Patents by Inventor Sorin Odisei Manolache

Sorin Odisei Manolache has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8029902
    Abstract: Bactericidal substrates and methods of functionalizing the surface of substrates with quaternary ammonium and quaternary phosphonium groups using non-equilibrium RF plasmas are provided. The methods include the step of treating the surface of a substrate with a plasma to create surface active sites. Some methods include the step of reacting the surface active sites with linker molecules, which are then reacted with quaternary ammonium precursor molecules to provide a substrate surface functionalized with quaternary ammonium precursor groups. Other methods react the surface active sites with polymer precursor molecules under plasma conditions to form a covalently-bound polymer layer having reactive sites. The polymer reactive sites are reacted with quaternary phosphonium precursor molecules to provide a substrate surface functionalized with quaternary phosphonium groups. Also provided are bactericidal substrates having immobilized, covalently-bound quaternary ammonium or quaternary phosphonium groups.
    Type: Grant
    Filed: December 11, 2006
    Date of Patent: October 4, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ferencz S. Denes, Sorin Odisei Manolache, Luis Emilio Cruz-Barba, Alvaro de Jesus Martinez-Gomez
  • Patent number: 7723126
    Abstract: Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epoxy group-containing molecules in situ in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of oxide surfaces, including glass, quartz, silica and metal oxides.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: May 25, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ferencz S. Denes, Sorin Odisei Manolache, Jason M. Helgren, Max G. Lagally, Bradley James Larson
  • Publication number: 20100021654
    Abstract: Methods for producing plasma-treated, functionalized inorganic oxide surfaces are provided. The methods include the steps of subjecting an oxide surface to a plasma to create hydroxyl functionalities on the surface and reacting the hydroxyl functionalities with epoxy group-containing molecules in situ in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of oxide surfaces, including glass, quartz, silica and metal oxides.
    Type: Application
    Filed: March 24, 2004
    Publication date: January 28, 2010
    Inventors: Ferencz S. Denes, Sorin Odisei Manolache, Jason M. Helgren, Max G. Lagally, Bradley James Larson
  • Publication number: 20080138626
    Abstract: Bactericidal substrates and methods of functionalizing the surface of substrates with quaternary ammonium and quaternary phosphonium groups using non-equilibrium RF plasmas are provided. The methods include the step of treating the surface of a substrate with a plasma to create surface active sites. Some methods include the step of reacting the surface active sites with linker molecules, which are then reacted with quaternary ammonium precursor molecules to provide a substrate surface functionalized with quaternary ammonium precursor groups. Other methods react the surface active sites with polymer precursor molecules under plasma conditions to form a covalently-bound polymer layer having reactive sites. The polymer reactive sites are reacted with quaternary phosphonium precursor molecules to provide a substrate surface functionalized with quaternary phosphonium groups. Also provided are bactericidal substrates having immobilized, covalently-bound quaternary ammonium or quaternary phosphonium groups.
    Type: Application
    Filed: December 11, 2006
    Publication date: June 12, 2008
    Inventors: Ferencz S. Denes, Sorin Odisei Manolache, Luis Emilio Cruz-Barba, Alvaro de Jesus Martinez-Gomez
  • Patent number: 7276283
    Abstract: Methods for producing plasma-treated, functionalized carbon-containing surfaces are provided. The methods include the steps of subjecting a carbon-containing substrate to a plasma to create surface active sites on the surface of the substrate and reacting the surface active sites with stable spacer molecules in the absence of plasma. Biomolecules may be immobilized on the resulting functionalized surfaces. The methods may be used to treat a variety of carbon-containing substrates, including polymeric surfaces, diamond-like carbon films and carbon nanotubes and nanoparticles.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: October 2, 2007
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ferencz S. Denes, Sorin Odisei Manolache, Luis Emilio Cruz-Barba, Max G. Lagally, Bradley James Larson