an immobilized enzyme, which exhibits an activity equivalent to that of the corresponding non-immobilized enzyme and withstands repeated use. A method for producing the support is also described. The support includes porous silica particles having an interparticle void structure therein, characterized in that the porous silica particles have a specific average particle size, a specific surface area, a specific pore volume, a specific pore size distribution and a specific porosity and have a substituent containing an organic group or an amino group on the surface thereof. An immobilized protein obtained by immobilizing a protein on the above support is also described.

Abstract: A method for culturing cells or microorganisms by dissolving oxygen or carbon dioxide in a culture solution containing a nutrient including: supplying gas containing oxygen or carbon dioxide into inside of a glass porous body being configured to have cylindrical shape and a large number of uniformly fine pores in the outer surface and being configured to seal the end of the glass porous body; generating bubbles that have a 50% diameter of 200 ?m or less in a volume-based particle size distribution from the outer surface of the porous body by using gas containing oxygen or carbon dioxide that is supplied from an unsealed end of the glass porous body; suppressing aggregation of the bubbles by at least one of a cell-protecting agent for protecting the cells and a protein hydrolysate included in the culture solution; and dissolving oxygen or carbon dioxide in the culture solution.

Abstract: A method for evaluating the powder dispersibility including dispersing a powder allowed to stand inside a closed container by mechanical vibration applied quantitatively to the powder; collecting the dispersed powder on a quartz crystal element or a piezo element; and measuring the mass of the collected powder using a quartz crystal microbalance or a piezo element mass meter to thereby measure the airborne powder concentration in air inside the closed container; a method for evaluating airborne powder concentration at work place using the method for evaluating the powder dispersibility; and a method for designing a powder containment facility using the method for evaluating airborne powder concentration.

Abstract: A method for evaluating the powder dispersibility including dispersing a powder allowed to stand inside a closed container by mechanical vibration applied quantitatively to the powder; collecting the dispersed powder on a quartz crystal element or a piezo element; and measuring the mass of the collected powder using a quartz crystal microbalance or a piezo element mass meter to thereby measure the airborne powder concentration in air inside the closed container; a method for evaluating airborne powder concentration at work place using the method for evaluating the powder dispersibility; and a method for designing a powder containment facility using the method for evaluating airborne powder concentration.