Abstract: Disclosed are macroscopic systems of highly concentrated, cross-linked biopolymers. The macroscopic system is created by combining a biopolymer with a cross-linking agent, submerging the resulting product in an aqueous solution which contains additional cross-linking agents, to allow the biopolymer to undergo a second cross-linking process. The resulting macroscopic biopolymer has an increased biopolymer concentration and increased longevity within the body.

Abstract: The present invention discloses a drug delivery system comprising at least one hydrophobic matrix and at least one pharmaceutically active compound. The hydrophobic matrix comprises at least one hydrophobic solid component and at least one hydrophobic liquid component. The pharmaceutically active compound may comprise a biological cell or a biopolymer. The hydrophobic matrix conserves the activity of and protects the functionality of the biological cell or biopolymer in hostile environment, at elevated temperature, cold temperatures or a combination thereof. The present invention also discloses the use of the drug delivery system in a kit for diagnostic or analytical purposes. Additionally, the present invention discloses the use of the drug delivery system to deliver the pharmaceutically active compound to a subject who has or is suspected of having a pathophysiological condition.

Abstract: The present invention discloses methods for manufacturing drug delivery composition comprising at least one pharmaceutically active compound, at least one anti-caking agent and at least one oil. The anti-caking agent and the oil form the matrix when mixed, which then embeds the pharmaceutically active compound.

Abstract: Disclosed are micronized hydrophilic systems of highly concentrated, cross-linked biopolymers. The system is created by combining a biopolymer with a cross-linking agent under mechanical kneading and allowing the biopolymer to undergo a cross-linking process followed by purification, drying and milling. The resulting micronized biopolymer system has an increased biopolymer concentration and increased longevity within the body.

Abstract: Disclosed are biocompatible composite nanoparticles and methods of preparing biocompatible composite nanoparticles. Also disclosed ate composite nanoparticles which are biocompatible, biodegradable and have numerous other advantages, and also examples of preparation of the nanoparticles and applications for intracellular delivery.

Abstract: A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition.

Abstract: Embodiments described herein relate to hydrophilic matrix material and sustained drug-delivery material, and their use in medical and cosmetic applications.

Abstract: A method for manufacturing a drug-delivery composition includes providing at least a pharmaceutically active composition, providing a hydrophobic matrix; and mixing the hydrophobic matrix and the pharmaceutically active composition to form a paste-like or semi-solid drug-delivery composition.

Abstract: A method for manufacturing a drug-delivery composition includes providing at least one pharmaceutically active compound, a dry powder comprising at least a polymer, and an aqueous solution. The dry powder, the pharmaceutically active compound and the aqueous solution are mixed to form a paste-like or semi-solid drug-delivery composition, wherein the aqueous solution is added in an amount of less than or equal to twice the total dry mass of the dry powder.