Abstract: The present application relates to crystalline form 04, crystalline form 06, crystalline form D-1, and crystalline form D-2 of an antidepressant drug SAGE-217 and a preparation method therefor and a pharmaceutical composition containing same. The crystalline form 04 has an XRPD pattern with characteristic peaks at 2theta values of 11.6±0.2°, 13.5±0.2°, 16.2±0.2°, 16.5±0.2°, and 23.2±0.2°; the crystalline form 06 has an XRPD pattern with characteristic peaks at 2theta values of 8.7±0.2°, 10.0±0.2°, 13.2±0.2°, 15.0±0.2°, 15.8±0.2°, and 17.3±0.2°; the crystalline form D-1 has an XRPD pattern with characteristic peaks at 2theta values of 7.2±0.2°, 8.6±0.2°, 13.3±0.2°, 19.6±0.2°, and 23.0±0.2°; and the crystalline form D-2 has an XRPD pattern with characteristic peaks at 2theta values of 7.3±0.2°, 8.6±0.2°, 13.4±0.2°, 19.7±0.2°, and 23.3±0.2°. The novel crystalline forms provided by the present application have good stability, and provide more choices for drug development.

Abstract: A perforating device includes a release sub, a rotating segment, a first centralizer, a braking segment, a casing collar locator, a traction mechanism, a second centralizer, a flex joint, a power supply segment, a shock absorber, a perforator, and a tail segment, which are in threaded connection sequentially to each other. The first joint assembly includes a first joint, a guide key, a connecting sleeve including a locking groove, a second joint, and an outer pipe; the first joint of the first joint assembly is in threaded connection to the cable bridle, and the second joint is in threaded connection to the outer pipe. The connecting sleeve is disposed inside the outer pipe and is connected to the first joint through the guide key. The second joint assembly includes a plurality of locking claws, a third joint, and a head.

Abstract: A perforating device includes a release sub, a rotating segment, a first centralizer, a braking segment, a casing collar locator, a traction mechanism, a second centralizer, a flex joint, a power supply segment, a shock absorber, a perforator, and a tail segment, which are in threaded connection sequentially to each other. The first joint assembly includes a first joint, a guide key, a connecting sleeve including a locking groove, a second joint, and an outer pipe; the first joint of the first joint assembly is in threaded connection to the cable bridle, and the second joint is in threaded connection to the outer pipe. The connecting sleeve is disposed inside the outer pipe and is connected to the first joint through the guide key. The second joint assembly includes a plurality of locking claws, a third joint, and a head.

Abstract: A mechanically rotating intravascular ultrasound probe relates to the technical field of medical devices, and aims to provide a forward-looking mechanically rotating intravascular ultrasound probe having a small volume, a high image resolution and good imaging stability. The intravascular ultrasound probe includes a catheter, an ultrasonic transducer disposed at a front end of a cavity of the catheter and a driving apparatus that drives the ultrasonic transducer to rotate mechanically. The driving apparatus is a micro motor disposed in the cavity of the catheter, including a rotor and a stator.

Abstract: Ultrasound radiation using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location. The detection location can be at one point at a time for imaging two-dimensional or three-dimensional tissue nonlinearities and shear wave properties including nonlinear magnitude variations, nonlinear phase variations, nonlinear coefficients, and viscoelasticity.

Abstract: A control processing system and an imaging method for a subcutaneous vein developing device are provided. The control processing system includes a processor subsystem and a programmable logic subsystem. The processor subsystem and the programmable logic subsystem are interconnected via a high-bandwidth Advanced eXtensible Interface (AXI) bus. The control processing system is in signal communication with a visible light source driving circuit, a near infrared light source driving circuit, a projection imaging element driving circuit, a near infrared imaging element driving circuit, a display screen driving circuit, and a user control interface. For a subcutaneous vein developing imaging application and imaging characteristics thereof, a control processing system architecture of a subcutaneous vein developing system is designed and is implemented in a manner of combining software and hardware.

Abstract: Methods and apparatus measuring tissue nonlinear shear wave property are disclosed. When tissue shear responses are different to ultrasound radiation forces generated by pulses having different shapes, its nonlinear effect can be used to estimate tissue property at single location without measurements of group velocities or phase velocities. Ultrasound radiation force using a single tone burst pulse is applied to a selected location in a tissue region. The induced shear wave is detected in the region and its spectral distribution is calculated and analyzed. This detection may be repeated with other excitation pulses having different widths or different shapes at the same location. The spectral analysis of the detected shear wave is performed according to a nonlinear shear model for solving nonlinearity and viscoelasticity of the tissue at a single location in a tissue region.

Abstract: A mechanically rotating intravascular ultrasound probe relates to the technical field of medical devices, and aims to provide a forward-looking mechanically rotating intravascular ultrasound probe having a small volume, a high image resolution and good imaging stability. The intravascular ultrasound probe includes a catheter, an ultrasonic transducer disposed at a front end of a cavity of the catheter and a driving apparatus that drives the ultrasonic transducer to rotate mechanically. The driving apparatus is a micro motor disposed in the cavity of the catheter, including a rotor and a stator.