Patents by Inventor Simon Evan Hufton

Simon Evan Hufton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compatible display vector systems
    Patent number: 9523092
    Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: December 20, 2016
    Assignee: Wyeth LLC
    Inventors: Simon Evan Hufton, William James Jonathan Finlay
  • Compatible display vector systems
    Patent number: 8313942
    Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: November 20, 2012
    Assignee: Wyeth LLC
    Inventors: Simon Evan Hufton, William James Jonathan Finlay
  • HUMANIZED ANTI-RAGE ANTIBODY
    Publication number: 20100143349
    Abstract: Compositions comprising antigen binding polypeptides that bind specifically to Receptor For Advanced Glycation End-product (RAGE) and comprises: one or more complementarity determining regions (CDRs) with improved binding efficiency over a parental monoclonal antibody to RAGE are described. Antibodies containing the CDR's and methods of treating a RAGE-related disease or disorder comprising administering to the subject a therapeutically effective amount of the compositions of the invention are also provided.
    Type: Application
    Filed: August 12, 2009
    Publication date: June 10, 2010
    Applicant: Wyeth
    Inventors: Simon Evan Hufton, William James Jonathan Finlay, Orla Margaret Cunningham, Alfredo Darmanin Sheehan, Xuemei Germaine, Matthew Allister Lambert
  • SINGLE CHAIN ANTIBODY LIBRARY DESIGN
    Publication number: 20100124764
    Abstract: The invention provides polynucleotide vectors and linkers and methods for designing and making single chain variable fragment (“ScFv”) libraries. The invention also provides polynucleotide vectors and linkers and methods for reformatting the ScFv library into Fab and IgG formats for high throughput production and screening.
    Type: Application
    Filed: September 25, 2009
    Publication date: May 20, 2010
    Applicant: Wyeth
    Inventors: Simon Evan Hufton, William James Jonathan Finlay, Ian David Broadbent, Laird Bloom
  • COMPATIBLE DISPLAY VECTOR SYSTEMS
    Publication number: 20100120634
    Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.
    Type: Application
    Filed: September 25, 2009
    Publication date: May 13, 2010
    Applicant: Wyeth
    Inventors: Simon Evan HUFTON, William James Jonathan FINLAY
  • COMPATIBLE DISPLAY VECTOR SYSTEMS
    Publication number: 20100113304
    Abstract: The present invention provides a polynucleotide vector system used during polypeptide display that can be used to facilitate transfer of pools of polynucleotides encoding antigen binding proteins of interest. The present invention also provides methods that allow seamless conversion of pools of polynucleotides encoding antigen binding proteins using a restriction enzyme digestion and ligation strategy.
    Type: Application
    Filed: September 25, 2009
    Publication date: May 6, 2010
    Applicant: WYETH
    Inventors: Simon Evan Hufton, William James Jonathan Finlay