Patents by Inventor Solvej Siedler
Solvej Siedler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11875298Abstract: An NADP(H) nanosensor has i) a nucleic acid sequence to which a regulator is capable of binding, wherein the oxidation state of the regulator depends on the NADP(H) availability; ii) a promoter sequence following the nucleic acid sequence i), to which an RNA polymerase is capable of binding, wherein the affinity of the RNA polymerase for the promoter sequence is influenced by the oxidation state of the regulator; iii) a nucleic acid sequence which is under the control of the promoter sequence ii) and which codes for an autofluorescent protein. The present invention also relates to a cell, a method for isolating genes which code for NADP(H)-dependent enzymes, and the use of an NADP(H) nanosensor.Type: GrantFiled: July 22, 2019Date of Patent: January 16, 2024Assignee: Forschungszentrum Julich GMBHInventors: Solvej Siedler, Georg Schendzielorz, Stephan Binder, Lothar Eggeling, Stephanie Bringer-Meyer, Michael Bott
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Publication number: 20230301317Abstract: The present invention provides a method of controlling growth of yeasts, in particular robust yeasts, by applying Bacillus substilis. More specifically, the present invention provides uses of Bacillus substilis to inhibit or delay growth of yeast like Yarrowia lipolytica by reducing the free iron concentration in a food product which is preferably a fermented food product. Preferably the Bacillus substilis is applied at a concentration of 104 to 109 CFU/ml, preferably 106 to 108 CFU/ml, most preferably 107 CFU/ml.Type: ApplicationFiled: March 22, 2023Publication date: September 28, 2023Inventors: Solvej Siedler, Susanne Bidstrup, Rute Neves
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Publication number: 20230297924Abstract: The present invention relates to an NADP(H) nanosensor comprising i) a nucleic acid sequence to which a regulator is capable of binding, wherein the oxidation state of the regulator depends on the NADP(H) availability; ii) a promoter sequence following the nucleic acid sequence i), to which an RNA polymerase is capable of binding, wherein the affinity of the RNA polymerase for the promoter sequence is influenced by the oxidation state of the regulator; iii) a nucleic acid sequence which is under the control of the promoter sequence ii) and which codes for an autofluorescent protein. The present invention also relates to a cell, a method for isolating genes which code for NADP(H)-dependent enzymes, and the use of an NADP(H) nanosensor.Type: ApplicationFiled: July 22, 2019Publication date: September 21, 2023Inventors: Solvej SIEDLER, Georg SCHENDZIELORZ, Stephan BINDER, Lothar EGGELING, Stephanie BRINGER-MEYER, Michael BOTT
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Publication number: 20230292780Abstract: The present invention is in the field of food technology. The present invention provides methods of controlling growth of Listeria by limiting their access to manganese More specifically, the present invention provides a method of inhibiting or delaying growth of Listeria by reducing the manganese concentration in a food product which is preferably a dairy product. The invention also provides manganese scavengers and uses thereof to inhibit or delay Listeria growth.Type: ApplicationFiled: April 16, 2021Publication date: September 21, 2023Applicant: Chr. Hansen A/SInventors: Lieke VAN GIJTENBEEK, Solvej SIEDLER, Helle Skov GULDAGER, Louise Essendrup STEFFENSEN
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Patent number: 11707070Abstract: The present invention provides a method of controlling growth of unwanted microorganisms by limiting their access to manganese. More specifically, the present invention provides a method of inhibiting or delaying growth of yeast and mold by reducing the manganese concentration in a product which is preferably a food product. The invention also provides manganese scavengers and uses thereof to inhibit or delay fungal growth.Type: GrantFiled: April 17, 2019Date of Patent: July 25, 2023Assignee: Chr. Hansen A/SInventors: Solvej Siedler, Martin Holm Rau, Stina Dissing Aunsbjerg Nielsen
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Publication number: 20230189831Abstract: The present invention is in the field of dairy technology. It relates to methods for producing fermented milk products, characterized the bacterium Lactobacillus rhamnosus DSM 33515 or mutants obtainable therefrom is used. Lactobacillus rhamnosus bacteria DSM 33515 has low post-acidification in fermented milk products and can provide antimicrobial effects. The invention also provides Lactobacillus rhamnosus DSM 33515 or mutants obtainable therefrom as well as related compositions.Type: ApplicationFiled: May 20, 2021Publication date: June 22, 2023Applicant: Chr. Hansen A/SInventors: Cecilie Lykke Marvig Nielsen, Susanne Bidstrup, Vera Kuzina Poulsen, Solvej Siedler, Kim Ib Soerensen
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Patent number: 11306331Abstract: The present invention generally relates to the field of biotechnology as it applies to the production of hydroxycinnamic acids using polypeptides having tyrosine ammonia lyase activity. More particularly, the present invention pertains to polypeptides having tyrosine ammonia lyase activity and high substrate specificity towards tyrosine, which makes them particularly suitable in the production of p-coumaric acid and other hydroxycinnamic acids. The present invention thus provides processes for the production of p-coumaric acid and other hydroxycinnamic acids employing these polypeptides as well as recombinant host cells expressing same.Type: GrantFiled: July 24, 2020Date of Patent: April 19, 2022Assignee: CYSBIO APSInventors: Christian Bille Jendresen, Solvej Siedler, Steen Gustav Stahlhut, Alex Toftgaard Nielsen
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Publication number: 20210169086Abstract: The present invention provides a method of controlling growth of unwanted microorganisms by limiting their access to manganese. More specifically, the present invention provides a method of inhibiting or delaying growth of yeast and mold by reducing the manganese concentration in a product which is preferably a food product. The invention also provides manganese scavengers and uses thereof to inhibit or delay fungal growth. The manganese scavenger may be a bacterial cell, specifically a lactic acid bacterial cell, more specifically Lactobacillus rhamnosus alone or in combination with Lactobacillus paracasei.Type: ApplicationFiled: April 17, 2019Publication date: June 10, 2021Applicant: Chr. Hansen A/SInventors: Solvej SIEDLER, Martin Holm RAU, Stina Dissing Aunsbjerg NIELSEN
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Publication number: 20200399665Abstract: The present invention generally relates to the field of biotechnology as it applies to the production of hydroxycinnamic acids using polypeptides having tyrosine ammonia lyase activity. More particularly, the present invention pertains to polypeptides having tyrosine ammonia lyase activity and high substrate specificity towards tyrosine, which makes them particularly suitable in the production of p-coumaric acid and other hydroxycinnamic acids. The present invention thus provides processes for the production of p-coumaric acid and other hydroxycinnamic acids employing these polypeptides as well as recombinant host cells expressing same.Type: ApplicationFiled: July 24, 2020Publication date: December 24, 2020Inventors: Christian Bille JENDRESEN, Solvej SIEDLER, Steen Gustav STAHLHUT, Alex Toftgaard NIELSEN
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Patent number: 10752923Abstract: The present invention generally relates to the field of biotechnology as it applies to the production of hydroxycinnamic acids using polypeptides having tyrosine ammonia lyase activity. More particularly, the present invention pertains to polypeptides having tyrosine ammonia lyase activity and high substrate specificity towards tyrosine, which makes them particularly suitable in the production of p-coumaric acid and other hydroxycinnamic acids. The present invention thus provides processes for the production of p-coumaric acid and other hydroxycinnamic acids employing these polypeptides as well as recombinant host cells expressing same.Type: GrantFiled: July 14, 2015Date of Patent: August 25, 2020Assignee: CYSBIO APSInventors: Christian Bille Jendresen, Solvej Siedler, Steen Gustav Stahlhut, Alex Toftgaard Nielsen
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Publication number: 20200027049Abstract: The present invention relates to an NADP(H) nanosensor comprising i) a nucleic acid sequence to which a regulator is capable of binding, wherein the oxidation state of the regulator depends on the NADP(H) availability; ii) a promoter sequence following the nucleic acid sequence i), to which an RNA polymerase is capable of binding, wherein the affinity of the RNA polymerase for the promoter sequence is influenced by the oxidation state of the regulator; iii) a nucleic acid sequence which is under the control of the promoter sequence ii) and which codes for an autofluorescent protein. The present invention also relates to a cell, a method for isolating genes which code for NADP(H)-dependent enzymes, and the use of an NADP(H) nanosensor.Type: ApplicationFiled: July 22, 2019Publication date: January 23, 2020Inventors: Solvej SIEDLER, Georg SCHENDZIELORZ, Stephan BINDER, Lothar EGGELING, Stephanie BRINGER-MEYER, Michael BOTT
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Patent number: 10385349Abstract: The present invention relates to an NADP(H) nanosensor comprising i) a nucleic acid sequence to which a regulator is capable of binding, wherein the oxidation state of the regulator depends on the NADP(H) availability; ii) a promoter sequence following the nucleic acid sequence i), to which an RNA polymerase is capable of binding, wherein the affinity of the RNA polymerase for the promoter sequence is influenced by the oxidation state of the regulator; iii) a nucleic acid sequence which is under the control of the promoter sequence ii) and which codes for an autofluorescent protein. The present invention also relates to a cell, a method for isolating genes which code for NADP(H)-dependent enzymes, and the use of an NADP(H) nanosensor.Type: GrantFiled: August 16, 2013Date of Patent: August 20, 2019Assignee: Forschungszentrum Julich GmbHInventors: Solvej Siedler, Georg Schendzielorz, Stephan Binder, Lothar Eggeling, Stephanie Bringer-Meyer, Michael Bott
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Publication number: 20170166936Abstract: The present invention generally relates to the field of biotechnology as it applies to the production of hydroxycinnamic acids using polypeptides having tyrosine ammonia lyase activity. More particularly, the present invention pertains to polypeptides having tyrosine ammonia lyase activity and high substrate specificity towards tyrosine, which makes them particularly suitable in the production of p-coumaric acid and other hydroxycinnamic acids. The present invention thus provides processes for the production of p-coumaric acid and other hydroxycinnamic acids employing these polypeptides as well as recombinant host cells expressing same.Type: ApplicationFiled: July 14, 2015Publication date: June 15, 2017Applicant: Danmarks Tekniske UniversitetInventors: Christian Bille Jendresen, Solvej Siedler, Steen Gustav Stahlhut, Alex Toftgaard Nielsen
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Publication number: 20150299715Abstract: The present invention relates to an NADP(H) nanosensor comprising i) a nucleic acid sequence to which a regulator is capable of binding, wherein the oxidation state of the regulator depends on the NADP(H) availability; ii) a promoter sequence following the nucleic acid sequence i), to which an RNA polymerase is capable of binding, wherein the affinity of the RNA polymerase for the promoter sequence is influenced by the oxidation state of the regulator; iii) a nucleic acid sequence which is under the control of the promoter sequence ii) and which codes for an autofluorescent protein. The present invention also relates to a cell, a method for isolating genes which code for NADP(H)-dependent enzymes, and the use of an NADP(H) nanosensor.Type: ApplicationFiled: August 16, 2013Publication date: October 22, 2015Inventors: Solvej Siedler, Georg Schendzielorz, Stephan Binder, Lothar Eggeling, Stephanie Bringer-Meyer, Michael Bott