Patents by Inventor Silvia Schenone

Silvia Schenone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of inhibiting serum glucocorticoid induced kinase 1 (SGKI) as a treatment for salt and water balance diseases
    Patent number: 11701358
    Abstract: Methods of using serum glucocorticoid induced kinase 1 (SGK1) inhibitors for reducing the development of diseases related to salt and water balance, and in particular, hydrocephalus and/or hypertension, are disclosed herein. Particularly, the present disclosure is directed to the use of SGK1 inhibitors to inhibit transepithelial ion transport, such as in one embodiment, in the choroid plexus of a subject, thereby reducing cerebrospinal fluid (CSF) production or, alternatively, in another embodiment, to inhibit transepithelial sodium transport in the kidney collecting duct thereby reducing sodium reabsorption into the blood.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: July 18, 2023
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Bonnie L. Blazer-Yost, Nicola Perrotti, Silvia Schenone
  • METHODS OF INHIBITING SERUM GLUCOCORTICOID INDUCED KINASE 1 (SGKI) AS A TREATMENT FOR SALT AND WATER BALANCE DISEASES
    Publication number: 20190365765
    Abstract: Methods of using serum glucocorticoid induced kinase 1 (SGK1) inhibitors for reducing the development of diseases related to salt and water balance, and in particular, hydrocephalus and/or hypertension, are disclosed herein. Particularly, the present disclosure is directed to the use of SGK1 inhibitors to inhibit transepithelial ion transport, such as in one embodiment, in the choroid plexus of a subject, thereby reducing cerebrospinal fluid (CSF) production or, alternatively, in another embodiment, to inhibit transepithelial sodium transport in the kidney collecting duct thereby reducing sodium reabsorption into the blood.
    Type: Application
    Filed: February 14, 2018
    Publication date: December 5, 2019
    Inventors: Bonnie L. Blazer-Yost, Nicola Perrotti, Silvia Schenone
  • COMPOUNDS AND USES THEREOF
    Publication number: 20180186796
    Abstract: The present invention refers to 4-amino-substituted pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine derivatives of formula I and IV able to target the Src family kinases (SFKs) such as Src, Fyn and Hck tyrosine kinases as well as Abl tyrosine kinase and uses and method of preparation thereof. In particular, the compounds of the invention are for use in the treatment and/or prevention of cancer, such as neuroblastoma (NB) or glioblastoma multiforme (GBM) or for use in the treatment and/or prevention of neurodegenerative diseases such as taupathies.
    Type: Application
    Filed: October 29, 2015
    Publication date: July 5, 2018
    Applicant: LEAD DISCOVERY SIENA S.R.L.
    Inventors: Maurizio BOTTA, Adriano ANGELUCCI, Elena DREASSI, Silvia SCHENONE, Cristina TINTORI, Giulia VIGNAROLI
  • 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
    Patent number: 8466164
    Abstract: The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumors.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: June 18, 2013
    Assignee: Universita degli Studi di Siena
    Inventors: Silvia Schenone, Francesco Bondavalli, Olga Bruno, Maurizio Botta, Fabrizio Manetti, Marco Radi, Alessandra Santucci, Giovanni Maga, Mauro Bologna, Adriano Angelucci, Annalisa Santucci, Adriano Spreafico, Fabio Carraro, Jurgen Borlak
  • NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-D PYRIMIDINE AND PYRROLO[2,3-D]PYRIMIDINE AND USES THEREOF
    Publication number: 20100249152
    Abstract: The present invention relates to a compound 4-substituted derivative of pyrazolo[3,4-d]pyrimidine or of pyrrolo[2,3-d]pyrimidine having the formula (I) and uses thereof, in particular for the treatment of bone related diseases and tumours.
    Type: Application
    Filed: September 12, 2008
    Publication date: September 30, 2010
    Applicant: UNIVERSITA DEGLI STUDI DI SIENA
    Inventors: Silvia Schenone, Francesco Bondavalli, Olga Bruno, Maurizio Botta, Fabrizio Manetti, Marco Radi, Alessandra Santucci, Giovanni Maga, Mauro Bologna, Adriano Angelucci, Annalisa Santucci, Adriano Spreafico, Fabio Carraro, Jurgen Borlak
  • Substituted pyrazolo[3,4-D]pyrimidines as anti-tumor agents
    Patent number: 7589086
    Abstract: The present invention provides a compound of pyrazolo[3,4-d]pyrimidine having the formula wherein: X=N; R=H, alkylthio, or aminoalkylthio; R1=NHcyclopropyl, NHC3H7, NHC4H9, N(CH2CH3)2, NHCH2CH2OC2H5, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, NHcyclohexyl, 1-hexahydroazepinyl, NHCH2C6H5, or NHCH2CH2C6H5; wherein R3=H, halogen, or alkyl and R5=Cl, Br or OH.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: September 15, 2009
    Assignee: Universita degli Studi di Siena
    Inventors: Francesco Bondavalli, Maurizio Botta, Olga Bruno, Fabrizio Manetti, Silvia Schenone, Fabio Carraro
  • 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
    Publication number: 20070010510
    Abstract: 4-Substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine are described. Compounds are active as antitumoural agents.
    Type: Application
    Filed: May 26, 2004
    Publication date: January 11, 2007
    Inventors: Francesco Bondavalli, Maurizio Botta, Olga Bruno, Fabrizio Manetti, Silvia Schenone, Fabio Carraro