Abstract: The present invention includes compounds of formula (I) and methods for its preparation and treatment of disorders with activated peroxisome preoliferator-activated receptor gamma (PPARG), particularly cancer.

Abstract: Disclosed herein is a solar light kit and a method of assembling the solar light kit, the kit comprising: a printed circuit board (PCB) housing configured to enclose a first PCB and second PCB, wherein the first PCB comprises an array of light sources and the second PCB comprises a plurality of electrical ports, the first PCB and second PCB are configured to connect and fit in the PCB housing in one orientation; a battery housing configured to enclose at least one rechargeable battery, wherein the battery housing is configured to connect to the PCB housing; a casing configured to enclose the connected PCB housing and battery housing; and a solar panel configured to connect to the second PCB using a connector cable removably connectable to the solar panel and the second PCB.

Abstract: Examples for validating the identify of an application in an inter-app communication protocol are described. An attestation payload is obtained from a third party attestation service that is executed remotely from a device on which the application is running. The attestation payload can be validated by another application on the device in order to validate the identity of the application providing the attestation payload.

Abstract: Automated query retry includes selecting a first node of a plurality of nodes of an execution platform in response to a query. The first node is configured with a first version of a database platform. A first execution of the query is performed using the first version of the database platform at the first node. The method further includes detecting the first execution results in a failed execution. A second execution of the query is scheduled. The second execution uses at least one of the first version of the database platform or a second version of the database platform configured at a second node of the plurality of nodes. The second version is released after the first version. A cause of the failed execution of the query at the first node is determined based at least in part on a result of the second execution of the query.

Abstract: This invention relates generally to compositions for making and administering anellovectors and uses thereof.

Abstract: A sensor module assembly for a respiratory therapy apparatus may be configured for a seal-based securement within a respiratory therapy device that includes a separable pneumatic block to make assembly or replacement more efficient. The sensor module assembly may include a flow manifold. The flow manifold may have an inlet and an outlet and a main pneumatic path between the inlet and the outlet. The assembly may have a sensor module with sensor(s) on a printed circuit board. The sensor module may be pneumatically and fixedly coupled to the flow manifold. The inlet of the flow manifold may be configured for removable coupling with an outlet of the pneumatic block assembly. Moreover, the outlet of the flow manifold may be configured for removable coupling with a pneumatic path of a housing panel of the respiratory therapy apparatus. The pneumatic path is adapted for supplying breathable gas to a patient interface.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.

Abstract: A breathing assistance apparatus and method of controlling a breathing assistance apparatus is disclosed. Particularly, the breathing assistance apparatus is controlled such that it has a drying cycle to enable drying of the tubing that supplies gases to a user and prevent the harbouring of pathogens within the tube. The drying cycle is preferably operated automatically by internal controllers in the apparatus. However, it may be manually activated by pressing a button on the apparatus. The drying cycle is preferably activated at the end of a user's treatment session.

Abstract: According to one aspect, an electric toothbrush may include a handle, a brush head, a rechargeable battery, an electric motor, and a pair of electrical contacts. The handle may have a first end region and a second end region defining a longitudinal axis therebetween, the handle defining a volume from the first end region to the second end region. The brush head may include bristles, the brush head releasably securable to the first end region of the handle. The rechargeable battery may be in the volume. The electric motor may be at least partially disposed in the volume, the electric motor in electrical communication with the rechargeable battery, the electric motor in mechanical communication with the brush head. The pair of electrical contacts may be in electrical communication with the rechargeable battery, and the pair of electrical contacts axially and radially spaced from one another, relative to the longitudinal axis.

Abstract: A retractable fuselage mounted landing gear assembly is disclosed. The landing gear assembly includes a main strut, a drag stay and a landing gear main fitting. A first end of the drag stay is attached to the main strut and a second end of the drag stay is connected to the fuselage. A first end of the landing main fitting is attached to the main strut and a second end of the main fitting is connected to the fuselage. When the landing gear is extended, substantially all the landing gear loads are transferred from the landing gear to the fuselage via one or more of the drag stay and the main fitting.

Abstract: A coating thickness measuring instrument comprising: a magnetic induction probe comprising at least one drive coil and at least one pick-up coil; a driver for driving an alternating current in the or each drive coil; and a detector for detecting the output of the or each pick-up coil; and a processor configured to: apply a transfer function to the detector output to produce an output which corresponds to a measured coating thickness; and, scale both the drive current and detector output simultaneously in response to the output. The scaling may be changed in a step-wise manner. The scaling applied to the drive current may be inversely proportional to the scaling applied to the detector output. The scaling may be defined by a first and second scaling factor, stored as a pair. The instrument may store two or more pairs of scaling factors and select a pair in response to the measured coating thickness.

Abstract: A nerve regeneration device comprising a bioresorbable conduit and a matrix contained therein having elongate pores aligned with the longitudinal axis of the conduit. The matrix comprises collagen, fibronectin, laminin-1, and laminin-2, wherein the amount, by weight, of laminin-1 or laminin-2 is greater than the amount of fibronectin in the matrix.

Abstract: An implement for use with an excavator includes a lightweight housing, a first coupling feature, a ground penetrating radar antenna, a controller, a wireless communication circuit and a rotation unit. The lightweight housing has an upper surface, a lower surface and a cavity. The first coupling feature is located on the upper surface and cooperates with a second coupling feature on an excavator arm. The ground penetrating radar antenna is mounted near the lower surface. The controller is mounted within the cavity and provides outgoing signals to the radar antenna, receives incoming signals from the radar antenna and interprets the incoming signals so as to provide implement output information. The wireless communication circuit is mounted within the cavity and transmits the implement output information. The rotation unit is mounted within the cavity and rotates the housing vis-à-vis the excavator arm.

Abstract: An interactive toy comprising a function device for performing user-perceptible, controllable functions. The interactive toy also includes a rechargeable power source and a charging circuit for contactless receipt of electrical energy and for charging the rechargeable power source when the interactive toy is positioned in a charging zone of a contactless charging device. The interactive toy is adapted to determine a charging rate at respective positions relative to the charging device and to generate a user-perceptible output indicative of the determined charging rate.

Abstract: An input device includes a control surface for a color correction system. The control surface includes a housing with an upwardly facing control panel. The control panel has a proximal edge which is nearest a user and a distal edge that is furthest from a user in normal use. The control panel includes a plurality of controls. The plurality of controls includes: a plurality of trackballs, wherein each trackball comprises a ball and a control ring, said ball cooperating with at least one encoder to generate a multi-dimensional control signal based on motion of the ball, and said control ring cooperating with at least one encoder to generate a one dimensional control signal based on the rotational motion of the ring, wherein the ball of said trackball is mounted concentrically with said control ring; a plurality of control buttons; and a plurality of knobs coupled to respective rotary encoders.

Abstract: Disclosed are various examples for an application settings module that provides uniform access to diverse types of data, such as mobile device settings. A client device, such as a mobile device, can be configured through execution of program instructions to access a schema file comprising a definition of a plurality of keypaths, where individual ones of the plurality of keypaths uniquely correspond to one of a plurality of device settings and the keypaths are defined in the schema file in association with a plurality of methods. The client device can identify a function invoked using one of the keypaths to read or write a corresponding one of the device settings, whether stored locally or remote, and, in response to the function being invoked, execute a portion of the methods corresponding to the one of the keypaths in the schema file and return a result to a requesting process.