Patents by Inventor Sivaram Pillarisetti

Sivaram Pillarisetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the treatment of inflammatory diseases
    Publication number: 20020077293
    Abstract: The present invention is directed to compositions and methods for treating inflammatory diseases comprising administration of compositions that effect glycogen synthase kinase 3&bgr; (GSK-3&bgr;) protein or gene. The present invention also comprises methods and compositions for the identification of compounds or therapeutic agents which modulate the activity of the protein. The present invention provides compositions for and methods off treatment of biological conditions including, but not limited to, type I and type II diabetic induced vasculopathy, other vasculopathies, asthma and inflammation-induced diseases such as atherosclerosis and cell proliferation.
    Type: Application
    Filed: October 2, 2001
    Publication date: June 20, 2002
    Inventors: Shianlen Cahoon, Sivaram Pillarisetti, Uday Saxena, Angela Vines
  • Methods and compositions for glycosidase assays
    Publication number: 20020064806
    Abstract: The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively determining the amount of glycosidase activity in a sample. The present invention also provides methods for the diagnosis of metastatic and inflammatory processes in vitro and in vivo. The present invention further provides compositions and methods for high throughput assays for identifying compounds that effect glycosidase activity.
    Type: Application
    Filed: September 14, 2001
    Publication date: May 30, 2002
    Inventors: Sivaram Pillarisetti, Uday Saxena, Dongyan Wang
  • Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
    Patent number: 6156315
    Abstract: This invention also provides a method of treating atherosclerosis in a subject, comprising administering to the subject an effective amount of a substance capable of binding to the amino-terminal region of apolipoprotein B, thereby treating the atherosclerosis. This invention also provides a method for inhibiting the binding of low density lipoprotein to blood vessel matrix in a subject, comprising administering to the subject an effective amount of a substance capable of competing with the amino-terminal region of apolipoprotein B for binding to blood vessel matrix, thereby inhibiting the binding of low density lipoprotein to blood vessel matrix. This invention also provides a method for identifying a compound capable of ameliorating atherosclerosis. Additionally, this invention provides a kit for inhibiting the binding of low density lipoprotein to blood vessel matrix, wherein the kit comprises a substance capable of binding to the amino-terminal region of apolipoprotein B.
    Type: Grant
    Filed: November 7, 1997
    Date of Patent: December 5, 2000
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Ira J. Goldberg, Sivaram Pillarisetti