Abstract: A processing device has a plurality of interfaces and a plurality of processors. During different phases of execution of a computer program, different processors are associated with different interfaces, such that the connectivity between processors and interfaces for the sending of egress data and the receiving of ingress data may change during execution of that computer program. The change in this connectivity is directed by the compiled code running on the processors. The compiled code selects which buses associated with which interfaces, given processors are to connect to for receipt of ingress data. Furthermore, the compiled code causes control messages to be sent to circuitry associated with the interfaces, so as to control which buses associated with which processors, given interfaces are to connect to.

Abstract: A multi-tile processing unit in which the tiles in the processing unit may be divided between two or more different external sync groups for performing barrier synchronisations. In this way, different sets of tiles of the same processing unit each sync with different sets of tiles external to that processing unit.

Abstract: The invention provides methods for manufacturing optimized CAR T cell therapies and uses thereof. Specifically, the invention provides parameters that can be measured, e.g., evaluated, to manufacture CAR T cell therapies with optimized properties. The invention further provides methods of use in connection with said optimized CAR T cells.

Abstract: The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).

Abstract: An augmented reality system for assisting the driver of a vehicle comprising a display headset, a positioning system and a display driver configured to generate graphic elements which appear to the driver to move independently with respect to one another.

Abstract: An augmented reality system for assisting the driver of a vehicle comprising a display headset, a positioning system and a display driver configured to generate graphic elements which appear to the driver to move independently with respect to one another.

Abstract: The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule.

Abstract: The invention provides methods for manufacturing optimized CAR T cell therapies and uses thereof. Specifically, the invention provides parameters that can be measured, e.g., evaluated, to manufacture CAR T cell therapies with optimized properties. The invention further provides methods of use in connection with said optimized CART cells.

Abstract: Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

Abstract: The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).

Abstract: A temperature regulation apparatus for a hybrid vehicle having a forced induction combustion engine and an electric drive motor, the apparatus comprising: a temperature regulating circuit carrying a fluid coolant; a heat exchanger for cooling the coolant; and a first coolant pump for circulating the coolant around the temperature regulating circuit; the temperature regulating circuit having: a first branch serving a charge air cooler of a forced induction combustion engine; and a second branch serving one or more electric drive components and including a second coolant pump for regulating the flow of the coolant through the one or more electric drive components; wherein the first and second branches of the temperature regulating circuit are arranged in parallel and the first coolant pump is arranged between the heat exchanger and the first and second branches of the temperature regulating circuit so as to be operable to circulate coolant from each of the first and second branches of the temperature regulating

Abstract: The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 of BKV VP1, and are processed in vivo in natural infection with BKV. Effector T cell populations stimulated by the peptides represent functional CTLs as assessed by cytotoxicity and cytokine production, and are reactive against cells presenting both the BKV peptides above and the JC virus homolog sequences.

Abstract: An EMI/RFI shield includes a shell made from a metalized polymeric material with a shape that is predetermined to form within at least one shielded cavity. The shell has sidewalls that terminate in a flange extending at an angle to the sidewalls. The flange has a lower surface for electrically coupling the shell to a predetermined electrical potential and an upper surface for engaging a structure, preferably a protruding rib from a cover, that exerts a compressive force on the top surface for urging the lower surface into an electrical coupling arrangement with an underlying planar conductor carrying the predetermined electrical potential (e.g., ground). The lower surface can include or be placed upon a layer of electrically conductive compliant material, such as a conductive adhesive. At least one of the sidewalls can include a projecting fluted structure having a size and location that is predetermined to engage a side of the structure that exerts the compressive force.