Patents by Inventor Siegfried Raddatz

Siegfried Raddatz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aryl sulphonamides and analogues
    Patent number: 6469054
    Abstract: The present invention relates to novel arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: October 22, 2002
    Assignee: Bayer Aktiengesellshaft
    Inventors: Joachim Mittendorf, Jürgen Dressel, Michael Matzke, Jörg Keldenich, Frank Mauler, Jean-Marie-Victor de Vry, Jürgen Franz, Peter Spreyer, Verena Vöhringer, Joachim Schumacher, Michael-Harold Rock, Ervin Horvàth, Arno Friedl, Klaus-Helmut Mohrs, Siegfried Raddatz, Reinhard Jork
  • Arylsulfonamides and analogues
    Publication number: 20020072529
    Abstract: The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy and craniocerebral trauma.
    Type: Application
    Filed: June 11, 2001
    Publication date: June 13, 2002
    Inventors: Joachim Mittendorf, Jurgen Dressel, Michael Matzke, Jorg Keldenich, Klaus-Helmut Mohrs, Siegfried Raddatz, Jurgen Franz, Peter Spreyer, Verena Vohringer, Joachim Schuhmacher, Michael-Harold Rock, Ervin Horvath, Arno Friedl, Frank Mauler, Jean Marie Viktor de Vry, Reinhard Jork
  • Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases
    Patent number: 6262112
    Abstract: The present invention relates to new aryl ether sulphonamides and analogs, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy and craniocerebral trauma.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: July 17, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Joachim Mittendorf, Jürgen Dressel, Michael Matzke, Jörg Keldenich, Klaus-Helmut Mohrs, Siegfried Raddatz, Jürgen Franz, Peter Spreyer, Verena Vöhringer, Joachim Schuhmacher, Michael-Harold Rock, Ervin Horváth, Arno Friedl, Frank Mauler, Jean Marie Viktor de Vry, Reinhard Jork
  • Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments
    Patent number: 5776964
    Abstract: The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: July 7, 1998
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Muller, Klaus Mohrs, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Michael Matzke, Ulrich Niewohner, Siegfried Raddatz, Thomas Kramer, Matthias Muller-Gliemann, Hans-Peter Bellemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil
  • Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents
    Patent number: 5691337
    Abstract: Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: November 25, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Klaus-Helmut Mohrs, Siegfried Raddatz, Michael Matzke, Rudi Grutzmann, Martin Beuck, Stefan Wohlfeil, Hilmar Bischoff, Dirk Denzer
  • Oxy-phenyl-(phenyl)glycinolamides with heterocyclic substituents
    Patent number: 5646162
    Abstract: Oxy-phenyl-(phenyl)gycinolamides with heterocyclic substituents are prepared by reaction of the corresponding oxyphenylcarboxylic acids with heterocyclic substituents with phenylglycinol. The new substances are suitable as active compounds in medicaments, in particular in agents having an antiatherosclerotic action.
    Type: Grant
    Filed: December 1, 1995
    Date of Patent: July 8, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Muller, Richard Connell, Siegfried Goldmann, Klaus-Helmut Mohrs, Siegfried Raddatz, Michael Matzke, Rudi Grutzmann, Martin Beuck, Stefan Wohlfeil, Hilmar Bischoff, Dirk Denzer
  • Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives
    Patent number: 5597833
    Abstract: Substituted quinol-2-yl-methoxy-phenylacetic acid derivatives are prepared by reacting correspondingly substituted phenols with quinolylmethyl halides or by reacting unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The substituted quinol-2-yl-methoxy-phenylacetic acid derivatives may be employed as active substances in medicaments.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: January 28, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Matzke, Klaus-Helmut Mohrs, Siegfried Raddatz, Romanis Fruchtmann, Reiner M uller-Peddinghaus, Armin Hatzelmann
  • Substituted (2-oxo-1-benzimidazolinyl)-peperidines, process for their preparation, and use as anti-retroviral agents
    Patent number: 5571921
    Abstract: The present invention relates to substituted (2-oxo-1-benzimidazolinyl)-piperidines of the general formula (I) ##STR1## in which the substituents have the meaning indicated in the description, to processes for their preparation and to their use as antiretroviral agents.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 5, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Bender, Dieter H abich, Siegfried Raddatz, Wolfgang R oben, Hanno Wild, Jutta Hansen, Arnold Paessens
  • Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments
    Patent number: 5521206
    Abstract: The invention relates to phenylacetic acid derivatives of the formula ##STR1## which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.
    Type: Grant
    Filed: April 15, 1994
    Date of Patent: May 28, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Muller, Klaus Mohrs, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Michael Matzke, Ulrich Niewohner, Siegfried Raddatz, Thomas Kramer, Matthias Muller-Gliemann, Hans-Peter Belleman, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil
  • Use of substituted chromans, some of which are known, as medicaments, new active compounds and processes for their preparation
    Patent number: 5492918
    Abstract: The present invention relates to the use of substituted chromans of the general formula (I) ##STR1## in which the substituents have the meaning indicated in the description, for the production of medicaments, in particular as HIV protease-inhibiting agents, new active compounds and processes for their preparation.
    Type: Grant
    Filed: June 1, 1994
    Date of Patent: February 20, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hanno Wild, Wolfgang Bender, Dieter Habich, Hans-Georg Heine, Siegfried Raddatz, Wolfgang Roben, Jutta Hansen, Arnold Paessens
  • Enantiomerically pure intermediates for (quinolin-2-yl-methoxy) phenylacetic acids
    Patent number: 5473076
    Abstract: (Quinolin-2-yl-methoxy)phenylacetic acids are known as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism. Enantiomerically pure (quinolin-2-yl-methoxy)phenylacetic acids can be prepared in a simple manner and in high purity and yield by diastereoselective alkylation of corresponding (quinolin-2-yl-methoxy)phenylacetic acid menthyl esters and subsequent specific removal of the ester radical with acids.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: December 5, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Decker, Klaus-Helmut Mohrs, Siegfried Raddatz
  • Quinolin-2-yl-methoxybenzylhydroxyureas
    Patent number: 5399698
    Abstract: The novel quinolin-2-yl-methoxybenzylhydroxyureas can be prepared by reaction of appropriate ketones with hydroxylamine and reduction of the ketoximes and subsequent reaction with isocyanates. The new substances can be employed as active substances in medicaments.
    Type: Grant
    Filed: February 17, 1993
    Date of Patent: March 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Matzke, Klaus-Helmut Mohrs, Siegfried Raddatz, Romanis Fruchtmann, Armin Hatzelmann, Christian Kohlsdorfer, Reiner Muller-Peddinghaus, Pia Theisen-Popp
  • Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and -cyanamides, processes for their preparation and their use in medicaments
    Patent number: 5391747
    Abstract: A (quinolin-2-yl-methoxy) phenylacyl-sulphonamide or -cyanamide of the formula ##STR1## and physiologically acceptable salts thereof. The (quinolin-2-yl-methoxy)phenylacylsulphonamide or -cyanamide is useful as an active compound in medicaments, particularly as a lipoxygenase inhibitor.
    Type: Grant
    Filed: September 23, 1991
    Date of Patent: February 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Raddatz, Klaus-Helmut Mohrs, Romanis Fruchtmann, Christian Kohlsdorfer, Pia Theisen-Popp, Reiner Muller-Peddinghaus
  • Quinolylmethoxyphenyl-acetamides
    Patent number: 5310744
    Abstract: Quinolylmethoxyphenyl-acetamides of the formula: ##STR1## in which A, B, D, E, G, L and M are hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl;R.sub.1 represents optionally substituted cycloalkyl; andR.sub.2 and R.sub.3 independently represent hydrogen, alkyl, benzyl, or optionally substituted cycloalkyl; or together represent piperidinyl, morpholino, or piperazinyl;show a high in vitro activity as leukotriene synthesis inhibitors and, therefore, are suitable for the treatment and prevention of inflammations.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: May 10, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Raddatz, Klaus-Helmut Mohrs, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Reiner Muller-Peddinghaus
  • Process for the preparation of enantiomerically pure substituted (quinolin-2-yl-methoxy)phenylacetic acids
    Patent number: 5306820
    Abstract: (Quinolin-2-yl-methoxy)phenylacetic acids are known as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.Enantiomerically pure (quinolin-2-yl-methoxy)phenylacetic acids can be prepared in a simple manner and in high purity and yield by diastereoselective alkylation of corresponding (quinolin-2-yl-methoxy)phenylacetic acid menthyl esters and subsequent specific removal of the ester radical with acids.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: April 26, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Decker, Klaus-Helmut Mohrs, Siegfried Raddatz
  • 2-substituted quinolines, and their use in medicaments
    Patent number: 5304563
    Abstract: The title compounds are prepared either by reacting the corresponding halogenomethylquinolines with substituted phenols, optionally subsequently alkylating these or hydrolysing esters to acids, or by reacting phenyl-substituted quinolinecarboxylic acid derivatives with sulphonamides. The new phenyl-substituted quinolines are utilizable as active substances in medicaments, in particular as lipoxygenase inhibitors.
    Type: Grant
    Filed: October 28, 1992
    Date of Patent: April 19, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Raddatz, Klaus-Helmut Mohrs, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Christian Kohlsdorfer, Reiner Muller-Peddinghaus, Pia Theisen-Popp
  • Substituted mandelic acid derivatives and their use in medicaments
    Patent number: 5292769
    Abstract: Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: March 8, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Mohrs, Siegfried Raddatz, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Christian Kohlsdorfer, Reiner Muller-Peddinghaus, Pia Theisen-Popp
  • Quinolylmethoxyphenylacetic acid acylamides and ureas
    Patent number: 5288733
    Abstract: Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The quinolylmethoxyphenylacetic acid acylamides or ureas can be used as active compounds in medicaments.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: February 22, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Raddatz, Klaus-Helmut Mohrs, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Reiner Muller-Peddinghaus
  • Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives
    Patent number: 5283252
    Abstract: Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of halogenoacetoacetic acid esters with quinolylmethoxyphenylacetic acid thioamides, which are obtainable from corresponding amides with Lawesson's reagent. The substances can be employed in medicaments as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: February 1, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Raddatz, Klaus-Helmut Mohrs, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Reiner Muller-Peddinghaus
  • Heterocyclically substituted quinolylmethoxy-phenylacetamides
    Patent number: 5266578
    Abstract: Heterocyclically substituted quinolylmethoxyphenylacetamides are prepared by amidation of corresponding carboxylic acids. The compounds can be used in medicaments, in particular those having lipoxygenase-inhibiting action.
    Type: Grant
    Filed: August 26, 1992
    Date of Patent: November 30, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Raddatz, Klaus-Helmut Mohrs, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Christian Kohlsdorfer, Reiner Muller-Peddinghaus, Pia Theisen-Popp