Patents by Inventor Simon Delagrave

Simon Delagrave has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYBRID AAV-ANELLOVECTORS
    Publication number: 20240123083
    Abstract: This invention relates generally to compositions for making and administering anellovectors and uses thereof.
    Type: Application
    Filed: February 7, 2022
    Publication date: April 18, 2024
    Inventors: Simon Delagrave, Kevin James Lebo, Michael James DiBiasio-White, Dhananjay Maniklal Nawandar
  • CHICKEN ANEMIA VIRUS (CAV)-BASED VECTORS
    Publication number: 20240000914
    Abstract: This invention relates generally to compositions for making C A Vectors and uses thereof.
    Type: Application
    Filed: October 29, 2021
    Publication date: January 4, 2024
    Inventors: Simon DELAGRAVE, Fernando Martin DIAZ, Jared David PITTS, Kevin James LEBO, Joseph Louis TIMPONA, Nicole Marie BOISVERT
  • TANDEM ANELLOVIRUS CONSTRUCTS
    Publication number: 20230348933
    Abstract: This invention relates generally to compositions for making anellovectors and uses thereof. For instance, a method herein can comprise providing a nucleic acid construct that comprises a first Anellovirus genome encoding an exogenous effector and a second Anellovirus genome or fragment thereof, arranged in tandem. In some embodiments, the nucleic acid construct results in production of an anellovector comprising an Anellovirus genetic element encoding the exogenous effector, enclosed in a proteinaceous exterior.
    Type: Application
    Filed: June 11, 2021
    Publication date: November 2, 2023
    Inventors: Simon Delagrave, Kevin James Lebo, Dhananjay Maniklal Nawandar, Joseph Louis Timpona
  • BACULOVIRUS EXPRESSION SYSTEMS
    Publication number: 20230340527
    Abstract: This invention relates generally to compositions for making anellovectors and uses thereof. For instance, the disclosure provides compositions and methods for using insect cells to produce Anellovirus proteins, e.g., ORF1.
    Type: Application
    Filed: June 11, 2021
    Publication date: October 26, 2023
    Inventors: Simon Delagrave, Jared David Pitts
  • METHODS OF IDENTIFYING AND CHARACTERIZING ANELLOVIRUSES AND USES THEREOF
    Publication number: 20230227849
    Abstract: This invention relates generally to compositions and methods for administering an anellovector (e.g., a synthetic anellovector) that can be used as a delivery vehicle, e.g., for delivering genetic material, for delivering an effector, e.g., a payload, or for delivering a therapeutic agent or a therapeutic effector to a eukaryotic cell (e.g., a human cell or a human tissue). Also provided are methods for amplifying circular nucleic acids comprising Anellovirus sequences.
    Type: Application
    Filed: June 17, 2021
    Publication date: July 20, 2023
    Inventors: Avak Kahvejian, Erica Gabrielle Weinstein, Roger Joseph Hajjar, Nathan Lawrence Yozwiak, Simon Delagrave, Yann Paul Guy Régis Echelard, Simeon Ungerleider Springer, Cesar A. Arze, Kristian Graugaard Andersen
  • ANELLOSOMES FOR DELIVERING SECRETED THERAPEUTIC MODALITIES
    Publication number: 20230048858
    Abstract: This invention relates generally to anellosomes and compositions and uses thereof.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 16, 2023
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • IN VITRO ASSEMBLY OF ANELLOVIRUS CAPSIDS ENCLOSING RNA
    Publication number: 20220372519
    Abstract: This invention relates generally to compositions for making anellovectors and uses thereof.
    Type: Application
    Filed: June 22, 2022
    Publication date: November 24, 2022
    Inventors: Roger Joseph Hajjar, Simon Delagrave, Kurt Adam Swanson
  • ANELLOVIRUS COMPOSITIONS AND METHODS OF USE
    Publication number: 20220362315
    Abstract: This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.
    Type: Application
    Filed: June 21, 2022
    Publication date: November 17, 2022
    Inventors: Simon Delagrave, Fernando Martin Diaz, Avak Kahvejian, Kevin James Lebo, Dhananjay Maniklal Nawandar, Jared David Pitts, Ryan D. Tedstone, Erica Gabrielle Weinstein, Nathan Lawrence Yozwiak
  • Anellovirus compositions and methods of use
    Patent number: 11446344
    Abstract: This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: September 20, 2022
    Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Simon Delagrave, Fernando Martin Diaz, Avak Kahvejian, Kevin James Lebo, Dhananjay Maniklal Nawandar, Jared David Pitts, Ryan D. Tedstone, Erica Gabrielle Weinstein, Nathan Lawrence Yozwiak
  • HERPESVIRUS COMPOSITIONS AND RELATED METHODS
    Publication number: 20220133881
    Abstract: The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable excepients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compostions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.
    Type: Application
    Filed: January 14, 2022
    Publication date: May 5, 2022
    Inventors: Stephen ANDERSON, Simon DELAGRAVE, John HAMBERGER, Qinglian LI, Sophia MUNDLE, Nausheen RAHMAN
  • ICP0-mediated enhanced expression system
    Patent number: 11286465
    Abstract: Methods and compositions for increasing the production of recombinant proteins by introducing ICP0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: March 29, 2022
    Assignee: SANOFI PASTEUR INC.
    Inventors: Simon Delagrave, CharChang Lai
  • ANELLOSOMES FOR DELIVERING PROTEIN REPLACEMENT THERAPEUTIC MODALITIES
    Publication number: 20220073950
    Abstract: This invention relates generally to anellosomes and compositions and uses thereof.
    Type: Application
    Filed: December 12, 2019
    Publication date: March 10, 2022
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • Herpesvirus compositions and related methods
    Patent number: 11260123
    Abstract: The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at least two or more pharmaceutically acceptable exctpients, at least one of which is histidine and at least one of which is a sugar or sugar alcohol. The compositions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: March 1, 2022
    Assignees: SANOFI PASTEUR LIMITED, SANOFI PASTEUR BIOLOGICS, LLC
    Inventors: Stephen Anderson, Simon Delagrave, John Hamberger, Qinglian Li, Sophia Mundle, Nausheen Rahman
  • ANELLOSOMES FOR DELIVERING INTRACELLULAR THERAPEUTIC MODALITIES
    Publication number: 20220040117
    Abstract: This invention relates generally to anellosomes and compositions and uses thereof.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 10, 2022
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • ANELLOSOMES AND METHODS OF USE
    Publication number: 20220042042
    Abstract: This invention relates generally to anellosomes and compositions and uses thereof.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 10, 2022
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • Purification of herpes virus
    Patent number: 11224650
    Abstract: The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion exchange chromatography and tangential flow filtration.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: January 18, 2022
    Assignee: SANOFI PASTEUR BIOLOGICS, LLC
    Inventors: Sophia Mundle, Stephen Anderson, Simon Delagrave
  • Anellovirus compositions and methods of use
    Patent number: 11166996
    Abstract: This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: November 9, 2021
    Assignee: FLAGSHIP PIONEERING INNOVATIONS V, INC.
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • ANELLOVIRUS COMPOSITIONS AND METHODS OF USE
    Publication number: 20200188456
    Abstract: This invention relates generally to viral vectors and viral particles based on Anelloviruses, which can be used to deliver an agent (e.g., an exogenous effector or an endogenous effector, e.g., a therapeutic effector) to a cell (e.g., a cell in a subject to be treated therapeutically). Described herein are anellosomes, anellovectors, and compositions and uses thereof.
    Type: Application
    Filed: June 21, 2019
    Publication date: June 18, 2020
    Inventors: Erica Gabrielle Weinstein, Avak Kahvejian, Simon Delagrave, Nathan Lawrence Yozwiak, Kevin James Lebo, Fernando Martin Diaz, Dhananjay Maniklal Nawandar, Ryan D. Tedstone, Jared David Pitts
  • PURIFICATION OF HERPES VIRUS
    Publication number: 20190328866
    Abstract: The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion exchange chromatography and tangential flow filtration.
    Type: Application
    Filed: July 8, 2019
    Publication date: October 31, 2019
    Inventors: Sophia Mundle, Stephen Anderson, Simon Delagrave
  • Compositions and methods for the production of alpha-herpesviruses
    Patent number: RE47768
    Abstract: The present invention relates to virus growth media that improve the yield of alpha-herpesviruses (e.g., HSV-2) grown in cell cultures. The growth media of the invention include two additives, a disaccharide and a lipid mixture, that can be added to serum-free or serum-enriched growth media to improve the efficiency of virus production. The invention further provides methods of producing alpha-herpesviruses (e.g., HSV-2) in such growth media.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: December 17, 2019
    Assignee: Sanofi Pasteur Biologics LLC
    Inventors: Simon Delagrave, Rachid Oubelaid, John Hamberger