Abstract: A flip top cap for containers providing evidence of first opening includes a cover part and a pourer part coupled by a hinge arrangement and produced as a single piece. The cover part is rotatable around the hinge arrangement to be brought from a closed position engaging the pourer part to an open and separate position with respect to the pourer part, an engagement system engaging the cover part after rotation into a closed position on the pourer part. The engagement system is breakable and is arranged partly on the cover part and partly on the pourer part, and remains integral with at least one of the cover or pourer parts when they are broken at the first opening.

Abstract: A cap for a container with a hinged lid includes a first part and a second part that are snap-associated. The first part has a lower cylindrical portion and an upper cylindrical portion, and the second part includes a covering lid having an annular portion and a lid portion and a hinge arrangement therebetween, which includes a strip arranged in a window opening formed in the side surface of the lid portion and open towards the annular portion. The strip has weakened foldable end areas connected to the annular and lid portions, and a folding invitation line that divides the strip into two portions with a central recess therebetween. Folding invitation lines are also provided between the two portions of the strip and an end edge of the opening in the lid portion.

Abstract: A hinged flip-top cap with a tamper-evident inner ring includes a base portion, which extends into a pourer portion, and a flip-top lid. A hinge arrangement connects the flip-top lid to the base portion and is foldable with respect to said base portion, so that flip-top lid can be tilted with respect to the base portion and moved between a closed position above the base portion and an open position detached and rotated from the base portion. The inner ring is position inwardly of the flip-top lid and the base portion and operates as a tamper-evident element that reveals whether a first opening between the flip-top lid and the base portion has been made.

Abstract: A compact cap with an opening block, after opening, for a container having a mouthpiece, includes a base ring preventing separation from the mouthpiece, a protective cap or cover for opening and closing the mouthpiece, a hinge arrangement that makes the base ring and the cover integral, and frangible bridges, which connect a lower edge of the cover with an upper edge of the base ring when the cover is closing on the ring base and the mouthpiece. The hinge arrangement includes a plurality of spaced strips or bridges, which connect the cover and the base ring, and an extension enlarged outwardly, which forms an integral part of an annular collar and is obtained at the lower end of the cover, and which becomes engaged with the mouthpiece when the cover is rotated from a closed position to an open position to provide a stable open position of the cover.

Abstract: A hinged flip-top cap with a tamper-evident inner ring includes a base portion, which extends into a pourer portion, and a flip-top lid. A hinge arrangement connects the flip-top lid to the base portion and is foldable with respect to said base portion, so that flip-top lid can be tilted with respect to the base portion and moved between a closed position above the base portion and an open position detached and rotated from the base portion. The inner ring is position inwardly of the flip-top lid and the base portion and operates as a tamper-evident element that reveals whether a first opening between the flip-top lid and the base portion has been made.

Abstract: A compact fast-opening cap for a container having a mouthpiece with an outer annular perimetric rib, includes a base ring preventing separation from the mouthpiece; a protective cap or cover for opening and closing the mouthpiece; a hinge integrally joining the base ring and the cover; and frangible bridges that connect a lower edge of the cover with an upper edge of the base ring. The hinge includes strips or bridges connecting the cover to the base ring and an extension enlarged outwardly that forms an integral part of a lower end of the cover and that becomes engaged to the perimetric rib of the mouthpiece when the cover rotates around the hinge from a closed to an open position to create a stable positioning in the open position. A multi-thread or multi-start thread. provided inside the cover. is coupled with threads on an external wall of the mouthpiece.

Abstract: A cap for a container with a hinged lid includes a first part and a second part that are snap-associated. The first part has a lower cylindrical portion and an upper cylindrical portion, and the second part includes a covering lid having an annular portion and a lid portion and a hinge arrangement therebetween, which includes a strip arranged in a window opening formed in the side surface of the lid portion and open towards the annular portion. The strip has weakened foldable end areas connected to the annular and lid portions, and a folding invitation line that divides the strip into two portions with a central recess therebetween. Folding invitation lines are also provided between the two portions of the strip and an end edge of the opening in the lid portion.

Abstract: An aseptic cap for containers with evidence of first opening includes a protective cover positioned on a pouring element and produced as a single piece, which has an upper and a lower part connected by frangible bridges facing edges of the upper and the lower parts of the cover, and by a hinge arrangement. The pouring element includes a cylindrical element formed by two sections having different diameters separated by a step defined by a radial annular extension, which protrudes from the lower cylindrical part of the cover and is at least partially inserted in the upper part of the cover. The upper part of the cover has, in its interior, an appendix or flap which extends to rest above the annular extension, to become folded when the cap is mounted, and which is arranged straight downwardly to be abutted above the annular extension after the first opening.

Abstract: A compact cap with an opening block, after opening, for a container having a mouthpiece, includes a base ring preventing separation from the mouthpiece, a protective cap or cover for opening and closing the mouthpiece, a hinge arrangement that makes the base ring and the cover integral, and frangible bridges, which connect a lower edge of the cover with an upper edge of the base ring when the cover is closing on the ring base and the mouthpiece. The hinge arrangement includes a plurality of spaced strips or bridges, which connect the cover and the base ring, and an extension enlarged outwardly, which forms an integral part of an annular collar and is obtained at the lower end of the cover, and which becomes engaged with the mouthpiece when the cover is rotated from a closed position to an open position to provide a stable open position of the cover.

Abstract: A flip top cap for containers providing evidence of first opening includes a cover part and a pourer part coupled by a hinge arrangement and produced as a single piece. The cover part is rotatable around the hinge arrangement to be brought from a closed position engaging the pourer part to an open and separate position with respect to the pourer part, an engagement system engaging the cover part after rotation into a closed position on the pourer part. The engagement system is breakable and is arranged partly on the cover part and partly on the pourer part, and remains integral with at least one of the cover or pourer parts when they are broken at the first opening.

Abstract: A stopper for a container providing evidence of first opening includes an upper part with a protection cap closable on a pouring element and a ridged lower part with an upper hollow cylindrical portion disposed inside the pouring element and a lower cylindrical portion of larger diameter that is internally threaded. A frangible label is positioned between the protection cap, and a security ring is connected with the upper and lower parts with frangible bridges. An annular security crown is connected to the lower part of the stopper by frangible bridges and a cam arrangement, coaxially coupled between an outer surface of the upper hollow cylindrical portion and an inner surface of the pouring element, causes their translation and rotation. The pouring element has a duct passage and a coaxial island shutter which cooperates with a central hole in the upper hollow cylindrical portion of the lower part.

Abstract: An aseptic cap for containers with evidence of first opening includes a protective cover positioned on a pouring element and produced as a single piece, which has an upper and a lower part connected by frangible bridges facing edges of the upper and the lower parts of the cover, and by a hinge arrangement. The pouring element includes a cylindrical element formed by two sections having different diameters separated by a step defined by a radial annular extension, which protrudes from the lower cylindrical part of the cover and is at least partially inserted in the upper part of the cover. The upper part of the cover has, in its interior, an appendix or flap which extends to rest above the annular extension, to become folded when the cap is mounted, and which is arranged straight downwardly to be abutted above the annular extension after the first opening.

Abstract: A stopper for a container providing evidence of first opening includes an upper part with a protection cap closable on a pouring element and a ridged lower part with an upper hollow cylindrical portion disposed inside the pouring element and a lower cylindrical portion of larger diameter that is internally threaded. A frangible label is positioned between the protection cap, and a security ring is connected with the upper and lower parts with frangible bridges. An annular security crown is connected to the lower part of the stopper by frangible bridges and a cam arrangement, coaxially coupled between an outer surface of the upper hollow cylindrical portion and an inner surface of the pouring element, causes their translation and rotation. The pouring element has a duct passage and a coaxial island shutter which cooperates with a central hole in the upper hollow cylindrical portion of the lower part.

Abstract: A reclosable stopper for revealing a first opening includes a base body for positioning on a container mouth (12), from which base body a pouring element extends upwardly, and a protection and closing cap integrally and hingedly connected to the base body. The base body also includes a guarantee ring connected by frangible bridges to a collar. The cap is firmly positioned on the base body for closure. A tamper-proof feature is provided between the base body having the pouring element, and the cap, for revealing a first opening, which includes a double frangible connection system which can be actuated towards the inside of the cap.

Abstract: A recloseable stopper for revealing a first opening includes a base body for positioning on a container mouth (12), from which base body a pouring element extends upwardly, and a protection and closing cap integrally and hingedly connected to the base body. The base body also includes a guarantee ring connected by frangible bridges to a collar. The cap is firmly positioned on the base body for closure. A tamper-proof feature is provided between the base body having the pouring element, and the cap, for revealing a first opening, which includes a double frangible connection system which can be actuated towards the inside of the cap.

Abstract: The present invention relates to methods and means for detecting ADAMTS13 immune complexes in a sample. The methods include the steps of capturing and labelling immune complexes of anti-ADAMTS13 antibodies. Capturing and labelling may be achieved by two different binding units targeting the immune complexes. The invention further relates to diagnosing diseases associated with immunologic ADAMTS13 dysfunction like TTP (thrombotic thrombocytopenic purpura).