Abstract: A system for detecting an occlusion in a fluid line is disclosed which can detect occlusions in the upstream or container side of a disposable cassette containing a fluid pump therein. The cassette includes a piston-type pump with inlet and outlet valves, and is for installation onto and use with a main pump unit including motors for driving the pump and valves contained in each cassette. The system utilizes control circuitry to monitor the intake stroke of the pump in the cassette, to detect an upstream occlusion in the fluid line leading to the pump, and to provide an alarm in the event of a container-side occlusion.