Patents by Inventor Sophia LIU

Sophia LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PAIRED MACROMOLECULE ABUNDANCE AND T-CELL RECEPTOR SEQUENCING WITH HIGH SPATIAL RESOLUTION
    Publication number: 20220177963
    Abstract: The present disclosure relates to compositions and methods for assessing extended length T-cell receptor (TCR) transcript sequences (i.e., TCR transcript sequences that span TCR transcript variable regions) in a spatially-defined manner across a tissue sample, specifically providing for obtaining useful TCR sequences at high spatial resolution while also assessing relative macromolecule abundance (e.g., RNA expression levels) with deep transcriptomic coverage at similarly high-resolution across the tissue sample.
    Type: Application
    Filed: December 6, 2021
    Publication date: June 9, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Fei Chen, Sophia Liu
  • A PSEUDO-RANDOM DNA EDITOR FOR EFFICIENT AND CONTINUOUS NUCLEOTIDE DIVERSIFICATION IN HUMAN CELLS
    Publication number: 20220170006
    Abstract: The present disclosure provides compositions and methods for performance of targeted mutagenesis in higher eukaryotic cells, e.g., mammalian cells, across large stretches of targeted sequence. Compositions and methods that rely upon combination of a bacteriophage polymerase with a nucleic acid-editing deaminase to achieve robust mutagenesis of targeted regions of nucleic acid sequence under control of a phage promoter are specifically provided.
    Type: Application
    Filed: April 3, 2020
    Publication date: June 2, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Fei Chen, Haiqi Chen, Sophia Liu, Samuel Padula, Kettner Griswold
  • DELIVERY OF BIOMOLECULES TO IMMUNE CELLS
    Publication number: 20220064584
    Abstract: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
    Type: Application
    Filed: August 4, 2021
    Publication date: March 3, 2022
    Applicants: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Armon R. Sharei, Shirley Mao, George Hartoularos, Sophia Liu, Megan Heimann, Pamela Basto, Gregory Szeto, Siddharth Jhunjhunwala, Darrell J. Irvine, Robert S. Langer, Klavs F. Jensen, Ulrich H. Von Andrian
  • RNA TICKERTAPE FOR RECORDING TRANSCRIPTIONAL HISTORIES OF CELLS
    Publication number: 20210348217
    Abstract: The invention, in some aspects, includes systems, methods and components of molecular recorders that encode the timing of transcriptional activity into the sequence of RNA, which can then enable a sequencing-based readout of the internal dynamics of cells.
    Type: Application
    Filed: July 16, 2019
    Publication date: November 11, 2021
    Inventors: Samuel Gordon RODRIQUES, Edward BOYDEN, Fei CHEN, Linlin CHEN, Sophia LIU, Ellen ZHONG, Joseph SCHERRER
  • Delivery of biomolecules to immune cells
    Patent number: 11111472
    Abstract: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: September 7, 2021
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Armon R. Sharei, Shirley Mao, George Hartoularos, Sophia Liu, Megan Heimann, Pamela Basto, Gregory Szeto, Siddharth Jhunjhunwala, Darrell Irvine, Robert S. Langer, Klavs F. Jensen, Ulrich H. Von Andrian
  • CHARACTERIZATION OF DOMAIN-SPECIFIC CHARGE VARIANTS OF ANTIBODIES
    Publication number: 20200369720
    Abstract: The present invention provides methods and systems for analyzing the biophysical characteristics of peptides or proteins, such as antibodies, based on enzymatic digestion-assisted imaged capillary electrophoresis (DiCE) to characterize the domain-specific charge variants, preferably within a bispecific antibody. The methods and systems include treating the protein with digestion enzymes to generate components of the protein, reducing or denaturing the components, and separating the components based on their isoelectric points.
    Type: Application
    Filed: May 23, 2020
    Publication date: November 26, 2020
    Inventors: Sophia Liu, Jennifer NGUYEN, Michael ROSCONI, Erica PYLES
  • DELIVERY OF BIOMOLECULES TO IMMUNE CELLS
    Publication number: 20180142198
    Abstract: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
    Type: Application
    Filed: October 30, 2015
    Publication date: May 24, 2018
    Inventors: Armon R. SHAREI, Shirley MAO, George HARTOULAROS, Sophia LIU, Megan HEIMANN, Pamela BASTO, Gregory SZETO, Siddarth JHUNJHUNWALA, Darrell IRVINE, Robert S. LANGER, Klavs F. JENSEN, Ulrich H. VON ANDRIAN