Patents by Inventor Sophia Yang Tsai

Sophia Yang Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays of coup transcription factor interactions in mammalian systems
    Patent number: 5849477
    Abstract: Multiple methods for measuring the COUP-TF system, including: a method to measure the level of COUP-TF by combining antibodies with biological samples and measuring the resultant antibody/COUP-TF complex; the binding of COUP-TF to promoters by combining biological samples with COUP-TF binding oligonucleotides and measuring the resultant complex or gene synthesis; and a method to measure COUP-TF inducable promoters by combining native COUP-TF with nuclear extracts of biological samples and measuring the resultant complexes. The methods when applied to human biological samples can detect diabetes due to COUP-TF or promoter defects. In addition to the methods for measuring the COUP-TF system and associated diseases, there are also the polyclonal and monoclonal antibodies necessary for the methods. These bind to at least one immunoreactive site on COUP-TF. Furthermore, there is a DNA clone containing the genetic coding regions of the COUP-TF protein.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: December 15, 1998
    Assignee: Baylor College of Medicine
    Inventors: Bert William O'Malley, Ming-Jer Tsai, Lee-Ho Wang, Sophia Yang Tsai
  • Method of identifying hormone antagonists and agonists
    Patent number: 5759785
    Abstract: The present invention provides a novel method of determining the antagonist and agonist activity of a compound for steroid hormone receptors. The present invention also provides a method of determining antagonist activity of a compound for a hormone receptor by inducing the conformational change in the receptor. In addition, the present invention provides a novel method of determining the level of agonist activity of a compound for steroid hormone receptors.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: June 2, 1998
    Assignee: Baylor College of Medicine
    Inventors: Ming-Jer Tsai, Bert W. O'Malley, Sophia Yang Tsai, George Francis Allan