Patents by Inventor Soumya Ray
Soumya Ray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240165239Abstract: Compounds and compositions that have a Protein Recognition Moiety bound to an electrophile for the selective covalent modification of targeted proteins to treat disorders mediated by the targeted protein are described.Type: ApplicationFiled: September 5, 2023Publication date: May 23, 2024Applicant: Hyku Biosciences Inc.Inventors: Guillaume Barbe, Mark George Sauliner, William John Greenlee, Soumya Ray
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Publication number: 20240101539Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.Type: ApplicationFiled: July 11, 2023Publication date: March 28, 2024Applicant: Avilar Therapeutics, Inc.Inventors: Jason Allan Wiles, Srinivasa Karra, Mark George Saulnier, Jesse Jingyang Chen, Kevin Tyler Sprott, Soumya Ray
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Publication number: 20240072809Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.Type: ApplicationFiled: July 11, 2023Publication date: February 29, 2024Applicant: Avilar Therapeutics, Inc.Inventors: Mark George Saulnier, Jesse Jingyang Chen, Srinivasa Karra, Kevin Tyler Sprott, Jason Allan Wiles, Soumya Ray
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Publication number: 20230406854Abstract: Heteroaryl sulfonyl compounds and compositions that have a KRAS Recognition Moiety bound to an electrophile for the selective covalent modification of KRAS, for example a mutant KRAS, to treat KRAS-mediated disorders are described.Type: ApplicationFiled: September 5, 2023Publication date: December 21, 2023Applicant: Umbra Therapeutics, Inc.Inventors: Guillaume Barbe, Mark George Sauliner, William John Greenlee, Soumya Ray
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Publication number: 20230406853Abstract: Heteroaryl sulfonyl compounds and compositions that have a CDK2 Recognition Moiety bound to an electrophile for the selective covalent modification of CDK2 to treat CDK2-mediated disorders are described.Type: ApplicationFiled: September 5, 2023Publication date: December 21, 2023Applicant: Umbra Therapeutics, Inc.Inventors: Guillaume Barbe, Mark George Sauliner, William John Greenlee, Soumya Ray
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Patent number: 11819551Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.Type: GrantFiled: July 29, 2022Date of Patent: November 21, 2023Assignee: Avilar Therapeutics, Inc.Inventors: Mark George Saulnier, Jesse Jingyang Chen, Srinivasa Karra, Kevin Tyler Sprott, Jason Allan Wiles, Soumya Ray
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Publication number: 20230227406Abstract: Provided herein are methods, oligonucleotides, and compositions for modulating levels of at least one target protein in a cell, e.g., by reducing levels of the mRNA of the target protein or inhibiting translation of the mRNA. In some embodiments, the target protein can be the ubiquitin ligase polypeptide, including, but not limited to WWP1, WWP2, and NEDD4. Also provided herein are methods, oligonucleotides, and compositions for treating, ameliorating, delaying or reducing a symptom of a cancer. The present disclosure also relates to compounds, methods and compositions for modulating at least one target protein selected from ubiquitin protein ligase. Also provided herein are compounds, methods, and compositions for treating, ameliorating, delaying or reducing a symptom of a cancer or a viral infection. In particular, the present disclosure is directed to specific small-molecule modulators of HECT domain E3 ligases that are useful in the therapy and diagnosis of cancer and viral infection.Type: ApplicationFiled: June 14, 2021Publication date: July 20, 2023Inventors: Arthur F. Kluge, Soumya Ray, Suresh K. Jain, Detlev Biniszkiewicz, Ekambar R. Kandimalla, Joshua Grady
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Publication number: 20230097256Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.Type: ApplicationFiled: July 29, 2022Publication date: March 30, 2023Applicant: Avilar Therapeutics, Inc.Inventors: Mark George Saulnier, Jesse Jingyang Chen, Srinivasa Karra, Kevin Tyler Sprott, Jason Allan Wiles, Soumya Ray
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Publication number: 20220411388Abstract: The invention provides substituted imidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.Type: ApplicationFiled: September 17, 2020Publication date: December 29, 2022Inventors: Renato T. Skerlj, Elyse Marie Josee Bourque, Soumya Ray, Peter T. Lansbury
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Publication number: 20220380314Abstract: The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.Type: ApplicationFiled: September 17, 2020Publication date: December 1, 2022Inventors: Renato T. Skerlj, Elyse Marie Josee Bourque, Soumya Ray, Rita Scarpelli, Vincenzo Cilibrasi
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Publication number: 20220380319Abstract: The invention provides substituted benzimidazole carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat a medical disorder, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.Type: ApplicationFiled: September 17, 2020Publication date: December 1, 2022Inventors: Renato T. Skerlj, Elyse Marie Josee Bourque, Soumya Ray, Peter T. Lansbury
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Patent number: 10453191Abstract: Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (IVOCT) imagery. One example apparatus includes an image acquisition circuit that accesses a set of IVOCT images, a pre-processing circuit that generates a blood vessel mask based on the IVOCT images, a feature extraction circuit that defines a three dimensional (3D) volume of interest centered on a location in a member of the set of IVOCT images, a classification circuit that generates a classification based on a probability that a voxel represents a type of plaque, and a visualization circuit that provides a visualization, substantially in real time, of a member of the set of IVOCT images and the classification, where the visualization includes a sector classification image, a labeled image, or a 3D visualization. A prognosis or treatment plan may be provided based on the visualization or the classification.Type: GrantFiled: April 19, 2017Date of Patent: October 22, 2019Assignee: Case Western Reserve UniversityInventors: Ronny Y. Shalev, David L. Wilson, Soumya Ray
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Patent number: 10229494Abstract: This disclosure provides systems and methods to automatically classify stent struts as covered or uncovered and to measure the thickness of tissue coverage. As one example, the method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus and detecting struts based on analysis of the image data. Image data corresponding to each of the detected struts is further analyzed automatically to compute an indication of tissue coverage for the stent.Type: GrantFiled: September 22, 2016Date of Patent: March 12, 2019Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Hong Lu, David L. Wilson, Hiram G. Bezerra, Soumya Ray
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Publication number: 20170309018Abstract: Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (IVOCT) imagery. One example apparatus includes an image acquisition circuit that accesses a set of IVOCT images, a pre-processing circuit that generates a blood vessel mask based on the IVOCT images, a feature extraction circuit that defines a three dimensional (3D) volume of interest centered on a location in a member of the set of IVOCT images, a classification circuit that generates a classification based on a probability that a voxel represents a type of plaque, and a visualization circuit that provides a visualization, substantially in real time, of a member of the set of IVOCT images and the classification, where the visualization includes a sector classification image, a labeled image, or a 3D visualization. A prognosis or treatment plan may be provided based on the visualization or the classification.Type: ApplicationFiled: April 19, 2017Publication date: October 26, 2017Inventors: Ronny Y. Shalev, David L. Wilson, Soumya Ray
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Publication number: 20170169566Abstract: This disclosure provides systems and methods to automatically classify stent struts as covered or uncovered and to measure the thickness of tissue coverage. As one example, the method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus and detecting struts based on analysis of the image data. Image data corresponding to each of the detected struts is further analyzed automatically to compute an indication of tissue coverage for the stent.Type: ApplicationFiled: September 22, 2016Publication date: June 15, 2017Inventors: Hong Lu, David L. Wilson, Hiram G. Bezerra, Soumya Ray
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Patent number: 8666983Abstract: Architecture for generating responses to search engine queries. Question/answer pairs are used to provide a predefined question hierarchy to facilitate a search. Informative terms and one or more questions are associated with each question node of the hierarchy. A question posed is mapped into the hierarchy to the most similar question class node, as determined by passages of the question and/or comparing the informative terms of the question and the question/answer node. Weighted informative terms associated with that node are then returned, and can be used by an automatic question answering system to more effectively find an answer to a question.Type: GrantFiled: June 13, 2003Date of Patent: March 4, 2014Assignee: Microsoft CorporationInventors: Eric D. Brill, Soumya Ray
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Publication number: 20090233845Abstract: The invention features contacting (in vitro or in vivo) a receptor-binding ligand with an organic molecule, which can be a small molecule (i.e., an organic molecule that is not a peptide), or a peptide that noncovalently binds to the ligand and either another ligand for the receptor (either a second copy of the first ligand, or a second, different ligand), the receptor itself, or both. Exemplary ligand/receptor pairs include FGF-2/FGF-R1 and EPO/EPO-R. The invention further features pharmaceutical compositions and methods of using such compositions for treating various medical conditions.Type: ApplicationFiled: January 5, 2009Publication date: September 17, 2009Inventors: Soumya Ray, Marc Charette, Seth P. Finklestein
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Publication number: 20060194821Abstract: The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.Type: ApplicationFiled: February 16, 2006Publication date: August 31, 2006Applicant: The Brigham and women's Hospital, Inc.Inventors: Peter Lansbury, Andrew Choi, Soumya Ray, Richard Nowak
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Publication number: 20040254917Abstract: Architecture for generating responses to search engine queries. Question/answer pairs are used to provide a predefined question hierarchy to facilitate a search. Informative terms and one or more questions are associated with each question node of the hierarchy. A question posed is mapped into the hierarchy to the most similar question class node, as determined by passages of the question and/or comparing the informative terms of the question and the question/answer node. Weighted informative terms associated with that node are then returned, and can be used by an automatic question answering system to more effectively find an answer to a question.Type: ApplicationFiled: June 13, 2003Publication date: December 16, 2004Inventors: Eric D. Brill, Soumya Ray