Patents by Inventor Simon J. T. Mao

Simon J. T. Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anticoagulant peptides
    Patent number: 6005071
    Abstract: This invention relates to peptide derivatives which are useful anticoagulant agents.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: December 21, 1999
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
    Patent number: 5962435
    Abstract: A method of lowering plasma cholesterol level in a patient with hypercholesterolemia, by administration of a compound of formula (1) ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group;Z is a thio, oxy or methylene group;A is a C.sub.1 -C.sub.4 alkylene group; andR.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar)wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: October 5, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Simon J. T. Mao, Mark T. Yates, Roger A. Parker
  • Anticoagulant peptides
    Patent number: 5789540
    Abstract: This invention relates to peptide derivatives which are useful anticoagulant agents.
    Type: Grant
    Filed: March 28, 1995
    Date of Patent: August 4, 1998
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
    Patent number: 5677291
    Abstract: A method of lowering plasma cholesterol level in a patient with hypercholesterolemia, by administration of a compound of formula (1) ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group;Z is a thio, oxy or methylene group;A is a C.sub.1 -C.sub.4 alkylene group; andR.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar)wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl.
    Type: Grant
    Filed: January 2, 1996
    Date of Patent: October 14, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Simon J. T. Mao, Mark T. Yates, Roger A. Parker
  • Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
    Patent number: 5541161
    Abstract: This invention relates to peptide derivatives which are useful anticoagulant agents.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: July 30, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents
    Patent number: 5532400
    Abstract: This invention relates to certain 2,6-di-alkyl-4-silyl-phenols which are useful as inhibitors of LDL lipid peroxidation and as antiatherosclerotic agents.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: July 2, 1996
    Assignee: Merrell Pharmaceuticals Inc.
    Inventors: Roger A. Parker, Simon J. T. Mao
  • Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents
    Patent number: 5304668
    Abstract: The present invention relates to certain bis[4-(2,6-dialkyl)phenol]silane derivatives which are useful as inhibitors of LDL lipid peroxidation and as antiatherosclerotic agents.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: April 19, 1994
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Roger A. Parker, Simon J. T. Mao
  • bis[4-(2,6-di-alkyl)phenol]silane derivatives as antiatherosclerotic agents
    Patent number: 5281738
    Abstract: The present invention relates to certain bis[4-(2,6-dialkyl)phenol]silane derivatives which are useful as inhibitors of LDL lipid peroxidation and as antiatherosclerotic agents.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: January 25, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Roger A. Parker, Simon J. T. Mao
  • Radiolabeled anticoagulant peptides
    Patent number: 5279812
    Abstract: This invention relates to the usage of anticoagulant peptide derivatives that are iodinated.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: January 18, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • Cyclic anticoagulant peptides
    Patent number: 5236898
    Abstract: This invention relates to cyclic peptide derivatives which are useful anticoagulant agents.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: August 17, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • Cyclic anticoagulant peptides
    Patent number: 5192745
    Abstract: This invention relates to cyclic peptide derivatives which are useful anticoagulant agents.
    Type: Grant
    Filed: September 23, 1991
    Date of Patent: March 9, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John L. Krstenansky, Simon J. T. Mao
  • 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
    Patent number: 5155250
    Abstract: This invention relates to certain 2,6-di-alkyl-4-silyl-phenols which are useful as inhibitors of LDL lipid peroxidation and as antiatherosclerotic agents.
    Type: Grant
    Filed: July 5, 1990
    Date of Patent: October 13, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Roger A. Parker, Simon J. T. Mao
  • Hypotriglyceridemic use of certain bis (3,5-di-alkyl-4-hydroxyphenylthio)methanes
    Patent number: 5122542
    Abstract: The present invention relates to a method of lowering plasma triglycerides in a patient in need thereof comprising administering to said patient an effective hypotriglyceridemic amount of a bis(3,5-di-alkyl-4-hydroxyphenylthio)methane.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: June 16, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Simon J. T. Mao, George Ku, Richard L. Jackson
  • Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis
    Patent number: 5112870
    Abstract: This invention relates to a method of inhibiting the development of a cataract in a patient in need thereof comprising administering to said patient an effective cataract inhibitory amount of a bis(alkyl-substituted-4-hydroxyphenylthio)alkane analog.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: May 12, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Simon J. T. Mao, Richard L. Jackson
  • Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis
    Patent number: 5061734
    Abstract: This invention relates to a method of inhibiting the development of a cataract in a patient in need thereof comprising administering to said patient an effective cataract inhibitory amount of a bis(alkyl-substituted-4-hydroxyphenylthio)alkane analog.
    Type: Grant
    Filed: May 9, 1990
    Date of Patent: October 29, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Simon J. T. Mao, Richard L. Jackson
  • Method of treating diabetes mellitus with bisphenol derivatives
    Patent number: 5021461
    Abstract: The present invention relates to a method of lowering blood glucose in a patient afflicted with diabetes mellitus comprising administering to said patient a therapeutically effective glucose lowering amount of a 4,4'-bis(2,6-di-alkylphenol). The present invention also relates to a process for making 4,4'-bis(2,6-di-alkyl-phenol).
    Type: Grant
    Filed: August 21, 1990
    Date of Patent: June 4, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Keith M. Robinson, Simon J. T. Mao, Roger A. Parker, Richard L. Jackson
  • Method of treating diabetes mellitus with bisphenol derivatives
    Patent number: 5001282
    Abstract: The present invention relates to a method of lowering blood glucose in a patient afflicted with diabetes mellitus comprising administering to said patient a therapeutically effective glucose lowering amount of a 4,4'-bis(2,6-di-alkyl-phenol). The present invention also relates to a process for making 4,4'-bis(2,6-di-alkyl-phenol).
    Type: Grant
    Filed: July 26, 1989
    Date of Patent: March 19, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Keith M. Robinson, Simon J. T. Mao, Roger A. Parker, Richard L. Jackson
  • Method of treating diabetes mellitus
    Patent number: 4959392
    Abstract: The present invention relates to a method of lowering blood glucose in a patient afflicted with diabetes mellitus comprising administering to said patient a therapeutically effective glucose lowering amount of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: September 25, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Keith M. Robinson, Simon J. T. Mao, Richard L. Jackson
  • Hypocholesterolemic use of bis(3,5-di-tertiary-butly-4-hydroxyphenylthio)methane
    Patent number: 4954528
    Abstract: The present invention relates to a method of lowering total serum cholesterol in a patient in need thereof comprising administering to said patient a therapeutically effective hypocholesterolemic amount of bis(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane.
    Type: Grant
    Filed: November 15, 1989
    Date of Patent: September 4, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Simon J. T. Mao, Richard L. Jackson
  • Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
    Patent number: 4900757
    Abstract: The present invention relates to the use of bis(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane in treating atherosclerosis and/or hypercholesterolemia in patients suffering therefrom.
    Type: Grant
    Filed: December 8, 1988
    Date of Patent: February 13, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Simon J. T. Mao, Richard L. Jackson