Patents by Inventor Sovouthy Tith

Sovouthy Tith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coumarin derivatives useful as TNF? inhibitors
    Patent number: 7994318
    Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunionflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: August 9, 2011
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Jie Fei Cheng, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Hirotaka Kashiwagi, Yoshiyuki Ono, Yoshiaki Watanabe
  • Coumarin derivatives useful as TNF? inhibitors
    Patent number: 7872142
    Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: January 18, 2011
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Jie Fei Cheng, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Hirotaka Kashiwagi, Yoshiyuki Ono, Yoshiaki Watanabe
  • COUMARIN DERIVATIVES USEFUL AS TNF ALPHA INHIBITORS
    Publication number: 20100197917
    Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunionflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Application
    Filed: March 18, 2010
    Publication date: August 5, 2010
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Jie Fei Cheng, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Hirotaka Kashiwagi, Yoshiyuki Ono, Yoshiaki Watanabe
  • COUMARIN DERIVATIVES USEFUL AS TNF ALPHA INHIBITORS
    Publication number: 20100174076
    Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunionflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Application
    Filed: March 18, 2010
    Publication date: July 8, 2010
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Jie Fei Cheng, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Hirotaka Kashiwagi, Yoshiyuki Ono, Yoshiaki Watanabe
  • Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases
    Patent number: 7723366
    Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R1, R2, R6, and R7 are defined herein.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: May 25, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Thomas Arrhenius, Jie Fei Cheng, Mark E. Wilson, Rossy Serafimov, Masahiro Nishimoto, David Mark Wallace, Sovouthy Tith, Steve Joel Brown, Charles Stanford Harmon, Gary D. Lopaschuk, Jason R. Dyck
  • Coumarin derivatives useful as TNF? inhibitors
    Patent number: 7709664
    Abstract: Novel compounds composition capable of inhibiting TNF? and having anti immunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: May 4, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Jie Fei Cheng, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Hirotaka Kashiwagi, Yoshiyuki Ono, Yoshiaki Watanabe
  • Method for preparing imidazole derivatives
    Patent number: 7385063
    Abstract: The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: June 10, 2008
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Thomas Arrhenius, Mi Chen, Jie Fei Cheng, Yujin Huang, Alex Michael Nadzan, Sovouthy Tith, Masayuki Haramura, David Mark Wallace, Steve Joel Brown, Charles Stanford Harmon, Lin Zhang, Gary D. Lopaschuk, Jason R. Dyck
  • Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators
    Publication number: 20080070869
    Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
    Type: Application
    Filed: September 14, 2007
    Publication date: March 20, 2008
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Thomas Arrhenius, Mi Chen, Jie Fei Cheng, Yujin Huang, Alex Nadzan, Sovouthy Tith, David Wallace, Bin Liu, Masahiro Nishimoto, Gary Lopaschuk, Jason Dyck
  • Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
    Patent number: 7279477
    Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: October 9, 2007
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Thomas Arrhenius, Mi Chen, Jie Fei Cheng, Yujin Huang, Alex Michael Nadzan, Sovouthy Tith, David Mark Wallace, Bin Liu, Masahiro Nishimoto, Gary D. Lopaschuk, Jason R. Dyck
  • Coumarin derivatives useful as TNF? inhibitors
    Patent number: 7026491
    Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: April 11, 2006
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Jie Fei Cheng, Hirotaka Kashiwagi, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Yoshiyuki Ono, Yoshiaki Watanabe
  • Bisphenyl compounds useful as vitamin D3 receptor agonists
    Publication number: 20060025474
    Abstract: The present invention discloses bisphenyl compounds of the formula: wherein R1, R2, R3, R4, R5, R6, X, Y, W are defined herein after. These compounds are useful as pharmaceuticals.
    Type: Application
    Filed: March 8, 2005
    Publication date: February 2, 2006
    Inventors: David Wallace, Thomas Arrhenius, Anna Russell, Dingguo Liu, Amy Xing, Sovouthy Tith, Zheng Hou, Tadakatsu Takahashi, Yoshiyuki Ono, Hirotaka Kashiwagi, Kazuki Shimizu, Hitoshi Ikura
  • Coumarin derivatives useful as TNFalpha inhibitors
    Publication number: 20060020138
    Abstract: Novel compounds composition capable of inhibiting TNF? and having anti immunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Application
    Filed: September 13, 2005
    Publication date: January 26, 2006
    Inventors: Jie Cheng, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Hirotaka Kashiwagi, Yoshiyuki Ono, Yoshiaki Watanabe
  • Coumarin derivatives useful as tnf alpha inhibitors
    Publication number: 20050014705
    Abstract: Novel compounds composition capable of inhibiting TNF? and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.
    Type: Application
    Filed: July 19, 2001
    Publication date: January 20, 2005
    Inventors: Jie Cheng, Thomas Arrhenius, David Wallace, Mi Chen, Sovouthy Tith, Yoshiyuki Ono, Yoshiaki Watanabe
  • Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
    Publication number: 20040087627
    Abstract: The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds.
    Type: Application
    Filed: July 21, 2003
    Publication date: May 6, 2004
    Inventors: Thomas Arrhenius, Mi Chen, Jie Fei Cheng, Yujin Huang, Alex Michael Nadzan, Sovouthy Tith, Masayuki Haramura, David Mark Wallace, Steve Joel Brown, Charles Stanford Harmon, Lin Zhang
  • Methods for treating metabolic diseases using malonyl-coa decarboxylase inhibitors
    Publication number: 20040082564
    Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R1, R2, R6, and R7 are defined herein.
    Type: Application
    Filed: August 19, 2003
    Publication date: April 29, 2004
    Inventors: Thomas Arrhenius, Jie Fei Cheng, Mark E. Wilson, Rossy Serafimov, Masahiro Nishimoto, David Mark Wallace, Sovouthy Tith, Steve Joel Brown, Charles Stanford Harmon
  • Malonyl-coa decarboxylase inhibitors useful as metabolic modulators
    Publication number: 20040063671
    Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
    Type: Application
    Filed: July 21, 2003
    Publication date: April 1, 2004
    Inventors: Thomas Arrhenius, Mi Chen, Jie Fei Cheng, Yujin Huang, Alex Michael Nadzan, Sovouthy Tith, David Mark Wallace, Bin Liu, Masahiro Nishimoto