Patents by Inventor Soo-Yeun Lee
Soo-Yeun Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100344Abstract: Electrostimulating waveforms offering simultaneous and controllable cell-type-specific entrainment are described. The waveforms selectively entrain excitatory versus inhibitory cortical and hippocampal neurons including pyramidal neurons, parvalbumin neurons, and somatostatin neurons. The embodiment provides targeted electrical stimulation (ES) entrainment of excitatory versus inhibitory neurons. For example, the current disclosure provides methods of selectively entraining excitatory neurons with ES frequencies below 30 Hertz (Hz) and in particular embodiments to frequencies below 15 Hz, such as 8 Hz and 4 Hz. The current disclosure also provides methods of selectively entraining inhibitory neurons to ES frequencies of at least 30 Hz and depending on the type of inhibitory neuron, utilizing a frequency that is 30-60 Hz or a frequency that is greater than 100 Hz.Type: ApplicationFiled: December 2, 2021Publication date: March 28, 2024Applicant: Allen InstituteInventors: Constantinos Anastassiou, Soo Yeun Lee
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Patent number: 11801301Abstract: The present disclosure provides variant light-responsive polypeptides, and nucleic acids comprising nucleotide sequences encoding the light-responsive polypeptides. The present disclosure provides methods, devices, and systems for controlling the activity of a cell expressing a variant light-responsive polypeptide of the present disclosure.Type: GrantFiled: September 14, 2016Date of Patent: October 31, 2023Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Karl A. Deisseroth, Andre Berndt, Soo Yeun Lee, Charu Ramakrishnan
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Patent number: 11641267Abstract: The present disclosure discloses a clock and data recovery circuit. The clock and data recovery circuit may include a clock recovery unit configured to output a recovery clock signal by operating a first time-to-digital conversion circuit or a second time-to-digital conversion circuit depending on a phase difference between a clock of an input signal and the recovery clock signal, and a data recovery unit configured to sample data from the input signal and output recovery data.Type: GrantFiled: July 27, 2021Date of Patent: May 2, 2023Assignee: SILICON WORKS CO., LTDInventors: Jong Suk Lee, Young Bok Kim, Chung Hwan Son, Seok Jae Oh, Soo Yeun Lee, Yeh Ju Ka
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Publication number: 20220029779Abstract: The present disclosure discloses a clock and data recovery circuit. The clock and data recovery circuit may include a clock recovery unit configured to output a recovery clock signal by operating a first time-to-digital conversion circuit or a second time-to-digital conversion circuit depending on a phase difference between a clock of an input signal and the recovery clock signal, and a data recovery unit configured to sample data from the input signal and output recovery data.Type: ApplicationFiled: July 27, 2021Publication date: January 27, 2022Applicant: Silicon Works Co., Ltd.Inventors: Jong Suk LEE, Young Bok KIM, Chung Hwan SON, Seok Jae OH, Soo Yeun LEE, Yeh Ju KA
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Patent number: 10864281Abstract: The invention provides novel formulations comprising a stable inclusion complex of tributyrin and a cyclodextrin. In one particular embodiment, the formulation comprises an oven dried inclusion complex of tributyrin and ?-cyclodextrin that is effective in minimizing or preventing the unpleasant taste and odor of tributyrin, thus making it suitable for oral administration and delivery to the digestive tract and intestines. The invention provides compositions of these inclusion complexes and methods of using them that are advantageous as food, medicinal and other products, where the negative sensory properties of tributyrin can be a liability.Type: GrantFiled: September 28, 2018Date of Patent: December 15, 2020Assignee: The Board of Trustees of the University of IllinoisInventors: Joseph D. Donovan, Soo-Yeun Lee, Youngsoo Lee
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Publication number: 20200030446Abstract: Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.Type: ApplicationFiled: October 11, 2019Publication date: January 30, 2020Inventors: Karl A. Deisseroth, Soo Yeun Lee, Charu Ramakrishnan, Andre Berndt
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Patent number: 10478499Abstract: Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.Type: GrantFiled: August 7, 2018Date of Patent: November 19, 2019Assignee: The Board of the Trustees of the Leland Stanford Junior UniversityInventors: Karl A. Deisseroth, Soo Yeun Lee, Charu Ramakrishnan, Andre Berndt
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Publication number: 20190099501Abstract: The invention provides novel formulations comprising a stable inclusion complex of tributyrin and a cyclodextrin. In one particular embodiment, the formulation comprises an oven dried inclusion complex of tributyrin and ?-cyclodextrin that is effective in minimizing or preventing the unpleasant taste and odor of tributyrin, thus making it suitable for oral administration and delivery to the digestive tract and intestines. The invention provides compositions of these inclusion complexes and methods of using them that are advantageous as food, medicinal and other products, where the negative sensory properties of tributyrin can be a liability.Type: ApplicationFiled: September 28, 2018Publication date: April 4, 2019Applicant: The Board of Trustees of the University of llinoisInventors: Joseph D. Donovan, Soo-Yeun Lee, Youngsoo Lee
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Publication number: 20180344851Abstract: Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.Type: ApplicationFiled: August 7, 2018Publication date: December 6, 2018Inventors: Karl A. Deisseroth, Soo Yeun Lee, Charu Ramakrishnan, Andre Berndt
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Patent number: 10098964Abstract: The invention provides novel formulations comprising a stable inclusion complex of tributyrin and a cyclodextrin. In one particular embodiment, the formulation comprises an oven dried inclusion complex of tributyrin and ?-cyclodextrin that is effective in minimizing or preventing the unpleasant taste and odor of tributyrin, thus making it suitable for oral administration and delivery to the digestive tract and intestines. The invention provides compositions of these inclusion complexes and methods of using them that are advantageous as food, medicinal and other products, where the negative sensory properties of tributyrin can be a liability.Type: GrantFiled: March 14, 2016Date of Patent: October 16, 2018Assignee: The Board of Trustees of the University of IllinoisInventors: Joseph D. Donovan, Soo-Yeun Lee, Youngsoo Lee
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Publication number: 20180250402Abstract: The present disclosure provides variant light-responsive polypeptides, and nucleic acids comprising nucleotide sequences encoding the light-responsive polypeptides. The present disclosure provides methods, devices, and systems for controlling the activity of a cell expressing a variant light-responsive polypeptide of the present disclosure.Type: ApplicationFiled: September 14, 2016Publication date: September 6, 2018Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Karl A. Deisseroth, Andre Berndt, Soo Yeun Lee, Charu Ramakrishnan
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Patent number: 10052383Abstract: Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.Type: GrantFiled: March 27, 2015Date of Patent: August 21, 2018Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Karl A. Deisseroth, Soo Yeun Lee, Charu Ramakrishnan, Andre Berndt
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Publication number: 20170283783Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.Type: ApplicationFiled: June 15, 2017Publication date: October 5, 2017Applicant: Incyte CorporationInventors: Vicki S. Kaulback, Reena Khare, Thomas W. Richardson, Joseph P. Marquis, Anita Swarnakar, April J. A. Hafalia, Shanya D. Becha, Narinder K. Chawla-Walia, Mariah R. Baughn, Soo Yeun Lee, Uyen K. Tran, Henry Yue, Danniel B. Nguyen, Michael B. Thorton, Rajagopal Gururajan, Ameena R. Gandhi, Yan Lu, Monique G. Yao, Joana X. Li, Wen Luo, Ernestine A. Lee, Craig H. Ison, Amy D. Wilson, Pei Jin, Ian J. Forsythe
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Publication number: 20170095556Abstract: Aspects of the disclosure include compositions, devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering light-responsive polypeptides, or nucleic acids encoding same, to target cells. The subject compositions and systems include light-activated polypeptides, nucleic acids comprising nucleotide sequences encoding these polypeptides, as well as expression systems that facilitate expression of these polypeptides in target cells. Also provided are methods of using the subject devices and systems to optogenetically manipulate action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or animal subject.Type: ApplicationFiled: March 27, 2015Publication date: April 6, 2017Inventors: Karl A. Deisseroth, Soo Yeun Lee, Charu Ramakrishnan, Andre Berndt
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Publication number: 20160263245Abstract: The invention provides novel formulations comprising a stable inclusion complex of tributyrin and a cyclodextrin. In one particular embodiment, the formulation comprises an oven dried inclusion complex of tributyrin and ?-cyclodextrin that is effective in minimizing or preventing the unpleasant taste and odor of tributyrin, thus making it suitable for oral administration and delivery to the digestive tract and intestines. The invention provides compositions of these inclusion complexes and methods of using them that are advantageous as food, medicinal and other products, where the negative sensory properties of tributyrin can be a liability.Type: ApplicationFiled: March 14, 2016Publication date: September 15, 2016Applicant: The Board of Trustees of the University of IllinoisInventors: Joseph D. Donovan, Soo-Yeun Lee, Youngsoo Lee
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Publication number: 20140356342Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.Type: ApplicationFiled: June 6, 2014Publication date: December 4, 2014Inventors: Vicki S. Kaulback, Reena Khare, Thomas W. Richardson, Joseph P. Marquis, Anita Swarnakar, April J. A. Hafalia, Shanya D. Becha, Narinder K. Chawla-Walia, Mariah R. Baughn, Soo Yeun Lee, Uyen K. Tran, Henry Yue, Danniel B. Nguyen, Michael B. Thorton, Rajagopal Gururajan, Ameena R. Gandhi, Yan Lu, Monique G. Yao, Joana X. Li, Wen Luo, Ernestine A. Lee, Craig H. Ison, Amy D. Wilson, Pei Jin, Ian J. Forsythe
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Patent number: 8779106Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.Type: GrantFiled: July 30, 2012Date of Patent: July 15, 2014Assignee: Incyte CorporationInventors: Vicki S. Elliott, Reena Khare, Thomas W. Richardson, Joseph P. Marquis, Anita Swarnakar, April J. A. Hafalia, Shanya D. Becha, Narinder K. Chawla-Walia, Mariah R. Baughn, Soo Yeun Lee, Uyen K. Tran, Henry Yue, Danniel B. Nguyen, Michael B. Thornton, Rajagopal Gururajan, Ameena R. Gandhi, Yan Lu, Monique G. Yao, Joana X. Li, Wen Luo, Ernestine A. Lee, Ian J. Forsythe, Craig H. Ison, Amy D. Wilson, Pei Jin
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Publication number: 20130058942Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.Type: ApplicationFiled: July 30, 2012Publication date: March 7, 2013Inventors: Vicki S. Elliott, Reena Khare, Thomas W. Richardson, Joseph P. Marquis, Anita Swarnakar, April J.A. Hafalia, Shanya D. Becha, Narinder K. Chawla-Walia, Mariah R. Baughn, Soo Yeun Lee, Uyen K. Tran, Henry Yue, Danniel B. Nguyen, Michael B. Thornton, Rajagopal Gururajan, Ameena R. Gandhi, Yan Lu, Monique G. Yao, Joana X. Li, Wen Luo, Ernestine A. Lee, Ian J. Forsythe, Craig H. Ison, Amy D. Wilson, Pei Jin
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Patent number: 8263378Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.Type: GrantFiled: September 20, 2010Date of Patent: September 11, 2012Assignee: Incyte CorporationInventors: Vicki S. Elliott, Reena Khare, Thomas W. Richardson, Joseph P. Marquis, Anita Swarnakar, April J. A. Hafalia, Shanya D. Becha, Narinder K. Chawla-Walia, Mariah R. Baughn, Soo Yeun Lee, Uyen K. Tran, Henry Yue, Danniel B. Nguyen, Michael B. Thornton, Rajagopal Gururajan, Ameena R. Gandhi, Yan Lu, Monique G. Yao, Joana X. Li, Wen Luo, Ernestine A. Lee, Ian J. Forsythe, Craig H. Ison, Amy D. Wilson, Pei Jin
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Publication number: 20120014937Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) polypeptides and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.Type: ApplicationFiled: September 20, 2010Publication date: January 19, 2012Inventors: Vicki S. Elliott, Reena Khare, Thomas W. Richardson, Joseph P. Marquis, Anita Swarnakar, April J. A. Hafalia, Shanya D. Becha, Narinder K. Chawla-Walia, Mariah R. Baughn, Soo Yeun Lee, Uyen K. Tran, Henry Yue, Danniel B. Nguyen, Michael B. Thornton, Rajagopal Gururajan, Ameena R. Gandhi, Yan Lu, Monique G. Yao, Joana X. Li, Wen Luo, Ernestine A. Lee, Ian J. Forsythe, Craig H. Ison, Amy D. Wilson, Pei Jin