Patents by Inventor Sigmund A. Weitzman

Sigmund A. Weitzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tissue specific adenovirus vectors for breast cancer treatment
    Patent number: 6096718
    Abstract: Replication defective adenoviral vectors serve as vehicles for genes encoding products that kill cells in which the genes are transferred and activated. The novel vectors include tissue specific promoters, and are successful in targeting mammalian cancer cells, in particular human breast cancer cells, and causing tumors to regress.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: August 1, 2000
    Assignee: Gene Targeting Corp.
    Inventors: Sigmund Weitzman, Bayar Thimmapaya, Leonard Anderson
  • Human epithelial cell matrix and uses therefor
    Patent number: 5935853
    Abstract: A method of growing epithelial cells by contacting the cells with the extracellular matrix deposited or secreted by human MCF-10A mammary epithelial cells. The MCF-10A matrix stimulates cell attachment and hemidesmosome formation in epithelial cells contacted therewith. The invention also encompasses the isolated or purified MCF-10A matrix, compositions comprising the matrix, and shaped articles coated with the matrix.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: August 10, 1999
    Assignee: Northwestern University
    Inventors: Jonathan C. R. Jones, Stephanie Stahl, Sigmund A. Weitzman
  • Human epithelial cell matrix and uses therefor
    Patent number: 5770448
    Abstract: A method of growing epithelial cells by contacting the cells with the extracellular matrix deposited or secreted by human MCF-10A mammary epithelial cells. The MCF-10A matrix stimulates cell attachment and hemidesmosome formation in epithelial cells contacted therewith. The invention also encompasses the isolated or purified MCF-10A matrix, compositions comprising the matrix, and shaped articles coated with the matrix.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: June 23, 1998
    Assignee: Northwestern University
    Inventors: Jonathan C. R. Jones, Stephanie Stahl, Sigmund A. Weitzman
  • Treatment of asbestos and silicates to reduce their toxicity
    Patent number: 5154903
    Abstract: This invention pertains to an improved method of inhibiting peroxide-reduction catalytic activity and concomitant toxicity of asbestos and nonasbestos iron-containing silicates. These undesirable reactions can be substantially reduced or essentially eliminated by contacting these potentially harmful materials with an aqueous solution comprising a non-mutagenic non-toxic iron chelating agent, such as phytic acid, diethylenetriamine pentaacetic acid (DTPA) or derivatives of these.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: October 13, 1992
    Assignees: Massachusetts General Hospital, Boston Biomedical Research Institute
    Inventors: Philip J. Graceffa, Sigmund A. Weitzman
  • Treatment of asbestos
    Patent number: 4474742
    Abstract: Toxicity of asbestos is reduced by treating it with non-mutagenic non-toxic hydroxamic acid iron-chelating agents.
    Type: Grant
    Filed: February 17, 1983
    Date of Patent: October 2, 1984
    Assignees: Boston Biomedical Research Institute, Inc., The General Hospital Corporation
    Inventors: Philip Graceffa, Sigmund A. Weitzman