Abstract: Disclosed herein is a method for determining whether a subject has or is at risk of developing colorectal cancer with an ex vivo biological sample isolated from the subject. The method comprises: determining the levels of at least two target proteins with the aid of mass spectrometry, in which the at least two target proteins are selected from the group consisting of ADAM10, CD59, and TSPAN9; and assessing whether the subject has or is at risk of developing the colorectal cancer based on the levels of the at least two target proteins. The present method may serve as a potential means for diagnosing and predicting the incidence of colorectal cancer, and the subject in need thereof could receive a suitable therapeutic regimen in time in accordance with the diagnostic results produced by the present method.

Abstract: A thin film transistor includes a bottom gate, a semiconductor layer, a top gate, a first auxiliary conductive pattern, a source, and a drain. The semiconductor layer includes a first semiconductor region, a second semiconductor region, a first heavily doped region, a second heavily doped region, a third heavily doped region, a first lightly doped region, a second lightly doped region, and a third lightly doped region. The first heavily doped region and the second heavily doped region are respectively located on two sides of the first semiconductor region. Two ends of the second semiconductor region are directly connected to the third heavily doped region and the third lightly doped region, respectively. The top gate is electrically connected to the bottom gate. The source and the drain are respectively electrically connected to the third heavily doped region and the second heavily doped region of the semiconductor layer.

Abstract: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.

Abstract: The present invention disclosure also relates to a pharmaceutical composition that ccomprises the compound as an active ingredient.

Abstract: The present invention relates to a hydroxamate compound represented by formula (I), a preparation method therefor, and an application thereof. The present invention also relates to a pharmaceutical composition comprising the compound as an active ingredient and a use of the compound or pharmaceutical composition for treating and/or preventing related diseases mediated by TYK2.

Abstract: A flexible witness service system architecture is provided that comprises one or more cluster sites each having at least two storage/compute nodes; at least one local external device associated with at least one of the one or more cluster sites, the at least one local external device configured to run a local witness service. A central cloud management platform is in communication with the one or more cluster sites, the central cloud management platform being configured to run a cloud witness service. The local witness service and the cloud witness service perform identical arbitration services if a storage/compute node in one of the one or more cluster sites fails or communication between storage/compute nodes in a cluster fails.

Abstract: A method for predicting clinical severity of a neurological disorder includes steps of: a) identifying, according to a magnetic resonance imaging (MRI) image of a brain, brain image regions each of which contains a respective portion of diffusion index values of a diffusion index, which results from image processing performed on the MRI image; b) for one of the brain image regions, calculating a characteristic parameter based on the respective portion of the diffusion index values; and c) calculating a severity score that represents the clinical severity of the neurological disorder of the brain based on the characteristic parameter of the one of the brain image regions via a prediction model associated with the neurological disorder.

Abstract: A folding device is provided. The folding device includes a bearing and fixing mechanism (1) configured to bear and fix a main body portion (21) of a to-be-folded device (2); a folding mechanism (3) located on at least one side of the bearing and fixing mechanism (1), the folding mechanism (3) being rotatably connected to the bearing and fixing mechanism (1) and configured to bear and fix a to-be-folded portion (22) of the to-be-folded device (2); and a driving mechanism (4) connected to the folding mechanism (3), the driving mechanism (4) being configured to drive the folding mechanism (3) to turn relative to the bearing and fixing mechanism (1), so as to fold the to-be-folded portion (22) to a side in a thickness direction of the main body portion (21). The folding device can fold automatically, and manual folding is avoided.

Abstract: The display panel includes: a first substrate and a second substrate disposed opposite to the first substrate, wherein an electrophoresis layer and electrophoresis ions are disposed on the first substrate, the electrophoresis layer is located between the second substrate and the first substrate, the electrophoresis layer is provided with a plurality of electrophoresis tanks arranged in an array, openings of the electrophoresis tanks face the second substrate, and the electrophoresis ions are located in the electrophoresis tanks; and one of the electrophoresis layer and the second substrate is provided with a positioning groove, the other is provided with a positioning block embedded into the positioning groove, and orthographic projections of the positioning groove and the positioning block on the first substrate are at least partially located between orthographic projections of two adjacent electrophoresis tanks on the first substrate. The pressure resistance of the display panel is improved.

Abstract: A flexible witness service system architecture is provided that comprises one or more cluster sites each having at least two storage/compute nodes; at least one local external device associated with at least one of the one or more cluster sites, the at least one local external device configured to run a local witness service. A central cloud management platform is in communication with the one or more cluster sites, the central cloud management platform being configured to run a cloud witness service. The local witness service and the cloud witness service perform identical arbitration services if a storage/compute node in one of the one or more cluster sites fails or communication between storage/compute nodes in a cluster fails.

Abstract: Provided is a device for measuring a gas concentration, including: a preheating module configured to preheat and rectify an input to-be-measured gas to output a first stage gas; a differential pressure conversion module connected to the preheating module, wherein the differential pressure conversion module is configured to allow the first stage gas flowing through to generate a differential pressure change value; and a processing module configured to acquire a volume concentration of the to-be-measured gas according to the differential pressure change value; wherein the differential pressure conversion module comprises a capillary laminar flow unit having a plurality of capillaries, and flow channels of the plurality of capillaries become a main channel of a gas flow, so as to form a laminar flow structure. A method for measuring a gas concentration is further provided, including measuring a concentration of a to-be-measured gas using the above-mentioned device for measuring a gas concentration.

Abstract: The present invention relates to the field of compounds, and in particular to a probucol derivative, a preparation method therefor and use thereof, the probucol derivative having a structure represented by general formula I. The probucol derivative provided in the present invention can be used for the prevention and treatment of vascular diseases including diabetes, cardio-cerebrovascular diseases or complications thereof, and can be effectively used for reducing blood glucose, reducing blood lipid, reducing cholesterol, reducing body weight, reducing triglyceride, anti-inflammatory, and anti-oxidation, etc., having broad prospective applications.

Abstract: A drum washing machine includes a tub; a drum rotatably provided in the tub; an agitator rotatably provided in the drum and having a water spray hole; a driver in transmission connection with the drum via a main shaft, and the main shaft transmitting a torque of the driver to the drum; a planetary gear assembly in transmission connection with the main shaft and the agitator separately, and transmitting the torque of the main shaft to the agitator; a brake linked with the planetary gear assembly, and a water supply device configured to supply water to the agitator.

Abstract: A planetary gear assembly for a drum washing machine and a washing machine are provided. The planetary gear assembly includes a planetary gear component. The planetary gear component includes a planet carrier, a plurality of planetary gears rotatably mounted to the planet carrier separately and configured to be meshed with a main shaft separately, the main shaft being configured to drive a drum to rotate in a drum washing machine; and a planetary gear outer teeth casing fitted over an outer side of the plurality of planetary gears, meshed with the plurality of planetary gears separately, and configured to be in transmission connection with an agitator in the drum.

Abstract: Disclosed herein is a method for diagnosing a neurological disorder based on at least one magnetic resonance imaging (MRI) image. The method includes identifying brain image regions that contain a respective portion of diffusion index values of at least one diffusion index. For each of the brain image regions, a characteristic parameter based on the respective portion of the diffusion index values is calculated. a diagnoses is then made for the brain using one of predetermined categories of the neurological disorder by performing classification on a combination of the characteristic parameters via a classifier.

Abstract: A brake for a drum washing machine and a drum washing machine are disclosed. The brake includes a brake disk, provided on a second shaft; a brake seat, provided with a slideway; a brake pawl, provided to the brake seat, switchable between a state of holding the brake disk and a state of releasing the brake disk; a brake lever, slidably fitted with the slideway between an extending position and a retracting position, and the brake pawl is switched to the tightening state when the brake lever is at the extending position, and the brake pawl is switched to the releasing state when the brake lever is at the retracting position; a brake driver, mounted to the brake seat and in transmission connection with the brake lever, the brake driver driving the brake lever to move between the extending position and the retracting position.

Abstract: The present disclosure relates to an agitator for a drum washing machine and a drum washing machine. The agitator comprises a first agitating subsection and a second agitating subsection, and an agitating rib of the first agitating subsection is provided with water spray holes, the second agitating subsection and the first agitating subsection are separate parts, and the second agitating subsection and the first agitating subsection are mounted and jointly define a water spray channel in communication with the water spray hole.

Abstract: A non-contact transporting apparatus (10) includes: a negative pressure assembly (100) configured to generate a negative pressure airflow within the non-contact transporting apparatus; and an ultrasonic assembly (200) connected to the negative pressure assembly (100). The ultrasonic assembly (200) includes: an ultrasonic transducer (210) configured to convert a high-frequency ultrasonic electrical signal into a high-frequency mechanical vibration, one end of the ultrasonic transducer (210) is connected to the negative pressure assembly (100); an ultrasonic horn (230) configured to amplify the high-frequency mechanical vibration, one end of the ultrasonic horn (230) is connected to one end of the ultrasonic transducer (210) away from the negative pressure assembly (100); and an ultrasonic chuck (250) configured to amplify and convert the high-frequency mechanical vibration, the ultrasonic chuck (250) is connected to one end of the ultrasonic horn (230) away from the ultrasonic transducer (210).

Abstract: A wind power converter device is provided. The wind power converter device includes grid side converters, generator side converters and a DC bus module. Each of the grid side converters includes grid side outputs electrically coupled to a grid and a first and a second DC inputs. Each two of the neighboring grid side converters are connected in series at the second and the first DC inputs. Each of the generator side converters includes generator side inputs electrically coupled to a generator device and a first and a second DC outputs. Each two of the neighboring generator side converters are coupled in series at the second and the first DC outputs. The DC bus module is electrically coupled between the grid side converters and the generator side converters.