Patents by Inventor Simon H. Friedman

Simon H. Friedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DRUG CONJUGATES WITH PHOTOCLEAVABLE SOLUBILITY MODULATORS
    Publication number: 20200147215
    Abstract: The present invention is directed to a composition suitable for forming an implanted light activated drug depot, methods of making the composition, and methods and systems for using the composition. The composition comprises a plurality of drug conjugates, which comprise a drug molecule and a small solubility modulating portion. The drug conjugates are insoluble upon implantation as a drug depot into a subject, and the drug is preferably soluble once cleaved from the depot. One aspect of the invention is directed to a drug conjugate having a modulating portion that modifies the solubility of the drug conjugate by employing a hydrophobic non-polar moiety. Another aspect of the invention is directed to a drug conjugate having a modulating portion that modifies the solubility of the drug by employing a charged moiety that shifts the isoelectric point of the drug conjugate to a physiological pH.
    Type: Application
    Filed: April 24, 2018
    Publication date: May 14, 2020
    Inventors: SIMON H. FRIEDMAN, KARTHIK NADENDLA, BHAGYESH SARODE, PIYUSH JAIN, DIPU KARUNAKARAN, SWETHA CHINTALA, PARTH SHAH
  • PHOTOCLEAVABLE DRUG CONJUGATES
    Publication number: 20190125870
    Abstract: Novel photocleavable drug conjugates for forming drug depots comprise drugs attached to photocleavable groups. The drug is crosslinked via photocleavable group(s) to themselves to form a photocleavable drug conjugate that generally forms the depot.
    Type: Application
    Filed: December 19, 2018
    Publication date: May 2, 2019
    Inventors: SIMON H. FRIEDMAN, PIYUSH K. JAIN, DIPU KARUNAKARAN, BHAGYESH R. SARODE
  • Photocleavable drug conjugates
    Patent number: 10159735
    Abstract: Novel photocleavable drug conjugates for forming drug depots comprise drugs attached to photocleavable groups. In one embodiment, the drug is linked via photocleavable group(s) to a polymer chain to form a photocleavable drug-polymer conjugate that generally forms the depot matrix. In another embodiment, the drug is crosslinked via photocleavable group(s) to themselves to form a photocleavable drug conjugate that generally forms the depot.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: December 25, 2018
    Assignee: The Curators of the University of Missouri
    Inventors: Simon H. Friedman, Piyush K. Jain, Dipu Karunakaran, Bhagyesh R. Sarode
  • PHOTOCLEAVABLE DRUG CONJUGATES
    Publication number: 20150328314
    Abstract: Novel photocleavable drug conjugates for forming drug depots comprise drugs attached to photocleavable groups. In one embodiment, the drug is linked via photocleavable group(s) to a polymer chain to form a photocleavable drug-polymer conjugate that generally forms the depot matrix. In another embodiment, the drug is crosslinked via photocleavable group(s) to themselves to form a photocleavable drug conjugate that generally forms the depot.
    Type: Application
    Filed: June 21, 2013
    Publication date: November 19, 2015
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: SIMON H. FRIEDMAN, PIYUSH K. JAIN, DIPU KARUNAKARAN, BHAGYESH R. SARODE
  • Method of treatment of viral infection including HIV using water soluble fullerenes—III
    Patent number: 6979566
    Abstract: A water soluble derivative of buckministerfullerene (C50) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.
    Type: Grant
    Filed: February 1, 2003
    Date of Patent: December 27, 2005
    Assignee: The Regents of the University of California
    Inventors: Simon H. Friedman, Raymond F. Schinazi, Fred Wudl, Craig L. Hill, Diane L. DeCamp, Rintje P. Sijbesma, George L. Kenyon
  • Method of treatment of viral infection including HIV using water soluble fullerenes - III
    Publication number: 20040044062
    Abstract: A water soluble derivative of buckministerfullerene (C50) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.
    Type: Application
    Filed: February 1, 2003
    Publication date: March 4, 2004
    Inventors: Simon H. Friedman, Raymond F. Schinazi, Fred Wudl, Craig L. Hill, Diane L. DeCamp, Rintje P. Sijbesma, George L. Kenyon
  • Method of treatment of viral infection including HIV using water soluble fullerenes
    Patent number: 6613771
    Abstract: A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: September 2, 2003
    Assignee: The Regents of the University of California
    Inventors: Simon H. Friedman, Raymond F. Schinazi, Fred Wudl, Craig L. Hill, Diane L. DeCamp, Rintje P. Sijbesma, George L. Kenyon
  • Water soluble fullerenes with antiviral activity
    Publication number: 20010041801
    Abstract: A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.
    Type: Application
    Filed: January 25, 2001
    Publication date: November 15, 2001
    Applicant: The Regents of the University of California
    Inventors: Simon H. Friedman, Raymond F. Schinazi, Fred Wudl, Craig L. Hill, Diane L. DeCamp, Rintje P. Sijbesma, George L. Kenyon
  • Water soluble fullerenes with antiviral activity
    Patent number: 6204391
    Abstract: A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: March 20, 2001
    Assignee: The Regents of the University of California
    Inventors: Simon H. Friedman, Raymond F. Schinazi, Fred Wudl, Craig L. Hill, Diane L. DeCamp, Rintje P. Sijbesma, George L. Kenyon
  • Water soluble fullerenes with antiviral activity
    Patent number: 5811460
    Abstract: A water soluble derivative of buckministerfullerene (C.sub.60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: September 22, 1998
    Assignee: The Regents of the University of California
    Inventors: Simon H. Friedman, Raymond F. Schinazi, Fred Wudl, Craig L. Hill, Diane L. De Camp, Rintje P. Sijbesma, George L. Kenyon
  • Chemical prevention or reversal of cataract by phase separation inhibitors
    Patent number: 5290813
    Abstract: The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: March 1, 1994
    Assignee: Massachusetts Institute of Technology
    Inventors: John I. Clark, Geroge B. Benedek, Roelant J. Siezen, John A. Thomson, Simon H. Friedman
  • Chemical prevention or reversal of cataract by phase separation inhibitors
    Patent number: 5091421
    Abstract: The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.
    Type: Grant
    Filed: December 15, 1989
    Date of Patent: February 25, 1992
    Assignee: Massachusetts Institute of Technology
    Inventors: John I. Clark, George B. Benedek, Roelant J. Siezen, John A. Thomson, Simon H. Friedman