Patents by Inventor Shyamal D. Desai

Shyamal D. Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240183864
    Abstract: This invention is directed to compositions and methods for detecting proteinopathies.
    Type: Application
    Filed: March 29, 2021
    Publication date: June 6, 2024
    Inventor: Shyamal D. Desai
  • Publication number: 20210320969
    Abstract: This invention is directed to compositions and methods for detecting proteinopathies.
    Type: Application
    Filed: March 29, 2021
    Publication date: October 14, 2021
    Inventor: Shyamal D. Desai
  • Patent number: 10962553
    Abstract: This invention is directed to compositions and methods for detecting proteinopathies.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: March 30, 2021
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Shyamal D. Desai
  • Publication number: 20180120334
    Abstract: This invention is directed to compositions and methods for detecting proteinopathies.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 3, 2018
    Inventor: Shyamal D. Desai
  • Publication number: 20170196871
    Abstract: ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T. Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 13, 2017
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Shyamal D. Desai
  • Patent number: 9599626
    Abstract: ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 21, 2017
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Shyamal D. Desai
  • Publication number: 20160216279
    Abstract: ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients.
    Type: Application
    Filed: November 29, 2012
    Publication date: July 28, 2016
    Inventor: Shyamal D. Desai
  • Publication number: 20140148496
    Abstract: ATM kinase is shown to regulate proteasome-mediated protein turnover through suppression of the expression of the ubiquitin-like protein ISG15 (Interferon Stimulated Gene 15). Silencing of the ISG15 pathway restored both the ubiquitin and autophagy pathways, and the UV-mediated degradation of their substrates in A-T cells. The ATM kinase negatively regulates the ISG15 pathway, and the constitutively elevated ISG15 pathway induces proteinopathy in A-T cells, and in A-T patients. These findings indicate that proteasome-mediated protein degradation is impaired in A-T cells due to elevated expression of the ISG15 conjugation pathway, which contributes to progressive neurodegeneration in A-T patients. The ISG15 pathway is a new target for both detection and treatment of A-T Inhibitors if ISG15 expression can be used to inhibit or attenuate neurodegeneration in A-T patients.
    Type: Application
    Filed: November 29, 2012
    Publication date: May 29, 2014
    Inventor: Shyamal D. Desai