Abstract: The present invention provides an antibody or antigen-binding fragment thereof that binds ?v?3 integrin, as well as methods of use in the treatment of diseases and disorders.

Abstract: A system and method for separating polymer components of a multi-component article, such as a shoe, is presented. The described system and method exploits the differences in embrittlement and glass transition temperature of different polymer components of the multi-component article by cryogenically freezing the prepared article and impacting the article such that one polymer component is pulverized without substantially fracturing the remaining portion of the article. The system and method further includes a re-looping capability to maximize separation and recovery of polymer components.

Abstract: A connector (100) for a modular garden bed is 100 described. The connector preferably includes a pair of wings members (1011, 1012) disposed at an angle to one another along a central seam (102). The wing members (1011, 1012) are contoured for complementary engagement with wall members (11) of the garden bed. A plurality of apertures (107) may be provided in the connector (100) for alignment with one or more corresponding apertures disposed within the wall members to permit the insertion of one or more fasteners to secure the connector (100) to the wall members (11).

Abstract: The present invention provides an antibody or antigen-binding fragment thereof that binds ?V?3 integrin, as well as methods of use in the treatment of diseases and disorders.

Abstract: In certain embodiments, this application provides humanized antibodies that bind to the EphB4 protein as well as uses of the antibodies for therapeutic purposes.

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.

Abstract: Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab) are conjugated with one or more zirconium complex (Z) labels through a linker (L) to form cysteine engineered zirconium-labeled antibody conjugates having Formula I: Ab-(L-Z)p??I where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed.

Abstract: A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.

Abstract: Software for editing text and images enables a user to select a portion of an image and read the text on the selected image portion via an OCR function. The software enables the user to apply a mask containing the originally read text, that allows the user to type or paste new text to replace the previously read text in the selected image portion. The software also enables a user to edit images by automatically recognizing the borders of fields and/or columns and the background color. As a result the user can easily modify an image by applying a mask to an image wherein the mask has new data such as different text the identical background color or a different background color or different layout etc. and which may be placed exactly on the recognized borders of the original image.

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.

Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.

Abstract: A system and method for the in-line analysis of protein-containing compositions for protein denaturation. The system and method employ providing a protein-containing composition in a container that can be directly used in an analytical method for evaluating the denaturation of a protein. The container can be directly employed in an analytical technique such as UV spectroscopy, circular dichroism, etc.

Abstract: The present invention provides an antibody or antigen-binding fragment thereof that binds ?V?3 integrin, as well as methods of use in the treatment of diseases and disorders.

Abstract: A lock assembly (1) comprises a rotary latch member (3) rotatable between a first, locking, position and a second, released, position, an actuator (23) for effecting rotation of the rotary latch member, and a rotary-drive mechanism between the actuator (23) and the rotary latch member (3) for transmitting a rotary drive to the rotary latch member. The rotary drive mechanism includes first and second members (3, 5) mounted for rotation about substantially parallel axes and having overlapping peripheral portions with sets of interengaging formations (19A, 20A and 19B, 20B), each set of interengaging formations comprising a recess (19A, 19B) extending radially inwardly from a peripheral portion of one of the first and second members and a post (20A, 20B) projecting in a direction generally parallel to the axes of rotation of the members and engagable in the recess.

Abstract: An initiator for the terminal group of the polymer product of an atom or group radical transfer polymerisation has an activated carboxyl or an amine group which is reacted with an amine or carboxyl (respectively) group containing biologically active compound. The initiator is preferably 4-(3-(2-bromo, 2-methyl-propionate)phenyl)-propionic acid N-hydroxysuccinimide ester or 2-bromo, 2-methyl-propionic acid N-hydroxysuccinimide ester. The monomers preferably comprise a zwitterionic monomer such as 2-methacryloxyethyl-2?-trimethyl ammoniumethyl phosphate inner salt.

Abstract: Software for editing text and images enables a user to select a portion of an image and read the text on the selected image portion via an OCR function. The software enables the user to apply a mask containing the originally read text, that allows the user to type or paste new text to replace the previously read text in the selected image portion. The software also enables a user to edit images by automatically recognizing the borders of fields and/or columns and the background color. As a result, the user can easily modify an image by applying a mask to an image, wherein the mask has new data such as different text, the identical background color or a different background color or different layout, etc. and which may be placed exactly on the recognized borders of the original image.

Abstract: A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.

Abstract: A method for acquiring data to process a financial account is provided which includes receiving a request to process the financial account. The request includes a print stream of data for a client received in a print protocol. The method further includes converting the print stream of data into wire format data, and transmitting the wire format data to a server to process the financial account. A method is provided for processing a financial account which includes receiving a request from a client to process the financial account. The request includes a print stream of data for a client received in a print protocol. The method further includes extracting data elements from the received wire format data, and processing the financial account using the extracted data elements. The receiving includes receiving encrypted wire format data which has been converted from the print stream of data for the client received in a print protocol.

Abstract: Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.

Abstract: The present invention provides a lubricating composition for use in the crankcase of an engine comprising a base oil and one or more additives, wherein the base oil comprises a Fischer-Tropsch derived base oil and wherein the lubricating composition has a kinematic viscosity at 100 C (according to ASTM D 445} of below 5.6 cSt and a Noack volatility (according to ASTM D 5800) of below 15 wt. %.