Patents by Inventor Simone Lederle

Simone Lederle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fermentative production of acetone from renewable resources by means of novel metabolic pathway
    Patent number: 8986961
    Abstract: The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO2, which is characterized in that the coenzyme A is not transferred in process step B to an acceptor molecule. In addition, process step B is surprisingly catalyzed by enzymes of the classes of acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase. A completely novel metabolic pathway is concerned, because the enzymatic hydrolysis of acetoacetyl-CoA without simultaneous transfer of CoA to a receptor molecule has never previously been described for any microbial enzyme.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: March 24, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Stefan Verseck, Steffen Schaffer, Werner Freitag, Friedrich-Georg Schmidt, Matthias Orschel, Gerda Grund, Wilfried Schmidt, Hubert Johannes Bahl, Ralf-Joerg Fischer, Antje May, Peter Duerre, Simone Lederle
  • FERMENTATIVE PRODUCTION OF ACETONE FROM RENEWABLE RESOURCES BY MEANS OF NOVEL METABOLIC PATHWAY
    Publication number: 20100261237
    Abstract: The invention describes a process for preparing acetone starting from acetyl-coenzyme A comprising process steps A. enzymatic conversion of acetyl-CoA into acetoacetyl-CoA B. enzymatic conversion of acetoacetyl-CoA into acetoacetate and CoA and C. decarboxylation of acetoacetate to acetone and CO2, which is characterized in that the coenzyme A is not transferred in process step B to an acceptor molecule. In addition, process step B is surprisingly catalysed by enzymes of the classes of acyl-CoA thioesterase, acyl-CoA synthetase or acyl-CoA thiokinase. A completely novel metabolic pathway is concerned, because the enzymatic hydrolysis of acetoacetyl-CoA without simultaneous transfer of CoA to a receptor molecule has never previously been described for any microbial enzyme.
    Type: Application
    Filed: October 1, 2008
    Publication date: October 14, 2010
    Applicant: EVONIK DEGUSSA Gmbh
    Inventors: Stefan Verseck, Steffen Schaffer, Werner Freitag, Friedrich-Georg Schmidt, Matthias Orschel, Gerda Grund, Wilfried Schmidt, Hubert Johannes Bahl, Ralf-Joerg Fischer, Antje May, Peter Duerre, Simone Lederle