Abstract: The present invention relates to the medical use of compounds acting as inhibitors of enzymes having histone deacetylase activity in conditions where their combination with compounds known as NSAID's, Non Steroidal Anti Inflammatory Drugs, causes an enhanced beneficial therapeutic effect. These conditions comprise cancer, cancer predisposing conditions, inflammatory and metabolic diseases. Furthermore, the invention includes the manufacture of clinically used medicaments for the therapy of the diseases mentioned herein, administering the compounds separately in the form of two individual drugs or in an administrative form which contains both drugs in a single application unit.

Abstract: The present invention relates to methods using newly identified cancer related polynucleotides and the polypeptides encoded by these polynucleotides. The invention further relates to the use of such “cancer antigens” for diagnosing cancer and cancer metastases. The invention relates to the use of these cancer antigens employing expression vectors, host cells, antibodies directed to such cancer antigens, and recombinant methods and synthetic methods for producing the same. Also provided are diagnostic and prognostic methods for detecting, treating, or preventing cancer, for suppressing tumor progression and minimal residual tumor disease, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of the cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polynucleotides and polypeptides of the present invention.