Patents by Inventor Soren Kragh
Soren Kragh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220073638Abstract: Recent advances in the understanding of macrophage biology has revealed that tumor-associated macrophages are very heterogeneous and that several distinct subsets coexist in the tumor microenvironment. These subsets differ not only in terms of expression profile and origin but also in their pro- or anti-tumoral function. Here, the inventors describe a macrophage subset in mouse models of metastatic melanoma that express CD 163. Specific depletion of the CD 163 expressing cells in an anti-PD-1 checkpoint inhibitor resistant melanoma model using cytotoxic lipid nanoparticles conjugated to ?CD163 mAh results in a massive infiltration of CD4+ and activated CD8+ T-cells. Moreover the inventors show that tumors quickly relapsed with combined treatment with anti-PDI antibodies.Type: ApplicationFiled: September 18, 2019Publication date: March 10, 2022Inventors: Toby Lawrence, Søren Kragh Moestrup, Anders Etzerodt
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Publication number: 20200016315Abstract: The present invention relates to removal of hemoglobin from a sample. In particular the present invention relates to a method in which a protein with specificity towards hemoglobin and/or the complex of hemoglobin with haptoglobin is immobilized on a solid support and utilized to remove hemoglobin from a sample comprising hemoglobin, such as a hemolysed sample obtained from a subject.Type: ApplicationFiled: March 23, 2018Publication date: January 16, 2020Inventors: Niels Jonas Heilskov Graversen, Soren Kragh Moestrup, Kirstine Lindhardt Saederup
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Patent number: 9811110Abstract: A system and a method of sampling an event signal using multiple clocking signals each provided in a separate candidate clock domain each of which also receives points in time from a master clock. From each candidate clock domain, clocked by the individual clocking signals, pairs of a received point in time and event signal value are fed to a master clock domain. In the master clock domain, the values of the event signal may be determined over time as a function of master clock time. This may be used for synchronizing operation in the master clock domain of e.g. packet time stamping with an overall time defined by the event signal. Using multiple clocking signals for the sampling, a much more precise sampling of the event signal is facilitated.Type: GrantFiled: October 28, 2015Date of Patent: November 7, 2017Assignee: Napatech A/SInventors: René Krog Josiassen, Søren Kragh
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Patent number: 9724426Abstract: The present invention relates to agents comprising a binding moiety with binding specificity for SRCR domain 1 of the CD163 receptor, for use in medicine. The invention also relates to methods, uses, kits and compositions comprising such agents.Type: GrantFiled: September 29, 2010Date of Patent: August 8, 2017Assignees: AFFINICON APS, AARHUS UNIVERSITY HOSPITALInventors: Niels Jonas Heilskov Graversen, Pia Svendsen, Peter Astrup Christensen, Maciej Bogdan Maniecki, Søren Kragh Moestrup, Holger Jon Møller, Gabriele Anton
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Publication number: 20170119790Abstract: The present invention relates to therapeutic agents for the targeted delivery of an immunosuppressive agent to monocytes and/or monocyte-derived cells comprising a binding moiety with specificity for monocytes and/or monocyte-derived cells and an immunosuppressive agent. In one embodiment, the agent is a glucocorticoid-antibody conjugate. The invention also relates to methods, uses, kits and compositions comprising such agents.Type: ApplicationFiled: December 1, 2016Publication date: May 4, 2017Inventors: Niels Jonas Heilskov Graversen, Pia Svendsen, Peter Astrup Christensen, Soren Kragh Moestrup, Holger Jon Moller, Gabriele Anton
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Publication number: 20160116935Abstract: A system and a method of sampling an event signal using multiple clocking signals each provided in a separate candidate clock domain each of which also receives points in time from a master clock. From each candidate clock domain, clocked by the individual clocking signals, pairs of a received point in time and event signal value are fed to a master clock domain. In the master clock domain, the values of the event signal may be determined over time as a function of master clock time. This may be used for synchronizing operation in the master clock domain of e.g. packet time stamping with an overall time defined by the event signal. Using multiple clocking signals for the sampling, a much more precise sampling of the event signal is facilitated.Type: ApplicationFiled: October 28, 2015Publication date: April 28, 2016Inventors: René Krog Josiassen, Søren Kragh
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Patent number: 9246850Abstract: A method and apparatus adapted to prevent Head-Of-Line blocking by forwarding dummy packets to queues which have not received data for a predetermined period of time. This prevention of HOL may be on an input where data is forwarded to each of a number of FIFOs or an output where data is de-queued from FIFOs. The dummy packets may be provided with a time stamp derived from a recently queued or de-queued packet.Type: GrantFiled: December 27, 2011Date of Patent: January 26, 2016Assignee: Napatech A/SInventor: Søren Kragh
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Patent number: 8708957Abstract: The present invention relates to a medical injection device (1) for use in combination with a medicament filled cartridge (2), the injection device being provided with a spring-assisted injecting mechanism where energy released from the spring moves a plunger (3) of a held cartridge (2). Sensor circuitry is adapted to detect speed related data during injection so at to detect an abnormal speed condition, such as a needle blocking condition, a priming condition or an air purge condition. The invention also relates to a medical injection device comprising sensor circuitry and user communicating means to provide a recommended needle retraction waiting period which is dependent on the speed of injection.Type: GrantFiled: December 31, 2008Date of Patent: April 29, 2014Assignee: Novo Nordisk A/SInventors: Søren Kragh Jespersen, Claus Urup Gjødesen, Andre Larsen
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Publication number: 20130311609Abstract: An apparatus and a method for receiving and forwarding packets, where the packets are received by a number of adapters and fed to a common storage in addresses allocated by a controller. The controller is adapted to forward to the adapters requests and at the same time log which addresses have been allocated to each adapter. As a response to the request, the individual adapter forwards predetermined data to predetermined addresses in the storage so that the controller is able to update the available or the used addresses in the storage.Type: ApplicationFiled: January 11, 2012Publication date: November 21, 2013Applicant: NAPATECH A/SInventors: Søren Kragh, Peter Ekner
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Publication number: 20130279509Abstract: A method and apparatus adapted to prevent Head-Of-Line blocking by forwarding dummy packets to queues which have not received data for a predetermined period of time. This prevention of HOL may be on an input where data is forwarded to each of a number of FIFOs or an output where data is de-queued from FIFOs. The dummy packets may be provided with a time stamp derived from a recently queued or de-queued packet.Type: ApplicationFiled: December 27, 2011Publication date: October 24, 2013Applicant: NAPATECH A/SInventor: Søren Kragh
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Publication number: 20130123685Abstract: Medical injection advice adapted for operating in a dose setting mode and in a dose administration mode, comprising a dosing actuator (124) reversibly actuatable from a first state for operating the device in the dose setting mode to a second state for operating the device in the dose administration mode, a switch (130, 132) adapted to sense positional information associated with the dosing actuator, and a controller coupled to the switch arrangement, wherein electronic mode representation is configured to enter dose setting mode after a time delay following detecting the dosing actuator has moved away from said second state or detecting the dosing actuator has moved into said first state.Type: ApplicationFiled: June 3, 2010Publication date: May 16, 2013Applicant: Novo Nordisk A/SInventors: Soren Kragh Jespersen, Claus Valentin Buschardt, Kim Ejholm Hansen, Bo Kvolsbjerg, Bennie Peder Smiszek Pedersen, Claus Urup Gjødesen, Preben Mikael Nielsen
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Publication number: 20120276193Abstract: The present invention relates to therapeutic agents for the targeted delivery of an immunosuppressive agent to monocytes and/or monocyte-derived cells comprising a binding moiety with specificity for monocytes and/or monocyte-derived cells and an immunosuppressive agent. In one embodiment, the agent is a glucocorticoid-antibody conjugate. The invention also relates to methods, uses, kits and compositions comprising such agents.Type: ApplicationFiled: September 29, 2010Publication date: November 1, 2012Inventors: Niels Jonas Heilskov Graversen, Pia Svendsen, Peter Astrup Christensen, Søren Kragh Moestrup, Holger Jon Møller, Gabriele Anton
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Publication number: 20120258107Abstract: The present invention relates to agents comprising a binding moiety with binding specificity for SRCR domain 1 of the CD163 receptor, for use in medicine. The invention also relates to methods, uses, kits and compositions comprising such agents.Type: ApplicationFiled: September 29, 2010Publication date: October 11, 2012Inventors: Niels Jonas Heilskov Graversen, Pia Svendsen, Peter Astrup Christensen, Maciej Bogdan Maniecki, Søren Kragh Moestrup, Holger Jon Møller, Gabriele Anton
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Publication number: 20110009821Abstract: The present invention relates to a medical injection device (1) for use in combination with a medicament filled cartridge (2), the injection device being provided with a spring-assisted injecting mechanism where energy released from the spring moves a plunger (3) of a held cartridge (2). Sensor circuitry is adapted to detect speed related data during injection so at to detect an abnormal speed condition, such as a needle blocking condition, a priming condition or an air purge condition. The invention also relates to a medical injection device comprising sensor circuitry and user communicating means to provide a recommended needle retraction waiting period which is dependent on the speed of injection.Type: ApplicationFiled: December 31, 2008Publication date: January 13, 2011Inventors: Søren Kragh Jespersen, Claus Urup Gjødesen, Andre Larsen
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Publication number: 20100194537Abstract: The present invention relates to a medicament reservoir adapted to contain a medicament, the reservoir further being adapted to be received by an associated medical delivery device. The reservoir according to the present invention comprises an identification code comprising a plurality of electrode arrays arranged on an exterior surface part of the reservoir. The code comprises a first, a second and a third array of discrete electrodes adapted to electrically couple to transmitter electrodes and receiver electrodes in the reader of the associated medical delivery device. One of the arrays may be provided to obtain a measure of angular alignment between identification code and reader of the medical delivery device.Type: ApplicationFiled: June 9, 2008Publication date: August 5, 2010Applicant: Novo Nordisk A/SInventors: Soren Kragh Nielsen, Bo Erik Berggren, Jeppe Vejgaard-Nielsen
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Patent number: 7597679Abstract: This invention relates to a safety system for an electrically driven medical delivery device for delivering a dose of medication, wherein the safety system is configured for preventing delivery of an erroneous dose of the medicament and comprising detector means for registering mechanical movement, the system comprising at least two detector means (10, 11) for detecting a mechanical parameter and for emitting signals to control circuits (14, 15) configured for controlling the rower supply to driving means (12) for the delivery device. Further, this invention relates to a computer-readable medium comprising a program for controlling a delivery device etc. This allows providing a system that works very quickly, accurately and reliable as to preventing an erroneous dose of medication.Type: GrantFiled: March 26, 2003Date of Patent: October 6, 2009Assignee: Novo Nordisk A/SInventors: Soren Kragh Jespersen, Jens Aage Munk, Jim Radmer, Jens Ulrik Poulsen, Lars Hofmann Christensen, Lars Peter Klitmose
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Publication number: 20070089095Abstract: A system and method for program counter and data tracing in a multi-issue processor is disclosed. Instructions are traced in program sequence order. In one embodiment instructions are traced in graduation order from a reorder buffer. The tracing mechanism of the present invention enables increased visibility into the hardware and software state of the processor core.Type: ApplicationFiled: December 8, 2006Publication date: April 19, 2007Applicant: MIPS TECHNOLOGIES, INC.Inventors: Radhika Thekkath, Franz Treue, Soren Kragh, Vidya Rajagopalan
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Publication number: 20070064760Abstract: An optical device for providing optical amplification comprises a substrate, a radiation sensitive polymer structure provided on the substrate in a shape defined by a number of sidewalls, n, and being doped with an optically active medium, wherein the sidewalls of the structure form a cavity resonator so that an electromagnetic wave upon pumping of the device is emitted laterally. The radiation sensitive polymer may be a photo-definable polymer, such as SU-8. The optical device for providing optical amplification may also comprise a substrate and a photo-definable polymer structure provided and being doped with an optically active medium. The device may have a shape and/or at least one material provided at least along a part of at least one sidewall of the structure so that a beam propagating in the structure will experience total internal reflection when incident on no more than n-1 sidewalls.Type: ApplicationFiled: June 10, 2004Publication date: March 22, 2007Inventor: Soren Kragh
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Patent number: 7159101Abstract: A system and method for program counter and data tracing in a multi-issue processor is disclosed. Instructions are traced in program sequence order. In one embodiment instructions are traced in graduation order from a reorder buffer. The tracing mechanism of the present invention enables increased visibility into the hardware and software state of the processor core.Type: GrantFiled: May 28, 2003Date of Patent: January 2, 2007Assignee: MIPS Technologies, Inc.Inventors: Radhika Thekkath, Franz Treue, Søren Kragh, Vidya Rajagopalan
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Publication number: 20030231116Abstract: This invention relates to a safety system for an electrically driven medical delivery device for delivering a dose of medication, wherein the safety system is configured for preventing delivery of an erroneous dose of the medicament and comprising detector means for registering mechanical movement, the system comprising at least two detector means (10, 11) for detecting a mechanical parameter and for emitting signals to control circuits (14, 15) configured for controlling the power supply to driving means (12) for the delivery device. Further, this invention relates to a computer-readable medium comprising a program for controlling a delivery device etc.Type: ApplicationFiled: March 26, 2003Publication date: December 18, 2003Inventors: Soren Kragh Jespersen, Jens Aage Munk, Jim Radmer, Jens Ulrik Poulsen, Lars Hofmann Christensen, Lars Peter Klitmose