Publication number: 20090105332
Abstract: A compound having the structure of the formula (genus of compound 1 excluding Tashironin or Debenzoyltashironin) wherein, R1 is H or Bz when no more than three of R8, R9, R10 and R11 are H, or R1 is Bn, (C1-C4) alkyl, or CF3; R2 is H, (C1-C4) alkyl, halide, OC(O)(C1-C4)alkyl, OC(O)Ph, or OCF3; R3 is p-toluene sulfonyloxy, methane sulfonyloxy, C(O)(C1-C4)alkyl, or OC(O)(C1-C4)alkyl, bond ? is a single bond, and bond ? is a double bond or R3 is O, bond ? is a double bond and bond ? is a single bond; R4 is H, I, Br, Cl, Si(CH3)3, (C1-C4)alkyl, or OCF3; R5 is OH, OSi(CH3)3, O(C1-C4) alkyl, or OCF3, and bond ? is a single bond, or R5 is O and bond ? is a double bond; R6 is H, (C1-C4) alkyl, or CF3; R7 is H, OH, (C1-C4)alkyl, CH2OBn, CH2O(C1-C4)alkyl, CH2OH, halide, CH2OCF3 or OCF3 and bond ? is a single bond, or R7 is CH2 and bond ? is a double bond; R8, R9, and R10 are each independently H, (C1-C4)alkyl, halide, OH, or OCF3; R11 is H, (C1-C4)alkyl, halide, OH, or OCF3 and bond ? is a single bond; R12 is H, (
Type:
Application
Filed:
December 20, 2005
Publication date:
April 23, 2009
Applicant:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF
Inventors:
Samuel J. Danishefsky, Silas P. Cook