Abstract: The present application provides a recombinant fusion protein containing an anti-CD24 antibody or an antibody fragment thereof, with at least one paratope of the anti-CD24 antibody or antibody fragment thereof linked via a linker to an extracellular Ig-like domain of a signal-regulatory protein (SIRP) at N-terminus of a heavy chain or a light chain constituting that paratope, wherein the recombinant fusion protein can bind to CD47, CD24 and FcR simultaneously. The present application also provides a nucleic acid molecule encoding the recombinant fusion protein, an expression vector containing the nucleic acid molecule, a method for producing the recombinant fusion protein and a method for treating a disease associated with over expression of CD47 and/or CD24 using the recombinant fusion protein.

Abstract: The present disclosure provides a method for evaluating an electronic device. The method comprises determining, with an acoustic tube, a value of a first parameter, the value of the first parameter being indicative of the acoustic impedance of a reference termination. The method further comprises determining, with the acoustic tube, a value of a second parameter, the value of the second parameter being indicative of the acoustic impedance of the reference termination, when occluded by the electronic device. The method then comprises calculating a value of a third parameter, the value of the third parameter being indicative of the acoustic impedance of the electronic device, based on the value of the first parameter and the value of the second parameter.

Abstract: A novel injectable human amniotic membrane (hAM) matrix to enhance cardiac repair and/or regeneration following myocardial injury (MI) and wound healing has been developed. The invention disclosed herein provides human amniotic membranes isolated from human placenta and engineered to be a thermo-responsible, injectable gel at temperature ranges that fall within body temperature. The ultrasound-guided injection of hAM matrix into a rodent model of myocardial infarction significantly improved cardiac contractility, as measured by ejection fraction (EF), and decreased fibrosis. The disclosure provided herein demonstrates the specific engineering injectable hAM matrices and their efficacy in attenuating degenerative changes in cardiac function following MI, which has broad applications in wound healing and tissue regeneration.

Abstract: A computer-implemented method for generating spatial audio with uniform reverberation in a real-time communication session is performed by a real-time communication software application running on an electronic communication device. The method includes removing the reverberation of recorded speech signals from far-end participants by the dereverberation approach, rendering the direct sound parts by filtering the output signals by head-related transfer functions of desired directions, generating reverberant sound parts by convolving the output signals from with uniform room impulse responses or an artificial reverberator, combining direct and reverberant sound components to generate spatialized speech signals. When speakers and listeners are located in two virtual conference rooms, the reverberation of the two rooms are coupled. The reverberant sound parts are then generated by convolving the output signals and coupled RIRs from the two rooms.

Abstract: A display panel, a display device, and a vehicle monitoring device are provided. The display panel includes a display area and a light-transmitting area adjacent to the display area. The display panel includes a first base and a second base opposite to each other and a liquid crystal layer disposed between the first base and the second base. The display panel includes a planarization layer, a passivation layer, and an electrode layer disposed on a side of the first base close to the second base. Further, an orthographic projection of the electrode layer on the first base is outside the light-transmitting area.

Abstract: A content extraction method includes in the case that the target interface is displayed on the screen of the electronic device, if the target touch input of the user on the screen is received, obtaining target coordinates, where the target coordinates are coordinates of the selected target position in the target interface, and the target position corresponds to the touch position of the target touch input on the screen; obtaining node information of at least one node in the target interface, where the node information of a node includes node coordinates of the node and the content indicated by the node; determining a target node according to the target coordinates and the node information of the at least one node, where the node coordinates of the target node match the target coordinates; and extracting the target content included in the target interface and indicated by the target node.

Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

Abstract: The unmanned sprayer apparatus according to the present invention includes a vehicle body of the unmanned sprayer apparatus that moves automatically in a greenhouse including a first rail and a second rail installed on flat land, and a controller configured to control the vehicle body to be switched and moved between the first rail and the second rail while the vehicle body travels on the flat land. The controller is configured to travel the vehicle body rearward on the first rail and when a front end of the first rail is detected, stop the vehicle body, to move the vehicle body laterally toward the second rail and when a front end of the second rail is detected, stop the vehicle body, and to align the vehicle body in a direction of the second rail and then dock the vehicle body to the second rail.

Abstract: A method and an apparatus for recognition a position and generating a path for autonomous driving of a mobile robot in an orchard environment are provided. The method converts three-dimensional (3D) point cloud data for the orchard environment into a 2D grid map, obtains a position of the mobile robot by performing local scan matching and global scan matching on the 2D grid map, and extracts a tree from the 2D grid map based on occupancy of each grid of the 2D grid map. Then, an effective line based on center points of extracted trees is obtained, a destination based on the obtained effective line is generated, and a driving path according to the generated destination and the position of the mobile robot is generated.

Abstract: Techniques are described with regard to managing transaction size during a database replication process. An associated computer-implemented method includes identifying each of at least one transaction associated with at least one source database stored in a replication capture memory, identifying at least one potential excessive memory transaction by applying, via at least one machine learning pattern detection model, pattern detection to each of the at least one transaction stored in the replication capture memory, and constructing at least one compact data unit associated with each of the at least one potential excessive memory transaction. The computer-implemented method further includes facilitating compact data unit transmission to a replication apply server system in order to replicate the at least one compact data unit associated with each of the at least one potential excessive memory transaction to at least one target database via a replication apply server application.

Abstract: Cellular reprogramming and gene editing represent major advancements in biology, and has wide applications in regenerative medicine, disease therapy and drug screening. However, low and variable efficiencies have created significant roadblocks to the full application of these technologies. The invention disclosed herein overcomes these roadblocks by providing optimized methods and systems that are useful in a variety of cellular engineering and gene editing methodologies, including for example methods designed to enhance the reprogramming of somatic cells into neural cells or pluripotent cells.

Abstract: A method for a self-adaptive service function chain mapping based on a deep reinforcement learning, comprising: establishing an SFC mapping model, dividing an SFC mapping process into a three-layer structure, and representing the structure with abstract parameters; building an SFCR mapping learning neural network, and mapping the abstract parameters to a state, an action and a reward value in the SFCR mapping learning neural network; establishing an empirical playback pool and updating network parameters; summarizing request rates and utilization rates of different VNFs, a number of currently deployed VNFs and a number of unactivated VNFs based on data in the empirical playback pool; and designing a VNF redeployment strategy, and redeploying the VNFs according to the summarized data. The method has good self-adaptability, and can improve the effective service cost rate and the request mapping rate for processing service requests from users in different time periods.

Abstract: An audio controller for an active noise reduction, ANR, reduces an ambient noise signal. The audio controller includes processing circuitry configured to provide a fixed ANR filter configured to generate a first noise reduction signal. Moreover, the processing circuitry is further configured to provide an adaptive ANR filter. The adaptive ANR filter includes one or more adjustable filter coefficients for adapting the adaptive ANR filter and the adaptive ANR filter is configured to generate a second noise reduction signal. The processing circuitry is further configured to generate a total noise reduction signal as an adjustable weighted linear combination of the first noise reduction signal and the second noise reduction signal.

Abstract: Disclosed are a cloud safety computing method, a device and a storage medium based on cloud fault-tolerant technology. The cloud safety computing method includes following steps: S1, adopting a one-master multiple-slave fault-tolerant architecture for management nodes, and using KeepAlived and Haproxy to realize a liveness self-check of the management nodes and a load balancing of user requests, and S2, adopting a dynamic redundancy fault-tolerant safety design for service nodes to maintain a life cycle of application microservices, and giving feedback on liveness information to the management nodes in real time through heartbeat by the service nodes, where the application microservices report the life cycle to the management nodes based on a probe mechanism, and the application microservices exchange input and output information through redundancy voting.

Abstract: The present invention relates to a benzylamine derivative, a preparation method therefor and use thereof, and in particular, to a benzylamine derivative as represented by general formula (I), or a pharmaceutically acceptable stereoisomer, salt, solvate or prodrug thereof, which has a strong binding capability with human PD-L1, can obviously inhibit the interaction of PD-1/PD-L1, and has significant anti-tumor efficacy in vivo. Therefore, the present invention also relates to a preparation method for the benzylamine derivative and use thereof in preparing a drug for treating PD-1/PD-L1-related diseases.

Abstract: A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including a first moiety including at least one group selected for ionic interaction with a second therapeutic agent, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer. The first moiety is attached via a labile bond and is released in vivo from the polymer to provide a biologically or therapeutically active form of a first therapeutic compounds.

Abstract: The present invention relates to an application of an artemisinin compound in treatment of coronavirus infection. Specifically, the present invention provides an application of the compound, and a stereoisomer, a pharmaceutically acceptable salt, a solvate or a hydrate thereof in preparation of medicines. The medicines are used for treating diseases or infection caused by coronavirus (preferably SARS-CoV-2), and the compound is selected from one or more of artemisinin, arteether, artemether, artemisia ketone, dihydroartemisinin, artesunate, arteannuin B, and artemisinic acid.

Abstract: A therapeutic microporous hydrogel scaffold for use in an animal is disclosed that releases one or more therapeutic agents or drugs. The scaffold uses a drug-releasing microporous annealed particle system that encapsulates drug-loaded nanoparticles into particle building blocks. By modulating nanoparticle hydrophilicity and pre-gel solution viscosity, the particle building blocks were generated with consistent and homogeneous encapsulation of nanoparticles. The scaffold may be used to treat myocardial infarction (MI) using, for example, the drugs forskolin (F) and Repsox (R). The intramyocardial injection of the pre-annealed hydrogel slurry of particles that formed the resultant scaffold improved left ventricular functions, which were further enhanced with increased angiogenesis and reduced fibrosis and inflammatory response.

Abstract: We have discovered a chemical cocktail that selectively induces a robust expansion of myogenic stem cells from readily-obtainable dermal cells and from muscle stromal cells. By differential plating and lineage tracing, we show that Pax7+ cells were the major source for chemical-induced myogenic stem cells (CiMCs). We further performed single-cell RNA sequencing (scRNA-seq) analysis to characterize the transcriptomic profile of CiMCs and demonstrate a specific expansion of myogenic cells from heterogeneous dermal cell population. Upon transplantation into the injured muscle, CiMCs were efficiently engrafted and improved functional muscle regeneration in both adult and aged mice. Furthermore, an in situ therapeutic modality using this cocktail was developed by loading the chemical cocktail into injectable nanoparticles, which enabled a sustained release of the cocktail in injured muscle and a local expansion of resident satellite cells for muscle regeneration in adult and aged mice.

Abstract: The disclosure relates to a method for processing a stereo signal. The method can include obtaining a center channel signal by up-mixing the stereo signal. The method can also include generating a filtered center channel signal by applying one or more peak filters and one or more notch filters to the center channel signal. Furthermore, the method can include generating a binaural signal based on the filtered center channel signal.