Abstract: The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-KB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Abstract: A track system of a vehicle can be monitored (e.g., during operation of the vehicle) to obtain information about the track system which can be used for various purposes, such as, for example, to convey the information about the track system to a user (e.g., an operator of the vehicle) and/or to control the vehicle, for instance, by controlling a speed of the vehicle depending on a state (e.g., a temperature and/or one or more other physical characteristics) of the track system. This may be useful, for example, to gain knowledge about a track of the track system, to help prevent rapid wear or other deterioration of the track of the track system (e.g., blowout), and/or to adapt how fast or slow the vehicle moves in order to protect the track of the track system while permitting the speed of the vehicle to be greater over short periods (e.g., when travelling on or crossing roads or other particular areas).

Abstract: A hemofilter system. In one embodiment, the hemofilter system includes a container having a first surface, a second surface, and one or more wall surfaces, the first surface, the second surface and the one or more wall surfaces defining a volume; an input port in fluid communication with the first surface; an output port in fluid communication with the second surface; a filter bed comprising a plurality of planar magnetic meshes stacked in close juxtaposition and positioned within the container volume and coplanar with the first and second surfaces; a first magnet positioned on a first surface of the container; a second magnet positioned on the second surface of the container; a first input conduit in fluid communication with the input port; and a first output conduit in fluid communication with the output port. In another embodiment, the hemofilter system includes a pump in the input conduit.

Abstract: In the field of electrical power systems there is provided a method of supervising the operation of a plurality of current transformers that are arranged in respective current transformer within differing protection zones of a multi-phase electrical power system. The method of supervising comprises the steps of: (a) identifying a faulty protection zone within the electrical power system; (b) identifying a faulty current transformer group within the faulty protection zone; and (c) identifying faulty phase(s) within the faulty current transformer group within the faulty protection zone.

Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.

Abstract: A track for traction of a vehicle, such as an agricultural vehicle, an industrial vehicle (e.g., a construction vehicle), a military vehicle, or another off-road vehicle, is provided. The track comprises a ground-engaging outer surface for engaging the ground and a plurality of traction projections projecting from the ground-engaging outer surface and distributed in a longitudinal direction of the track. The traction projections may be designed to enhance their resistance to deterioration during use. For example, a blowout resistance of each traction projection may be enhanced to prevent or at least reduce a potential for blowout of the traction projection under repeated loads which may induce heat buildup within it. Also, a wear resistance of the traction projection may be enhanced such that the traction projection wears less rapidly. A system for protecting a track against potential occurrence of blowout is also provided.

Abstract: A high torque dual speed turbine rotor for a lightweight hand held tool for grinding and polishing or for use with a spindle mounted pneumatic machine. The high torque dual speed turbine rotor includes a two-piece shaft with flow control screw disposed within the shaft. The shaft includes a first set of hollow openings, at a first position from one end of the shaft, in fluid communications with a first annular chamber of a rotor. There is also a second set of hollow opening, at a second position from the one end of the shaft, in fluid communications with a second annular chamber of the rotor. The flow control screw moves inside a threaded axial bore of the shaft from an open position inside the axial bore to the closed position corresponding to the second set of hollow openings.

Abstract: Disclosed is a method for measuring etch depth including the following steps: splitting a light beam into a first, and respectively second, incident beam directed towards a first, respectively second, area of a sample exposed to an etching treatment to form a first, and respectively second, reflected beam, recombining the first reflected beam and the second reflected beam to form an interferometric beam; detecting a first, and respectively second, interferometric intensity signal relative to a first, respectively second, polarisation component; calculating a lower envelope function and an upper envelope function of a differential polarimetric interferometry signal; determining an offset function and a normalisation function from the first lower envelope function and the first upper envelope function; and calculating a differential polarimetric interferometry function normalised locally at each time instant.

Abstract: A track system of a vehicle can be monitored (e.g., during operation of the vehicle) to obtain information about the track system which can be used for various purposes, such as, for example, to convey the information about the track system to a user (e.g., an operator of the vehicle) and/or to control the vehicle, for instance, by controlling a speed of the vehicle depending on a state (e.g., a temperature and/or one or more other physical characteristics) of the track system. This may be useful, for example, to gain knowledge about a track of the track system, to help prevent rapid wear or other deterioration of the track of the track system (e.g., blowout), and/or to adapt how fast or slow the vehicle moves in order to protect the track of the track system while permitting the speed of the vehicle to be greater over short periods (e.g., when travelling on or crossing roads or other particular areas).

Abstract: A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10?6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

Abstract: A track for traction of a vehicle, such as an agricultural vehicle, an industrial vehicle (e.g., a construction vehicle), a military vehicle, or another off-road vehicle, is provided. The track comprises a ground-engaging outer surface for engaging the ground and a plurality of traction projections projecting from the ground-engaging outer surface and distributed in a longitudinal direction of the track. The traction projections may be designed to enhance their resistance to deterioration during use. For example, a blowout resistance of each traction projection may be enhanced to prevent or at least reduce a potential for blowout of the traction projection under repeated loads which may induce heat buildup within it. Also, a wear resistance of the traction projection may be enhanced such that the traction projection wears less rapidly. A system for protecting a track against potential occurrence of blowout is also provided.

Abstract: The present invention relates to an electroanalytical instrument for determining by amperometry (eg chronoamperometry) the presence or quantity (eg concentration) of an analyte in an aqueous sample, comprising a sealed housing, an elongate pivotal arm mounted on the sealed housing, wherein the elongate pivotal arm houses a potentiostat, and a pivotal forearm joined pivotally to the elongate pivotal arm, which is connectable to an electrochemical sensor. By flexing the pivotal forearm, the electrochemical sensor may be electrically connected to the potentiostat. By flexing the elongate pivotal arm, the electrochemical sensor is immersed in the aqueous sample in the sealed housing.

Abstract: A hydraulic actuator with a sensor mounted on the actuator cylinder for determining the position of the actuator. The arrangement comprises a hydraulic actuator which includes a cylinder having a bore in which a piston is slidably mounted for movement along the cylinder to extend and retract the hydraulic actuator. The cylinder has a side wall and a cylinder aperture extending through the side wall. A wire actuated encoder is mounted on the external surface of the cylinder, which has a wire which extends through the cylinder aperture and is attached to the piston for determining a stroke position of the piston within the cylinder.

Abstract: Disclosed is a method for acquiring and forming a spectrometry image, including the following steps: a) acquiring an initial structural image of an area of a sample; b) breaking down the initial structural image so as to determine a multi-scale spatial sample of the area of the sample; c) determining a plurality of spectrometry measurement positions in the area of the sample, as a function of the multi-scale spatial sampling determined in step b); d) consecutively, for each spectrometry measurement position determined in step c), positioning the excitation beam and acquiring a spectrometry measurement; and e) reconstructing a spectrometry image point-by-point from the spectrometry measurements acquired in step d).

Abstract: A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10?6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

Abstract: The present invention relates to pharmaceutical agents of formula (I), useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or disorders.

Abstract: Disclosed is a method for measuring etch depth including the following steps: splitting a light beam into a first, and respectively second, incident beam directed towards a first, respectively second, area of a sample exposed to an etching treatment to form a first, and respectively second, reflected beam, recombining the first reflected beam and the second reflected beam to form an interferometric beam; detecting a first, and respectively second, interferometric intensity signal relative to a first, respectively second, polarisation component; calculating a lower envelope function and an upper envelope function of a differential polarimetric interferometry signal; determining an offset function and a normalisation function from the first lower envelope function and the first upper envelope function; and calculating a differential polarimetric interferometry function normalised locally at each time instant.

Abstract: Disclosed is a micro-localisation device defining a system of spatial coordinates for an imaging instrument. The micro-localisation device includes at least one first zone and a second zone, adjacent to each other, each zone extending spatially over an area of macroscopic size, each zone including an elementary cell or a tiling of a plurality of elementary cells extending over the respective area of the zone, each elementary cell of the first, respectively second, zone including an orientation pattern, a positioning pattern and a periodic spatial pattern, configured to be imaged by an imaging instrument and to determine a position and, respectively an orientation of the imaging instrument in the system of spatial coordinates of the micro-localisation device.

Abstract: The present invention provides a photoimageable composition comprising a polyamideimide resin, an aprotic solvent, and one or more nitrogen containing ethylenically unsaturated monomers. By addition of the nitrogen containing ethylenically unsaturated monomer, UV curable acrylates can be added to the composition, and the composition is stable. The compositions of the present invention can produce high resolution images that are flexible, hard, and have excellent resistance.

Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.