Abstract: A heat exchange device is disclosed herein to be used in conjunction with a standard fireplace. The heat exchange device is made from a continuous tube fabricated into loops that surround the burning fuel. The ambient room air, introduced through an opening for air entry into the tube, is blown through the internal lumen of the tube fabricated into loops, the external surfaces of which are in direct contact with burning fuel and flame. The air passing through the internal lumen of the tube fabricated into loops is heated to a high temperature by the burning fuel and flame.

Abstract: A drug delivery system provides sustained-release delivery of therapeutic biologically active compounds administered epidurally. In the preferred embodiment the biologically active compound is an opioid, which is encapsulated within the non-concentric internal aqueous chambers or bilayers of multivesicular liposomes. The opioid is released over an extended period of time when the liposomes are introduced epidurally as a single dose for sustained analgesia.

Abstract: Disclosed are multivesicular liposomes containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated rate of the biologically active substance in contrast to the previous art.

Abstract: The invention is a bicycling device and method of use thereof, whereby muscle power can be more efficiently transferred from the cyclist's upper-extremities (arms) to the conventional footpedals via the cyclist's lower-extremities (legs) without need of mechanical contrivance and associated drain on fractional human-power capability. The device is attached proximally to the knee region as a method by which a cyclist may obtain a firm manual handhold, whereby the cyclist can grasp the device with his hand and proceed to exert appropriate downward-thrust or upward-thrust (during up-stroke using shoe/pedal-cleats) supplied from upper-extremities according to the regular cyclic rotation of the associated footpedal. Since upper extremity thrusting is applied directly through mechanism of the cyclist's own lower extremities, the need for manufactured mechanical contrivance and its associated weight penalty has been averted.

Abstract: A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.

Abstract: Liposomes containing cyclodextrin in the encapsulated aqueous phase are useful for encapsulation of biologically active substances, especially those which are hydrophilic. The encapsulated cyclodextrin facilitates a slow, controlled release of pharmacologic compounds from the liposomes. The novel methods of the present invention allow the treatment of a variety of pathophysiological states by administering the cyclodextrin-containing liposomes encapsulating the pharmacologic compounds. The present invention also provides a novel method of extending the half life of a pharmacologic compound in an animal.

Abstract: The disclosure sets forth a roll-bar structure for a conventional motorcycle configured to provide both forward and aftward protection as well as side protection. The basic embodiment comprises dual spaced apart longitudinal tubular, metal members of inverted U-shaped design, the lower terminuses of which are oppositely fixed to both the front and rear of the motorcycle mainframe. Other embodiments include an articulated rear-half assembly which can move fore and aft according to the position of the motorcyclist, a longitudinal roll-bar configuration appearing substantially H-shaped in side view, and a combination of an inverted U-shaped roll-bar and an H-shaped roll-bar.

Abstract: Disclosed are multivesicular liposomes containing biologically active substances, the multivesicular liposomes having defined size distribution, adjustable average size, adjustable internal chamber size and number, and a modulated rate of the biologically active substance in contrast to the previous art.

Abstract: A method for ameliorating a neurological disorder in a human by administration to the cerebrospinal fluid (CSF) of a therapeutic agent in a dispersion system which allows the therapeutic agent to persist in the cerebro-ventricular space.

Abstract: Disclosed are heterovesicular liposomes containing substances of different biologically active compositions each encapsulated in separate chambers of the liposomes, having defined size distribution, adjustable average size, adjustable internal chamber size and number, methods of making them, and treatment of patients with them.

Abstract: A method for ameliorating a neurological disorder in a human by administration to the cerebrospinal fluid (CSF) of a therapeutic agent in a dispersion system which allows the therapeutic agent to persist in the cerebro-ventricular space.

Abstract: Disclosed are heterovesicular liposomes containing substances of different biologically active compositions each encapsulated in separate chambers of the liposomes, having defined size distribution, adjustable average size, adjustable internal chamber size and number, methods of making them, and treatment of patients with them.

Abstract: An improved, rapid method for preparing substantially spherical multilamellar liposomes of a defined and adjustable size within the range of 2 to 100 micrometers, suitable for encapsulation and targeting of drugs.