Patents by Inventor Siyuan Tan

Siyuan Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20180010152
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: September 20, 2017
    Publication date: January 11, 2018
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • DNA-binding proteins and uses thereof
    Patent number: 9783827
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: October 10, 2017
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • OPTIMIZED FACTOR IX GENE
    Publication number: 20170260516
    Abstract: The present invention provides codon optimized Factor IX sequences, vectors and host cells comprising codon optimized Factor IX sequences, polypeptides encoded by codon optimized Factor IX sequences, and methods of producing such polypeptides. The present invention also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized Factor IX nucleic acid sequence or the polypeptide encoded thereby.
    Type: Application
    Filed: June 30, 2015
    Publication date: September 14, 2017
    Applicant: Biogen MA Inc.
    Inventors: Siyuan TAN, Robert T. PETERS, Tongyao LIU
  • METHODS AND COMPOSITIONS FOR INCREASING RNA ACTIVITY IN A CELL
    Publication number: 20170137845
    Abstract: Disclosed herein are methods and compositions for increasing RNA activity in a cell.
    Type: Application
    Filed: November 9, 2016
    Publication date: May 18, 2017
    Inventors: Siyuan Tan, Dale Ando, Andreas Reik, Lihong Li, Madhusudan V. Peshwa, Haiyan Jiang
  • NOVEL DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20170016030
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: October 3, 2016
    Publication date: January 19, 2017
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • DNA-binding proteins and uses thereof
    Patent number: 9493750
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 15, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Modified DNA-binding proteins and uses thereof
    Patent number: 9458205
    Abstract: Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: October 4, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Anti-GPIIB/IIIA Antibodies or Uses Thereof
    Publication number: 20160115234
    Abstract: The present invention provides antibodies and antigen-binding molecules thereof which specifically bind the ? and/or ? subunits of the non-active form of the GPIIb/IIIIa receptor. The antibodies and antigen-binding molecules can be genetically fused and/or conjugated to heterologous moieties and used, for example, as targeting moieties. The invention also includes methods for screening for these antibodies, as well as methods of making and methods of using chimeric molecules derived from the antibodies.
    Type: Application
    Filed: May 23, 2014
    Publication date: April 28, 2016
    Inventors: Joe Salas, Siyuan Tan, Robert Peters
  • DNA-binding proteins and uses thereof
    Patent number: 9322005
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: April 26, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Optimized Factor VIII Gene
    Publication number: 20150361158
    Abstract: The present invention provides codon optimized Factor VIII sequences, vectors and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides.
    Type: Application
    Filed: February 14, 2014
    Publication date: December 17, 2015
    Applicant: Biogen MA Inc.
    Inventors: Siyuan TAN, Robert T. PETERS
  • SOYBEAN EVENT 127 AND METHODS RELATED THERETO
    Publication number: 20150250129
    Abstract: Compositions and methods related to transgenic AHAS-inhibiting herbicide resistant soybean plants are provided. Event 127 soybean plants having a mutated AHAS coding sequence which imparts tolerance to an AHAS-inhibiting herbicide are provided. The event 127 soybean plants having the event 127 nucleic acid molecule at the identified chromosomal location comprises genomic/transgene junctions having at least the nucleic acid sequence of SEQ ID NO:5 and/or 6. The characterization of the genomic insertion site of the event 127 provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the event 127 soybean plants are provided.
    Type: Application
    Filed: April 6, 2015
    Publication date: September 10, 2015
    Inventors: Dale CARLSON, Francisco Jose Lima ARAGAO, Carlos Alberto Arrabal ARIAS, Luiz LOUZANO, Bruce M. LUZZI, Tim MALEFYT, Elibio Leopoldo Rech FILHO, Siyuan TAN, Adolfo ULBRICH, Tadashi YOTSUMOTO, Ute LINEMANN
  • Soybean event 127 and methods related thereto
    Patent number: 9024114
    Abstract: Compositions and methods related to transgenic AHAS-inhibiting herbicide resistant soybean plants are provided. Event 127 soybean plants having a mutated AHAS coding sequence which imparts tolerance to an AHAS-inhibiting herbicide are provided. The event 127 soybean plants having the event 127 nucleic acid molecule at the identified chromosomal location may comprise genomic/transgene junctions having at least the nucleic acid sequence of SEQ ID NO: 5 and/or 6. The characterization of the genomic insertion site of the event 127 provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the event 127 soybean plants are provided.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: May 5, 2015
    Assignees: Empresa Brasileira de Pesquisa Agropecuaria—Embrapa, BASF Agrochemical Products B.V.
    Inventors: Dale Carlson, Francisco Jose Lima Aragao, Carlos Alberto Arrabal Arias, Luiz Louzano, Bruce M. Luzzi, Tim Malefyt, Elibio Leopoldo Rech Filho, Siyuan Tan, Adolfo Ulbrich, Tadashi Yotsumoto, Ute Linemann
  • DNA-binding proteins and uses thereof
    Patent number: 8912138
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: December 16, 2014
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • NOVEL DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20140134723
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: October 28, 2013
    Publication date: May 15, 2014
    Applicant: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • NOVEL DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20140134741
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: October 28, 2013
    Publication date: May 15, 2014
    Applicant: Sangamo Biosciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • NOVEL DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20140134740
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: October 28, 2013
    Publication date: May 15, 2014
    Applicant: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • DNA-binding proteins and uses thereof
    Patent number: 8586526
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: November 19, 2013
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Methods and compositions for treating neuropathies
    Patent number: 8551945
    Abstract: Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: October 8, 2013
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Carolyn Dent, Josee Laganiere, Xiangdong Meng, David Paschon, Siyuan Tan, Lei Zhang, Steve H. Zhang
  • Soybean Event 127 and Methods Related Thereto
    Publication number: 20120117676
    Abstract: Compositions and methods related to transgenic AHAS-inhibiting herbicide resistant soybean plants are provided. Event 127 soybean plants having a mutated AHAS coding sequence which imparts tolerance to an AHAS-inhibiting herbicide are provided. The event 127 soybean plants having the event 127 nucleic acid molecule at the identified chromosomal location may comprise genomic/transgene junctions having at least the nucleic acid sequence of SEQ ID NO: 5 and/or 6. The characterization of the genomic insertion site of the event 127 provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the event 127 soybean plants are provided.
    Type: Application
    Filed: January 6, 2010
    Publication date: May 10, 2012
    Inventors: Dale Carlson, Francisco Jose Lima Aragao, Carlos Alberto Arrabal Arias, Luiz Louzano, Bruce M. Luzzi, Tim Malefyt, Elibio Leopoldo Rech Filho, Siyuan Tan, Adolfo Ulbrich, Tadashi Yotsumoto, Ute Linemann
  • Novel DNA-binding proteins and uses thereof
    Publication number: 20110301073
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: May 17, 2011
    Publication date: December 8, 2011
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang