Patents by Inventor Silvano Spinelli

Silvano Spinelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
    Patent number: 9340508
    Abstract: A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: May 17, 2016
    Assignee: CLOVIS ONCOLOGY ITALY S.R.L.
    Inventors: Silvano Spinelli, Valeria Livi
  • Process for the Preparation of 6-(7-((1-Aminocyclopropyl)Methoxy)-6-Methoxyquinolin-4-Yloxy)-N-Methyl-1-Naphthamide and Synthetic Intermediates Thereof
    Publication number: 20150191429
    Abstract: A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
    Type: Application
    Filed: March 18, 2015
    Publication date: July 9, 2015
    Inventors: Silvano Spinelli, Valeria Livi
  • Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
    Patent number: 9012645
    Abstract: A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: April 21, 2015
    Assignee: Clovis Oncology Italy S.R.L.
    Inventors: Silvano Spinelli, Valeria Livi
  • PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF
    Publication number: 20140114075
    Abstract: A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
    Type: Application
    Filed: December 23, 2013
    Publication date: April 24, 2014
    Applicant: EOS ETHICAL ONCOLOGY SCIENCE S.p.A. in abbreviated form EOS S.p.A.
    Inventors: Silvano SPINELLI, Valeria LIVI
  • Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof
    Patent number: 8642767
    Abstract: A process for the preparation in high yields and purity of the compound 6-(7-4(1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: February 4, 2014
    Assignee: EOS Ethical Oncology S.p.A. Abbreviated Form EOS S.p.A.
    Inventors: Silvano Spinelli, Valeria Livi
  • PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF
    Publication number: 20120010415
    Abstract: A process for the preparation in high yields and purity of the compound 6-(7-4(1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
    Type: Application
    Filed: March 11, 2010
    Publication date: January 12, 2012
    Inventors: Silvano Spinelli, Valeria Livi
  • Multinuclear cationic platinum complexes with antitumor activity
    Patent number: 6313333
    Abstract: The present invention relates to tetra- and penta-nuclear platinum complexes with antitumor activity, to a method for preparing them and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: November 6, 2001
    Assignee: Setanta Therapeutics, Inc.
    Inventors: Giovanni Da Re, Roberto Di Domenico, Silvano Spinelli, Nicholas Farrell
  • Bis-phosphonate confugates with alkylating moieties having antitumor activity
    Patent number: 6207655
    Abstract: The present invention relates to conjugates of 3-carboxy-4,4′-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: March 27, 2001
    Assignee: Novuspharma S.p.A.
    Inventors: Valeria Livi, Silvano Spinelli, Marco Conti, Simonetta D'Alo', Ernesto Menta
  • Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
    Patent number: 6069150
    Abstract: The present invention concerns the use of beta-carboline derivatives of formula I bearing at least a free or esterified carboxylic group on the piperidine ring, for the preparation of pharmaceutical compositions having antimetastatic properties.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: May 30, 2000
    Assignee: F. Hoffman-La Roche AG
    Inventors: Silvano Spinelli, Ernesto Menta, Hans-Willi Krell
  • Bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity
    Patent number: 6060616
    Abstract: Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of the complexes for the treatment of tumors in mammals, are disclosed. The method of making the polymethylene derivatives, is also disclosed.
    Type: Grant
    Filed: October 14, 1998
    Date of Patent: May 9, 2000
    Assignees: Hoffmann-La Roche Inc., Virginia Commonwealth University
    Inventors: Nicholas P. Farrell, Erneston Menta, Roberto Di Domenico, Silvano Spinelli
  • 2-[2-[(2-hydroxyethyl)amino]ethy [ l]-5-[[2-methylamino)ethyl]amino]indazolo4,3-gh]isoquinolin-6(2H)-one as antitumor agent
    Patent number: 6034092
    Abstract: The present invention relates to 2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-methylamino)ethyl]amino]indazolo[ 4,3-gh]isoquinolin-6(2H)-one and the pharmaceutically acceptable acid addition salts thereof, of formula (I). This compound has shown a high a antitumor activity.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: March 7, 2000
    Assignee: Novuspharma S.p.A.
    Inventors: Ernesto Menta, Ambrogio Oliva, Silvano Spinelli, Paul Krapcho
  • Bis-platinum complexes with polyamine ligands as antitumor agents
    Patent number: 6022892
    Abstract: Bis-platinum(II) complexes with polyamine ligands, including spermidine and spermine, are disclosed. The method of making the bis-platinum(II) complexes, using a DMF complex, and the use of the bis-platinum complexes for the treatment of tumors in mammals are also disclosed. The method of making the polyamine ligands and the use of a new polyamine compound as an intermediate in the synthesis of polyamine ligands are also disclosed.
    Type: Grant
    Filed: February 22, 1998
    Date of Patent: February 8, 2000
    Assignees: Hoffman-La Roche Inc., Virginia Commonwealth University
    Inventors: Nicholas P. Farrell, Ernesto Menta, Roberto Di Domenico, Silvano Spinelli
  • Trinuclear cationic platinum complexes having antitumor activity and pharmaceutial compositions containing them
    Patent number: 6011166
    Abstract: The present invention relates to trinuclear cationic platinum complexes with alkylene diamine groups connecting the three platinum moieties. The invention also relates to the antitumor activity of these complexes as well as the processes for the preparation thereof and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: January 4, 2000
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Mariella Valsecchi, Paolo Pavesi, Carlo Bugatti, Ernesto Menta, Fernando Giuliani, Carla Manzotti, Silvano Spinelli, Nicholas Farrell
  • Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them
    Patent number: 5744497
    Abstract: Compounds of general formula (I) wherein: n is an integer from 2 to 7 included; Z.sup.-m is an anion selected from chloride, bromide, iodide, nitrate, sulfate; m is the integer 1 or 2. Said compounds have antitumour activity.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: April 28, 1998
    Assignee: Boehringer Mannheim Italia, S.p.A.
    Inventors: Mariella Valsecchi, Marco Conti, Luisa Del Greco, Carlo Bugatti, Ernesto Menta, Ferdinando Giuliani, Carla Manzotti, Silvano Spinelli, Nicholas Farrell
  • Method of synthesis for 6,9-bis((2-aminoethyl)amino)benzo?g!isoquinoline-5,10-dione and its dimaleate salt
    Patent number: 5717099
    Abstract: In the search for novel heteroanalogs of anthracendiones, 6,9-bis?(2-aminoethyl)amino!benzo?g!isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.
    Type: Grant
    Filed: August 1, 1996
    Date of Patent: February 10, 1998
    Assignee: Boehringer Mannheim Italia S.p.A.
    Inventors: Silvano Spinelli, Roberto DiDomenico
  • Method of synthesis for 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione and its dimaleate salt
    Patent number: 5616709
    Abstract: In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 1, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Silvano Spinelli, Roberto DiDomenico
  • 1,4-disubstituted piperazines useful in the therapy of the asthma and of the inflammation of the respiratory tract
    Patent number: 5607930
    Abstract: Compounds of formula (I): ##STR1## wherein Ra, Rb, B and D have the meanings reported in the disclosure, processes for making the same, and methods of using the same in the treatment of asthma and/or inflammation of the respiratory tract are disclosed.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: March 4, 1997
    Assignee: Boehringer Mannheim Italia, S.p.A.
    Inventors: Giorgio Long, Silvano Spinelli, Antonella Rozzi, Simonetta D'Alo', Licia Gallico
  • 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
    Patent number: 5604246
    Abstract: This invention is directed to 2-aminoalkyl-5-aminoalkylamino substituted isoquino[8,7,6-cd]indazole-6-(2H)-ones and to 2-aminoalkyl-5-aminoalkylamino substituted-isoquino[5,6,7-cd]indazole-6(2H)-ones. These compounds have been shown to have antitumor activity.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: February 18, 1997
    Assignees: Boehringer Mannheim Italia SpA, Univ. of Vermont
    Inventors: A. Paul Krapcho, Ernesto Menta, Ambrogio Oliva, Silvano Spinelli
  • Hetero-annulated indazoles
    Patent number: 5596097
    Abstract: This invention is directed to heteroannulated indazoles namely to 2,5-disubstituted quinolino-, isoquinolino-, phthalazino-, and quinoxalino- annulated indazole-6(2H)-ones and related mono N-oxides.These compounds have been shown to have antitumor activity.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: January 21, 1997
    Assignees: The University of Vermont, Boehringer Mannheim Italia, S.p.A.
    Inventors: A. Paul Krapcho, Ernesto Menta, Ambrogio Oliva, Silvano Spinelli
  • 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
    Patent number: 5519029
    Abstract: This invention is directed to 2-aminoalkyl-5-aminoalkylamino substituted isoquino [8,7,6-cd]indazole-6-(2H)-ones and to 2-aminoalkyl-5-aminoalkylamino substituted-isoquino [5,6,7-cd] indazole-6(2H)-ones. These compounds have been shown to have antitumor activity.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: May 21, 1996
    Assignees: Boehringer Mannheim Italia, S.p.A., University of Vermont & State Agricultural College
    Inventors: A. Paul Krapcho, Ernesto Menta, Ambrogio Oliva, Silvano Spinelli