Abstract: The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous—as well as peroral administration. The ISVD polypeptides derivatives disclosed herein are thus suitable for treatment of haemophilia A, haemophilia A with inhibitors and acquired haemophilia A by various routes of administration including subcutaneous and peroral administration.

Abstract: A device for steering a wheel assembly in a riding mower has a steering sprocket nonrotatably connected to a rotatable steering column and a transmission chain which is flexible in the plane of the steering sprocket and extends over the steering sprocket and forms, on both sides of the steering sprocket, a rectilinear chain run. Two deflecting wheels arranged on both sides of the steering sprocket are positioned in a deflecting wheel plane turned around the respective chain run lines relative to the plane of the steering sprocket. Each of two transmission chains, which extend over the respective deflecting wheels between the free end of the respective chain runs and the wheel assembly, is, between the steering sprocket and the respective deflecting wheels, coupled by way of a link element to the chain, which is flexible in the plane of the steering sprocket, so as to form a straight line with the chain.

Abstract: The present invention relates to a tightening device for cone belts and the like for use in cone belt transmissions, including at least one preferably driven cone belt pulley which is axially or substantially axially displaceable relative to at least one other, preferably driven cone belt pulley, and a cone belt interconnecting said cone belt pulleys, said tightening device engaging one run of the cone belt by means of a rotary member.