Patents by Inventor Siegfried Benjamin Christensen, IV

Siegfried Benjamin Christensen, IV has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds as diacylglycerol acyltransferase inhibitors
    Patent number: 9242929
    Abstract: This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: January 26, 2016
    Assignee: GlaxoSmithKline Intellectual Property (No.2) Limited
    Inventors: Siegfried Benjamin Christensen, IV, Rowena Christensen, Donghui Qin, Hemant Joshi, Raghuram S. Tangirala
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20130045962
    Abstract: The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives. Specifically, the invention is directed to compounds of formula (I): wherein R1, R2 and R3 are defined below and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.
    Type: Application
    Filed: November 6, 2008
    Publication date: February 21, 2013
    Inventors: Donghui Qin, Beth Norton, Xiangmin Liao, Andrew Nicholson Knox, Jinhwa Lee, Yuhong Fang, Jason Christopher Dreabit, Siegfried Benjamin Christensen, IV, Andrew B. Benowitz, Kelly M. Aubart
  • BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISTS
    Publication number: 20120083489
    Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.
    Type: Application
    Filed: June 2, 2010
    Publication date: April 5, 2012
    Inventors: Siegfried Benjamin Christensen IV, Donghui Qin, Shenglin Chen, Xing Huang, Di Li, Fei Li, Lei Li, Xiaojuan Lin, Shi Lu, Zhen Lu, Maoyun Lv, Chuanning Wang, Chengde Wu, Mei Xiao, Haiyu Yu, Weina Zhang, Zhiliu Zhang
  • BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS
    Publication number: 20120077794
    Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.
    Type: Application
    Filed: June 2, 2010
    Publication date: March 29, 2012
    Applicant: GLAXSMITHKLINE LLC
    Inventors: Siegfried Benjamin Christensen, IV, Donghui Qin, Shenglin Chen, Xing Huang, Di Li, Fei Li, Xiaojuan Lin, Shi Lu, Maoyun Lv, Chengde Wu, Weiliang Xu, Gang Yan, Jianxing Yuan, Weina Zhang, Zhiliu Zhang
  • BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS
    Publication number: 20120077795
    Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.
    Type: Application
    Filed: June 2, 2010
    Publication date: March 29, 2012
    Applicant: GLAXSMITHKLINE LLC
    Inventors: Siegfried Benjamin Christensen IV, Donghui Qin, Shi Lu, Shuai Wei, Nianyong Yang, Zhiliu Zhang
  • BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS
    Publication number: 20120071459
    Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and diabetes.
    Type: Application
    Filed: June 2, 2010
    Publication date: March 22, 2012
    Inventors: Siegfried Benjamin Christensen, IV, Donghui Qin, Shuhul Chen, Shi Lu
  • Pyrazolo[3,4-b]pyridine compound, and its use as a PDE4 inhibitor
    Patent number: 7709497
    Abstract: The invention provides 4-{[1-(aminocarbonyl)-4-piperidinyl]amino}-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, which is the compound of formula (I): or a salt thereof.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: May 4, 2010
    Assignee: Glaxo Group Limited
    Inventors: Siegfried Benjamin Christensen, IV, Caroline Mary Cook, Christopher David Edlin, Martin Redpath Johnson, Paul Spencer Jones, Mika Kristian Lindvall, Amyn Pyarali Sayani, Naimisha Trivedi, Lionel Trottet
  • Peptide deformylase inhibitors
    Patent number: 7332485
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: February 19, 2008
    Assignee: SmithKline Beecham Corp
    Inventors: Kelly M. Aubart, Siegfried Benjamin Christensen, IV, Chaya Duraiswami, Joseph M. Karpinski
  • Anti-inflammatory and anti-asthma treatment with reduced side effects
    Patent number: 6143782
    Abstract: This invention relates to a method for selecting PDE IV inhibitors which have a salutory therapeutic index, and to compounds having these properties.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: November 7, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Mary S. Barnette, Theodore J. Torphy, Siegfried Benjamin Christensen, IV
  • Cannabinoid receptor modulators
    Patent number: 6100259
    Abstract: Novel pyrazole derivatives are provided which are cannabinoid receptor modulators.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: August 8, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jia-Ning Xiang, John Duncan Elliott, Steven Todd Atkinson, Siegfried Benjamin Christensen, IV
  • Compounds and methods for treating PDE IV-related diseases
    Patent number: 5998428
    Abstract: This invention relates to a method for selecting PDE IV inhibitors which have a salutory therapeutic index, and to compounds having these properties.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: December 7, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Mary S. Barnette, Theodore J. Torphy, Siegfried Benjamin Christensen, IV
  • Cannabinoid receptor agonists
    Patent number: 5948777
    Abstract: Novel pyrazole derivatives are provided which are cannabinoid receptor agonists.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: September 7, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Paul Elliot Bender, Siegfried Benjamin Christensen, IV
  • Compounds useful for treating allergic or inflammatory diseases
    Patent number: 5811455
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: September 22, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried Benjamin Christensen, IV, Paul Elliot Bender, Cornelia Jutta Forster
  • Compounds, compositions and treatment of allergies and inflammation therewith
    Patent number: 5780667
    Abstract: Novel cyclohexane derivatives of Formula (I) ##STR1## are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production; they are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.
    Type: Grant
    Filed: May 27, 1996
    Date of Patent: July 14, 1998
    Assignee: SmithKline Beecham Corporation
    Inventor: Siegfried Benjamin Christensen, IV
  • Compounds useful for treating allergic and inflammatory diseases
    Patent number: 5643946
    Abstract: Compounds of the formula ##STR1## wherein the substituents are as defined herein, are disclosed. Pharmaceutical compositions and methods of treating allergic and inflammatory diseases are also taught.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: July 1, 1997
    Assignee: SmithKline Beecham Corporation
    Inventor: Siegfried Benjamin Christensen, IV