Patents by Inventor Silvia Chen
Silvia Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11933870Abstract: For detecting motion in MR imaging, a regression model, such as a convolutional neural network, is machine trained. To generalize to MR imagers, MR contrasts, or other differences in MR image generation, the regression model is trained adversarially. The discriminator for adversarial training discriminates between classes of the variation source (e.g., type of MR imager or type of contrast) based on values of features learned in the regression model for detecting motion. By adversarial training, the regression model learns features that are less susceptible or invariant to variation in image source.Type: GrantFiled: June 19, 2019Date of Patent: March 19, 2024Assignee: Siemens Healthineers AGInventors: Silvia Bettina Arroyo Camejo, Benjamin L. Odry, Xiao Chen, Mariappan S. Nadar
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Publication number: 20240071495Abstract: Memory circuitry comprising strings of memory cells comprises a stack comprising vertically-alternating insulative tiers and conductive tiers. Channel-material strings of memory cells extend through the insulative tiers and the conductive tiers in a memory-array region. The insulative tiers and the conductive tiers extend from the memory-array region into a stair-step region. The stair-step region comprises a cavity comprising a flight of stairs having insulative material atop treads of the stairs. Individual of the treads comprise conducting material of one of the conductive tiers. Conductive vias extend through the insulative material. Individual of the conductive vias are directly above and directly against the conducting material of the respective individual tread. A lining is over sidewalls of the individual conductive vias. The lining has a bottom. The individual conductive vias are directly under the bottom of the lining directly above the conducting material of the respective individual tread.Type: ApplicationFiled: August 26, 2022Publication date: February 29, 2024Applicant: Micron Technology, Inc.Inventors: Jiewei Chen, Jordan D. Greenlee, Shuangqiang Luo, Silvia Borsari
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Patent number: 11912745Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.Type: GrantFiled: January 7, 2022Date of Patent: February 27, 2024Assignee: University of Maryland, College ParkInventors: Silvia Muro, Jing Chen, Melani Solomon, Kevin Gray
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Publication number: 20240009352Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.Type: ApplicationFiled: September 20, 2023Publication date: January 11, 2024Applicant: LifeNet HealthInventors: Silvia Chen, Grant Cleavenger, Dennis Phelps, Breanne Gjurich, Evans Wralstad, Austin Johnson, Alana Sampson, Adam Entsminger, Jingsong Chen
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Publication number: 20230363374Abstract: An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.Type: ApplicationFiled: July 25, 2023Publication date: November 16, 2023Applicant: LifeNet HealthInventors: Silvia Chen, Austin Johnson, Roberto Bracone
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Patent number: 11730163Abstract: An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.Type: GrantFiled: January 6, 2021Date of Patent: August 22, 2023Assignee: LifeNet HealthInventors: Silvia Chen, Austin Johnson, Roberto Bracone
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Publication number: 20230257696Abstract: The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.Type: ApplicationFiled: April 14, 2023Publication date: August 17, 2023Applicant: LifeNet HealthInventors: Michael Francis, Silvia Chen, Erick Breathwaite, Rudy Rodriguez, Alan Smith, Alexander Huber, Jung Bok Lee
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Publication number: 20230158205Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.Type: ApplicationFiled: January 6, 2023Publication date: May 25, 2023Applicant: LifeNet HealthInventors: Michael Francis, Rudy Rodriquez, Nathan Kemper, Silvia Chen
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Patent number: 11655448Abstract: The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.Type: GrantFiled: May 27, 2016Date of Patent: May 23, 2023Assignee: LifeNet HealthInventors: Michael Francis, Silvia Chen, Erick Breathwaite, Rudy Rodriguez, Alan Smith, Alexander Huber, Jung Bok Lee
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Publication number: 20230079283Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.Type: ApplicationFiled: November 18, 2022Publication date: March 16, 2023Applicant: LifeNet HealthInventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
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Patent number: 11576999Abstract: The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.Type: GrantFiled: August 7, 2020Date of Patent: February 14, 2023Assignee: LifeNet HealthInventors: Michael Francis, Rudy Rodriquez, Nathan Kemper, Silvia Chen
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Patent number: 11533906Abstract: The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.Type: GrantFiled: November 23, 2020Date of Patent: December 27, 2022Assignee: LIFENET HEALTHInventors: Roberto Bracone, Jingsong Chen, Marilyn Gatin, Silvia Chen, James A. Clagett, Daniel Osborne
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Publication number: 20220372438Abstract: The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.Type: ApplicationFiled: July 22, 2022Publication date: November 24, 2022Applicant: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen
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Patent number: 11434469Abstract: The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.Type: GrantFiled: February 9, 2016Date of Patent: September 6, 2022Assignee: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen
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Publication number: 20220184279Abstract: A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.Type: ApplicationFiled: December 20, 2021Publication date: June 16, 2022Applicant: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen, Lindsey Aschenbach, Jingsong Chen
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Patent number: 11207446Abstract: A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.Type: GrantFiled: December 23, 2016Date of Patent: December 28, 2021Assignee: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen, Lindsey Aschenbach, Jingsong Chen
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Publication number: 20210268147Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.Type: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Applicant: LifeNet HealthInventors: Silvia Chen, Grant Cleavenger, Dennis Phelps, Evans Wralstad, Breanne Gjurich, Austin Johnson, Alana Sampson, Adam Entsminger, Jingsong Chen
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Patent number: 11078248Abstract: The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.Type: GrantFiled: December 13, 2018Date of Patent: August 3, 2021Assignee: LifeNet HealthInventors: Xiaofei Qin, Silvia Chen, Jingsong Chen, James Clagett
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Patent number: 11033656Abstract: The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.Type: GrantFiled: June 13, 2017Date of Patent: June 15, 2021Assignee: LifeNet HealthInventors: Silvia Chen, Grant Cleavenger, Dennis Phelps, Evans Wralstad, Breanne Gjurich, Austin Johnson, Alana Sampson, Adam Entsminger, Jingsong Chen
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Patent number: 11020121Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to circular stapling instruments and elongated tubular hollow sleeves deployed from such stapling instruments and establishing an enclosure around the stapled and resected tissues at the anastomotic joint.Type: GrantFiled: July 12, 2019Date of Patent: June 1, 2021Assignee: Cilag GmbH InternationalInventors: Nir I. Nativ, Silvia Chen